최준석 교수

The value of skin tests in the diagnosis of adverse drug reactions (ADRs) has been limited. Lack of knowledge as to the nature of drug allergens has contributed to these limitations. Several reports have addressed the roles of metabolites in cutaneous ADRs and skin testing. We evaluated the role of a carbamazepine (CBZ) metabolite on the results obtained from patch tests, using CBZ and its main metabolite 10, 11-epoxide of CBZ (CBZ-epoxide), on 13 patients with CBZ-induced drug eruptions and 39

The purpose of this study was to analyze the incidence and risk factors of possible inferior alveolar nerve (IAN) injury after extraction of the mandibular third molars. A total of 6182 patients were examined for 10,310 mandibular third molar teeth. Panoramic radiography and patients’ medical records were used to analyze age, gender, and impaction pattern of the mandibular third molar. Cone beam computed tomography (CBCT) was used to investigate the detailed pathway of the inferior alveolar nerv

White petrolatum is known for its nonsensitizing and nonirritating properties. Only a few cases of allergic contact dermatitis to white petrolatum have been reported. Although it is a rare event, the finding of contact sensitization to white petrolatum raises the potential problem of its usage of common topical agents or vehicles for patch testing. We herein report a case of allergic contact dermatitis to white petrolatum.

Abstract Background Skeletal muscle glucose utilization is an important component of whole‐body glucose consumption in normal humans. Fluorine‐18‐labelled fluoro‐2‐deoxy‐d‐glucose ( 18 F‐FDG) is a non‐invasive molecular imaging probe for evaluating tissue glucose utilization. It remains unclear whether or not 18 F‐FDG uptake by skeletal muscle has utility as a biomarker for metabolic derangement. We investigated the utility of measurement of muscle 18 F‐FDG positron emission tomography/computed

Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different

본 연구는 OTT 정책 담당 부서인 과학 기술정보통신부와 방송통신위원회, 문화체육관광부의 지원과 규제 방안에 담긴 은유를 분석함으로써 정부 부처의 OTT에 대한 인식 틀과 그 한계를 알아본 후 대안적 시각을 제시한다. 담론 분석 결과, 과학기술정보통신부는 OTT를 통신사업으로 정의하고 망을 사용하는 데이터 송신자로 규정한다. 방송통신위원회는 OTT를 시청각 미디어 서비스로 정의하고 공익적 책임이 있는 방송사로 규정한다. 반면 문화체육관광부는 OTT를 온라인 동영상 서비스로 정의하고 한류 콘텐츠를 수출하는 유통업자로 규정한다. 세 정부 부처는 OTT를 선형적 미디어, 즉, 미디어 데이터와 내용, 문화 창작물을 공간의 한쪽에서 다른 쪽으로 전달하는 수단으로 인식한다. 이는 글로벌 OTT의 국내 확산을 경계한 결과 OTT를 기존 미디어 시스템의 연장으로 파악하여 OTT의 주요 특성인 비선형성과 공간성을 간과하였다. 본 연구는 OTT를 비선형적인 공간적 미디어로 인식을 전환할 때 비로소 국

Multiple myeloma is a monoclonal plasma cell proliferation disorder with various symptoms and signs caused by paraproteinemias. Among these signs, a bleeding tendency is one of the major fatal causes. However, significant severe bleeding is rare in most cases. In this study, we report a case of multiple myeloma in a patient who had a severe recurrent bleeding tendency due to platelet dysfunction caused by paraproteins. After being treated with therapeutic plasma exchange and chemotherapy, the pa

Purpose : Clinical and laboratory findings predict a severe outcome for mucocutaneous lymph node syndrome. This study aimed to define the clinical characteristics of Kawasaki disease (KD) patients with hyponatremia and to determine the factors associated with its development. Methods : Retrospective studies were performed on 114 KD patients who received an initial high-dose intravenous immunoglobulin (IVIG, single 2 g/kg/dose) within 10 days of fever onset from January 2006 to February 2008. The

PURPOSE: The aim of this study was to investigate prophylactic treatment effects in Korean patients with severe hemophilia A. METHODS: A prospective study of 32 severe hemophilia A patients was conducted with the approval of the Institutional Review Board at the Eulji University Hospital. Two patients received primary prophylaxis; whereas, the other 30 patients were divided into 2 groups-secondary prophylaxis (n=15) and on-demand (n=15)-on the basis of their consent for secondary prophylaxis. A

ì„¸ë¡œí† ë‹Œ 증후군은 ì‹ ê²½ê³„ì˜ ì„¸ë¡œí† ë‹Œ 활성도가 지나치게 증가하여 발생하는 것으로 ì •ì‹ ìƒíƒœì˜ 변화, ìžìœ¨ì‹ ê²½ì˜ 과다활동 ê·¸ë¦¬ê³ ì‹ ê²½ê·¼ìœ¡ 이상이라는 세 가지 증후로 나타나는 ë¹„êµì  드문 질환이다. Escitalopram은 selective serotonin reuptake inhibitor로 ì„¸ë¡œí† ë‹Œì„ 활성화시킨다. Amantadine은 인플루엔자 및 파킨슨병 ì¹˜ë£Œì œì´ë‚˜ ì„¸ë¡œí† ë‹Œ 상승 효과가 있다. 또한 amantadine은 소변으로 ë

Background: Human repeated insult patch tests (HRIPTs) are a final method for safety assessment of chemical ingredients. In the representative HRIPTs, the Shelanski and modified Dratze require 200 participants, but the maximization and modified maximization tests require only 25. Objective: To evaluate the safety of three sunscreen ingredients using the Shelanski and maximization methods. Methods: Octylmethoxycmnamate, butylmethoxydibenzoylmethane, and octyltriazone (BASF) were prepared for the