김주현 교수

The pathogenesis of glucocorticoid-induced (GC-induced) bone loss is unclear. For example, osteoblast apoptosis is enhanced by GCs in vivo, but they stimulate bone formation in vitro. This conundrum suggests that an intermediary cell transmits a component of the bone-suppressive effects of GCs to osteoblasts in the intact animal. Bone remodeling is characterized by tethering of the activities of osteoclasts and osteoblasts. Hence, the osteoclast is a potential modulator of the effect of GCs on o

A significant reduction of renal mass results in proteinuria, glomerulosclerosis, and tubulointerstitial injury, culminating in end-stage chronic renal failure (CRF). The accumulation of lipids in the kidney can cause renal disease. Uptake of oxidized lipoproteins via scavenger receptors, reabsorption of filtered protein-bound lipids via the megalin-cubilin complex, and increased glucose load per nephron can promote lipid accumulation in glomerular, tubular, and interstitial cells in CRF. Cellul

A higher radiation dose (> 60 Gy) is associated with increased LRC, PFS, and OS in patients with stage II-III esophageal cancer treated with definitive CRT.

<b>Objective:</b> Mucosal melanoma is an aggressive malignancy with a poor response to conventional therapies. The efficacy of radiotherapy (RT), especially combined with immune checkpoint inhibitors (ICIs), for this rare melanoma subtype remains unknown. We investigated the reciprocal effect of RT and ICI on mucosal melanoma patients. <b>Materials and Methods:</b> We identified 23 patients with 31 tumors who were treated with RT between July 2008 and February 2017. All patients received RT for

BACKGROUND: Accumulation of lipid in the kidney has been shown to promote renal disease. Heavy glomerular proteinuria (nephrotic syndrome) is associated with hyperlipidemia, lipiduria, and progressive kidney disease. Glomerular and tubular epithelial cells in the nephrotic kidney are exposed to large quantities of lipids bound to the filtered proteins whose uptake can raise cellular lipids. Cellular lipid homeostasis is regulated by the influx, synthesis and efflux of lipids. METHODS: We studied

Diffuse intrinsic pontine gliomas (DIPGs) account for 10%-20% of all central nervous system tumors in children and are the leading cause of death in children with brain tumors. Although many clinical trials have been conducted over the past decades, the survival outcome has remained unchanged. Over 90% of children die within 2 years of the diagnosis, and radiotherapy remains the standard treatment to date. To improve the prognosis, hyperfractionated and hypofractionated radiotherapy and/or addit

PURPOSE: To evaluate the outcomes of adjuvant radiotherapy (RT) and to analyze prognostic factors of survival in the International Federation of Gynecology and Obstetrics (FIGO) IB-IIA uterine cervical cancer. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 148 patients with FIGO IB-IIA uterine cervical cancer who underwent surgery followed by adjuvant RT at the Yonsei Cancer Center between June 1997 and December 2011. Adjuvant radiotherapy was delivered to the whole pe

본 연구는 일반계 고등학교 1학년을 대상으로 진로준비행동 촉진 집단상담 프로그램을 실시하여 진로준비행동, 진로의식, 진로결정자기효능감에 미치는 효과를 확인하는데 그 목적을 두었다. 이러한 목적을 위해 서울특별시 소재 Y고등학교 1학년 학생들 중 프로그램 참여의사를 나타낸 24명을 실험집단, 통제집단, 비교집단에 각각 8명씩 무선배정 하였다. 프로그램 운영은 4주 동안 총 8회기, 한 차시마다 50~90분씩 실시하였다. 실험집단에는 진로준비행동촉진 집단상담 프로그램을 실시했으며, 통제 집단에는 아무런 처치를 가하지 않았고, 비교집단에는 또래상담 프로그램을 4주간 총 8회기를 실시하였다. 프로그램의 효과를 검증하기 위하여 실험, 통제, 비교 집단에 진로준비행동, 진로의식, 진로결정자기효능감 척도를 사전, 사후로 실시하였다. 수집된 자료는 공변량분석(ANCOVA)으로 분석하고, 집단 간 사후검정을 위해 Bonferroni의 다중비교 검정을 실시하였다. 분석 결과, 진로준비행동 촉진 집단상

PORT using modern technique markedly reduced local recurrence in retroperitoneal sarcoma patients, with low toxicity. The optimal RT technique, in terms of RT dose and target volume, should be further investigated.

BACKGROUND: The aim of this study was to thoroughly analyze the reproducibility of radiomics feature extraction across three Image Biomarker Standardization Initiative (IBSI)-compliant platforms using a digital phantom for benchmarking. It uncovers high consistency among common features while also pointing out the necessity for standardization in computational algorithms and mathematical definitions due to unique platform-specific features. METHODS: We selected three widely used radiomics platfo

Pelvic RT could be beneficial especially for those with positive resection margins or nodal involvement after radical cystectomy. Radiation fields should be optimized based on the patient-specific risk factors.