이준호 교수
Jun Ho Lee
한양대학교 외과 · 의학
연구실 소개
이준호 교수의 연구실은 위암의 병행성 종양, 조기 위암의 임상적 특성 및 예후 인자에 대한 심층적인 연구를 중심으로 하며, 특히 CCR4, SOX 그룹 F 유전자, 혈장 피브리노겐 수치 등 종양 미세환경과 관련된 생물학적 마커들이 위암 진행과 예후에 미치는 영향을 규명하고자 합니다. 또한, 혈관 생성 및 림프관 형성과 관련된 유전자 기전과 호르몬 영향 등 종양 생물학의 핵심 메커니즘을 밝히는 데 초점을 맞추고 있습니다. 이는 조기 진단 및 개인화된 치료 전략 개발에 기여할 임상의학적 통찰을 제공합니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Synchronous cancers in gastric cancer patients are not infrequent. The physicians should try to find synchronous cancers in gastric cancer patients, especially in the elderly with a differentiated early gastric cancer.
These results suggest that CCR4 and its ligands were associated with increased tumor recurrence and impaired overall survival in patients with gastric cancer.
BACKGROUND: Patients with stage I colorectal cancer (CRC) rarely experience recurrences; therefore, few risk factors for recurrence are known. This study was designed to evaluate oncologic outcomes of patients with stage I CRC and to identify risk factors for recurrence after curative surgery. METHODS: A retrospective cohort of 860 patients from a single institution who underwent curative surgery for stage I CRC between July 1995 and June 2010 was enrolled. Patients who were diagnosed with hered
Pyogenic granuloma (PG) is a type of vascular tumor for which the growth mechanism is poorly understood. Estrogen and progesterone may influence vascular malformations by increasing neovascularization in the lesions. Pregnancy tumor is a term for PG that occurs on the gingival mucosa of pregnant women in response to local irritation or injury. The etiology and pathogenesis of this phenomenon are not fully understood. Hormonal imbalance has been hypothesized to be responsible for the development
BACKGROUND/AIMS: The aim of the present study was to investigate the relationship between the preoperative plasma fibrinogen level and the extent of tumor involvement in gastric cancer patients. METHODOLOGY: Preoperative plasma fibrinogen levels of 354 patients who underwent gastric cancer surgery were quantified using an immunoassay. The relationships between the plasma fibrinogen level and other prognostic variables (tumor size, macroscopic and histological type, depth of tumor invasion, prese
SOX group F genes are important regulators of angiogenesis and lymphangiogenesis. The aim of the present study was to examine the relationships between Sox group F expression and clinicopathological factors in gastric cancer. Three hundred and fifteen gastric cancer tissues and the corresponding normal gastric tissue were obtained from the tumor bank at the National Cancer Center, Korea. SOX group F mRNA levels in these tissues were evaluated by reverse transcriptase polymerase chain reaction (R
OBJECTIVE: There are a few reports on the complications of surgery for epilepsy. We surveyed our data to present complications of epilepsy surgeries from the neurosurgeon's point of view and compare our results with other previous reports. METHODS: A total of 179 surgical procedures for intractable epilepsy (41 diagnostic, 138 therapeutic) were performed in 92 consecutive patients (10 adults, 82 children) during the last 9.2 years (February. 1997-April. 2006). Their medical records and radiologi
ASXL1 might act as a tumor suppressor in CRC. The loss of ASXL1 expression might be associated with lymph node metastasis and lymphatic invasion in CRC.
Background: Aortic dissection (AD) is one of the most catastrophic diseases and is associated with high morbidity and mortality. The aim of this study is to investigate the hospital incidence and mortality rates of thoracic AD in Korea using a nationwide database. Methods: We conducted a nationwide population-based study using the health claims data of the National Health Insurance Service in Korea. From 2005 to 2016, adult patients newly diagnosed with AD were included. All patients were divide
아마씨 분말의 첨가량을 0~8%로 달리하여 파운드케이크를 제조한 후 물리ㆍ화학적 품질, 항산화 활성 및 소비자 기호도를 조사하였다. 케이크의 굽기 손실률은 아마씨 분말의 첨가량이 증가함에 따라 유의적으로 증가하였으며(P<0.05), 수분함량, 부피, 높이 및 경도는 아마씨 분말의 함량이 증가함에 따라 유의적으로 감소하였다(P<0.05). 한편 명도(L<SUP>*</SUP>)와 황색도(b<SUP>*</SUP>)는 황갈색인 아마씨 분말의 첨가량이 증가함에 따라 유의적으로 감소하였으며(P<0.05), 적색도(a<SUP>*</SUP>)는 유의적으로 증가하였다(P<0.05). 항산화 활성을 나타내는 DPPH와 ABTS radical 소거능은 유의적 차이를 나타내며 증가하였으며(P<0.05), 두 지표 사이의 상관관계가 매우 높은 것으로 나타났다. 소비자 기호도 검사 결과 색을 제외한 모든 평가항목에서 아마씨 분말 2% 첨가군이 대조군에 비해 높게 평가되었으며, 아마씨 분말의 첨가량이 증가함에
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