김정범 교수

Recently, decellularized extracellular matrix-based bio-ink (dECM bio-ink) derived from animal organs is attracting attention because of its excellent biocompatibility. However, its poor 3D printability and weak mechanical properties remain a challenge. Here, we developed a new dECM bio-ink with enhanced 3D printability and mechanical properties. dECM micro-particles of about 13.4 μm in size were prepared by decellularizing a porcine liver followed by freeze-milling. The new bio-ink, named as dE

I/sub DDQ/ testing can cover the traditional stuck-at-faults as well as other defects that may affect reliability. One of the most critical issues in I/sub DDQ/ testing is a built-in current sensor (BICS) that can be used to detect abnormal static currents. The most serious problem in the conventional current sensor is performance degradation. The purpose of this work is to present an effective BICS, which has a very small impact on the performance of the circuit under test (CUT). The proposed B

Alzheimer’s disease (AD) is a complex, age-related neurodegenerative disease that is the most common form of dementia. However, the cure for AD has not yet been founded. The accumulation of amyloid beta (Aβ) is considered to be a hallmark of AD. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), also known as beta secretase is the initiating enzyme in the amyloidogenic pathway. Blocking BACE1 could reduce the amount of Aβ, but this would also prohibit the other functions of BACE1 in

Direct conversion from fibroblasts to generate hepatocyte like-cells (iHeps) bypassing the pluripotent state has been described in previous reports as an attractive method acquiring hepatocytes for cell-based therapy. The limited proliferation of iHeps, however, has hampered it uses in cell-based therapy. Since hepatic stem cells (HepSCs) possess self-renewal and bipotency with the capacity to differentiate into both hepatocytes and cholangiocytes, they have therapeutic potential for treating li

This paper proposes a low-power MOS current mode logic circuit with sleep-transistor to reduce the leakage current. The sleep-transistor is used to high-threshold voltage transistor to minimize the leakage current. The 16×16 bit parallel multiplier is designed with the proposed technology. Comparing with the previous MOS current model logic circuit, the circuit achieves the reduction of the power consumption in sleep mode by 1/258. This circuit is designed with Samsung 0.35 ¿m CMOS process. The

The transplantation of pluripotent stem cell (PSC)-derived liver organoids has been studied to solve the current donor shortage. However, the differentiation of unintended cell populations, difficulty in generating multi-lineage organoids, and tumorigenicity of PSC-derived organoids are challenges. However, direct conversion technology has allowed for the generation lineage-restricted induced stem cells from somatic cells bypassing the pluripotent state, thereby eliminating tumorigenic risks. He

Two new circuit designs are proposed to implement the exclusive-OR (XOR) and exclusive-NOR (XNOR) functions on the transistor level. The first circuit uses three transistors and non-complementary signal inputs. The other circuit improves the performance of the prior circuit, hut needs two more transistors. Computer simulations using HSPICE show that the proposed designs realize the expected logic functions and achieve a reasonable performance.

Multi-threshold CMOS (MTCMOS) technology provides the transistors that have low-, normal-, and high-threshold voltage. This paper describes a low-power carry look-ahead adder with MTCMOS technology. While the low-threshold voltage transistors are used to reduce the propagation delay time in the critical path, the high-threshold voltage transistors are used to reduce the power consumption in the shortest path. Comparing with the conventional CMOS circuit, the circuit is achieved to reduce the pow

Due to various social and natural disasters and accidents, physical trauma and mental health damage are increasing. In particular, in addition to direct and physical accident experiences, indirect trauma exposure that is delivered or contacted through family or acquaintances can cause serious stress disorders. In particular, firefighters who perform first aid and disaster prevention activities at various disaster, disaster, and accident sites have a big problem in that they are relatively more p