유준현 교수

BACKGROUND AND PURPOSE: A number of investigations support the theory that the elevated plasma homocyst(e)ine is associated with occlusive vascular disease. The aim of this study is to examine whether moderate hyperhomocyst(e)inemia is an independent risk factor for cerebral infarction. In addition, we examined the association between plasma homocyst(e)ine and the severity of cerebral atherosclerosis. METHODS: We conducted a hospital-based case-control study with 140 male controls and 78 male pa

Recent findings on the association of gut microbiota with various diseases, including obesity, prompted us to investigate the possibility of using a certain type of gut bacteria as a safe therapeutic for obesity. Lactobacillus mutants with enhanced capacity in absorption of free fatty acids (FFAs) were isolated to show reduced absorption of FFAs by the administered host, attributing to inhibition of body weight gain and body fat accumulation as well as amelioration of blood profiles. Consequentl

The present article aimed to provide a comprehensive review of current status of end-of-life (EOL) care and sociocultural considerations in Korea, with focus on the EOL communication and use of advance directives (AD) in elderly Koreans. Through literature review, we discuss the current status of EOL care and sociocultural considerations in Korea, and provide a look-ahead. In Korea, patients often receive life-sustaining treatment until the very end of life. Advance care planning is rare, and mo

Although the major biochemical abnormality due to methylenetetrahydrofolate reductase (MTHFR) deficiency is hyperhomocyst(e)inemia, its pathogenicity appears to involve more than homocysteine toxicity. In patients with severe MTHFR deficiency, a metabolite(s) other than hyperhomocyst(e)inemia also appears to be associated with its clinical manifestation in cerebrovascular disease. To elucidate the specific role of the TT genotype of MTHFR in the development of cerebral infarction with and withou

Anemia is a common health problem in older adults and is associated with risk factors for fracture such as low physical function and low bone mass. The aim of this study was to examine the relationship between anemia and fracture risk in older adults. We conducted a retrospective cohort study from 2003 to 2013. The participants were community-dwelling Korean adults aged 65 years and older who participated in the National Health Screening Program (n = 72,131) between 2003 and 2008. Anemia (<12 g/

Folic acid deficiency increases stroke risk. In the present study, we examined whether folic acid deficiency enhances neuronal damage and gliosis via oxidative stress in the gerbil hippocampus after transient forebrain ischemia. Animals were exposed to a folic acid-deficient diet (FAD) for 3 months and then subjected to occlusion of both common carotid arteries for 5 min. Exposure to an FAD increased plasma homocysteine levels by five- to eightfold compared with those of animals fed with a contr

After the adjustment had been made for potential confounders, the total score of occupational stress and six subscales in family medicine residents showed a significant positive correlation with physical symptom scores.

BACKGROUND: Estrogen therapy in early menopausal women decreases the risk of coronary heart disease and parenteral, but not oral, estrogen is reported to reduce blood pressure (BP). Progestogens are typically added to estrogens to prevent unopposed endometrial stimulation. The effects of progestogen on BP have been less well studied to date. This study was conducted to explore the impacts of micronized progesterone (MP4) combined with percutaneous estradiol gel (PEG) on hemodynamics in postmenop

연구배경: 카페인은 의학적으로 인체에 상당한 해가 된다는 일치된 견해가 없고 사회적으로 큰 문제를 일으키지 않아 알코올이나 흡연에 비해 잘 다루어지지 않았으나 이는 많은 사람들이 즐겨 섭취하는 물질이고 최근에 국내 커피 섭취량이 증가하고 있으며, 향후 카페인 함유 식품에 고카페인 표시를 추진할 예정이어서 카페인의 섭취행태와 관련 증상의 조사는 중요하다. 방법: 2003년 10월부터 12월까지 국내 대학생들을 대상으로 체계화된 자기기입식 설문을 한 후 연구대상자 810명에서 사회인구학적 변수, 각각의 카페인 섭취원에 따른 하루 카페인 섭취량의 합을 계산하고 DSM-IV의 물질의존과 카페인의 금단에 대한 연구 진단기준, 카페인중독의 정의를 사용하여 카페인 관련 증상을 평가하였다. 결과: 연구대상자 810명(하루 카페인 섭취량의 평균=120.49 mg) 중 DSM-IV의 물질의존 진단기준에 의한 카페인의 의존성향은 내성 61.1%, 금단 46.3%, 의도보다 많은 양을 섭취 46.0%,

Evidence of the association between anemia and risk of PD (Parkinson's disease) have been accumulating. This study aimed to examine the relationship between anemia and risk of PD in Korean older adults. Korean adults aged 50 years or older who participated in the Korean National Screening Program (n = 12,342,278) between 2009 and 2013 were followed until 2015. Cox proportional hazards regression models were used to calculate the hazard ratio (HR) of PD, and participants were followed for a mean

The present study aimed to elucidate the relationship between cola consumption and bone mineral density (BMD) in Korean adolescents and young adults. We used data from the Korea National Health and Nutrition Examination Survey 2008-2011. A total of 2499 adolescents and young adults aged 12-25 years were included. The study participants were classified as cola drinkers and non-cola drinkers according to 24-h dietary recall data. BMD was measured using dual X-ray absorptiometry. In the male popula

연구배경: 일차진료 의사들은 배우자 학대 피해 발생 시 피해 여성들이 처음 혹은 유일하게 접촉하게 되는 만큼 배우자 학대 피해의 선별과 진단, 추적과 예방에 있어 매우 중요한 위치에 있지만 아직까지 국내에서는 의사들의 배우자 학대 문제에 대한 인식, 태도 그리고 교육 경험 등에 대해 알려진 바는 거의 없어 본 연구를 시행하였다. 방법: 2004년 대한가정의학회 춘계 학술대회에 참석한 가정의학과 전문의 중 191명을 임의 추출하여 미리 준비한 설문지를 배포한 후 이 중 성실히 응답한 125명을 대상으로 분석하였다. 설문은 가정의학회 회원 명부에서 임의 추출한 10명의 전문의를 대상으로 전화를 이용한 사전조사를 실시하여 개발하였으며 설문 대상자의 사회인구학적 특성과 함께 배우자 학대에 관한 태도와 인식, 환자 경험, 개입의 빈도 및 내용, 교육 및 수련의 내용 및 수준, 교육에 대한 요구 및 가장 선호하는 교육 방법, 법적 의무에 대한 인지 여부 등을 포함한 총 5 페이지의 자기 기입식