임주희 교수

BACKGROUND: Despite the expansion of antenatal syphilis screening programs, congenital syphilis (CS) remains a concern. PURPOSE: This study aimed to analyze the manifestation and progress of CS, including treatment and follow-up, based on a nationwide study. METHODS: From the Korean National Health Insurance Service database, a total of 548 infants were examined for CS during their first year of life from 2013 to 2018. Neurosyphilis and complications were investigated using the International Cla

Despite advances in obstetric care, hypoxic ischemic encephalopathy (HIE) remains a significant disease burden. We determined the national trends of HIE prevalence, therapeutic hypothermia (TH) use, mortality, and outcomes from 2012 to 2019. This study included term infants diagnosed with HIE between 2012 and 2019 from the National Health Insurance Service database. The prevalence of HIE was 2.4 per 1000 births without significant change during the period. TH was performed in approximately 6.7%

Spinal cord injury (SCI) causes axonal damage and demyelination, neural cell death, and comprehensive tissue loss, resulting in devastating neurological dysfunction. Neural stem/progenitor cell (NSPCs) transplantation provides therapeutic benefits for neural repair in SCI, and glial cell linederived neurotrophic factor (GDNF) has been uncovered to have capability of stimulating axonal regeneration and remyelination after SCI. In this study, to evaluate whether GDNF would augment therapeutic effe

In this study, starch-lipid complexes were prepared using normal corn starch (NC) and amylosucrase-modified waxy corn starch (ASWC) with myristic acid (C14:0) and palmitic acid (C16:0). The amylosucrase modification elongated branch chains in waxy corn starch leading to an increase of apparent amylose content (29.7%) similar to that of NC (29.0%). The X-ray diffraction of starch-lipid complexes revealed a V-type pattern, a clear indication of complex formation. The ability of the ASWC to complex

We aimed to evaluate risk factors for growth failure in very low birth weight (VLBW) infants at 18-24 months of corrected age (follow-up1, FU1) and at 36 months of age (follow-up2, FU2). In this prospective cohort study, a total of 2,943 VLBW infants from the Korean Neonatal Network between 2013 and 2015 finished follow-up at FU1. Growth failure was defined as a z-score below -1.28. Multiple logistic regression was used to analyze risk factors for growth failure after dividing the infants into s

Purpose : This study aimed to identify the safety of Kangaroo Mother Care (KMC) and to analyze its medical and psychological effects.\n\nMethods : Forty five preterm infants, admitted to Gangnam Severance Hospital NICU from October 2012 to September 2013, were recruited. KMC was performed for 1 hour daily until the discharge by either mother or father. The medical effects in KMC group were compared with historical control group. Psychological effects in KMC group were made a comparison with the

A 14-year-old girl was referred for evaluation of the etiology of Cushing syndrome. During the previous 2 years, she had experienced weight gain, secondary amenorrhea, growth retardation, and back pain. Random serum cortisol level, 24-hour urinary free cortisol excretion, and overnight and low-dose dexamethasone suppression tests suggested Cushing syndrome. Midnight adrenocorticotropic hormone (ACTH) level and high-dose dexamethasone suppression test confirmed Cushing disease. Pituitary magnetic

Abstract Background . Despite the expansion of antenatal syphilis screening programs, congenital syphilis (CS) remains a concern. Purpose. This study aimed to analyze the manifestation and progress of CS, including treatment and follow-up, based on a nationwide study. Methods . From the Korean National Health Insurance Service database, a total of 548 infants were examined for CS during their first year of life from 2013 to 2018. Neurosyphilis and complications were investigated using the Intern

BACKGROUND: Long-term growth data of very low birth weight (VLBW) infants are currently collected in the Korean Neonatal Network (KNN) and National Health Insurance Service (NHIS) database. However, variance in the number of infants, check-up time, and check-up parameters led to decreased credibility of cumulated data. We aimed to compare the data on serial growth outcomes by major morbidities from birth to 5 years in VLBW infants between the KNN and NHIS databases. METHODS: We combined the NHIS

With advancements in neonatal care and nutrition, the postnatal growth of preterm infants has improved; however, it remains an issue. Accurate assessments of growth using a standardized reference are needed to interpret the intrauterine and postnatal growth patterns of preterm infants. Growth in the earlier periods of life can contribute to later outcomes, and the refinement of postnatal growth failure is needed to optimize outcomes. Catchup growth occurs mainly before discharge and until 24 mon

Purpose: Congenital pulmonary airway malformation (CPAM)-a rare developmental anomaly-affects the lower respiratory tract in newborns. By comparing the reliability of diagnostic tools and identifying predictive factors for symptoms, we provide com prehensive clinical data for the proper management of CPAM. Methods: We reviewed the medical records of 66 patients with prenatally diagnosed CPAM delivered at Severance Children's Hospital between January 2005 and July 2017. Results: We enrolled 33 bo

신차 개발 시 프론트 로딩 단계에서 산포요인의 예측 및 제어를 통해 형상뿐만 아니라 승차감 및 핸들링까지 고려하여 성능 통합적인 차량 개발 프로세스를 구축하기 위한 연구가 진행되고 있다. 또한 이 과정에서 확률 통계적 기법을 적용시켜 불확실성 하에서의 시험 결과와 예측 값 간의 오차를 줄이고자 하는 필요성이 증가되고 있다. 본 연구에서는 상용차의 캡 서스펜션과 부시 시스템의 다중반응 문제에 대하여 제어인자와 잡음인자의 불확실성을 고려한 신뢰성기반 최적화 설계를 수행하였다. 실험계획법을 기반으로 주성분분석 기법을 적용함으로써 강건최적설계 값을 도출하였으며, 다중반응 성능지수에 영향이 큰 주요 설계인자를 추려내어 해석비용을 크게 절약하였다. 또한, 결정론적 접근법의 결과값을 기준으로 하여 사용자가 원하는 신뢰도를 만족할 수 있도록 신뢰성기반설계를 수행하였다.