박정훈 교수

Multiphoton microscopy is the current method of choice for in vivo deep-tissue imaging. The long laser wavelength suffers less scattering, and the 3D-confined excitation permits the use of scattered signal light. However, the imaging depth is still limited because of the complex refractive index distribution of biological tissue, which scrambles the incident light and destroys the optical focus needed for high resolution imaging. Here, we demonstrate a wavefront-shaping scheme that allows clear

Current non-invasive imaging and manipulation of biological systems heavily rely on using light as the probing tool. However, light propagation through highly turbid media such as biological tissue undergo multiple light scattering which results in significant scrambling of light paths and polarization information. Here we demonstrate the full control of polarization dependent light paths through a highly scattering medium by only shaping the incoming wavefront. The resulting polarized state is

Multiple light scattering has been regarded as a barrier in imaging through complex media such as biological tissues. Owing to recent advances in wavefront shaping techniques, optical imaging through intact biological tissues without invasive procedures can now be used for direct experimental studies, presenting promising application opportunities in in vivo imaging and diagnosis. Although most of the recent proof of principle breakthroughs have been achieved in the laboratory setting with speci

We demonstrate controlled wavelength-dependent light focusing through turbid media using wavefront shaping. Due to the dispersion caused by multiple light scattering, light propagation through turbid media can be independently controlled between different wavelengths. Foci with various wavelengths can be generated by applying different optimized wavefronts to a highly scattering layer. Given the linearity of the transmission matrix, multiple foci with different wavelengths can also be simultaneo

Advances in diverse areas such as inspection, imaging, manufacturing, telecommunications, and information processing have been stimulated by novel optical devices. Conventional material ingredients for these devices are typically made of homogeneous refractive or diffractive materials and require sophisticated design and fabrication, which results in practical limitations related to their form and functional figures of merit. To overcome such limitations, recent developments in the application o

Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time, current applications are mostly limited to research settings. This is due to the aberrations and multiple scattering that is induced by the inhomogeneous refractive boundaries that are inherent to biological systems. However, recent developments in adaptive optics and wavefront shaping have shown that high resolution optical imaging is not fundamentally l

Focusing through scattering media is a subject of great interest due to its direct impact in the field of biomedical optics. However, the greatest barrier currently limiting direct applications is the fact that most scattering media that we wish to deliver light through are dynamic. To focus or deliver light through dynamic scattering media, using a digital micromirror device (DMD) has been demonstrated to be a potential solution, as it enables fast modulation speeds. However, since a DMD is a b

Abstract The properties of a semipermeable porous membrane, including pore size, pore density, and thickness, play a crucial role in creating a tissue interface in a microphysiological system (MPS) because it dictates multicellular interactions between different compartments. The small pore-sized membrane has been preferentially used in an MPS for stable cell adhesion and the formation of tissue barriers on the membrane. However, it limited the applicability of the MPS because of the hindered ce

Abstract Nonlinear microscopy provides excellent depth penetration and axial sectioning for 3D imaging, yet widespread adoption is limited by reliance on expensive ultrafast pulsed lasers. This work circumvents such limitations by employing rare‐earth doped upconverting nanoparticles (UCNPs), specifically Yb 3+ /Tm 3+ co‐doped NaYF 4 nanocrystals, which exhibit strong multimodal nonlinear optical responses under continuous‐wave (CW) excitation. These UCNPs emit multiple wavelengths at UV (λ ≈ 45

Abstract A new phase retrieval method for imaging through random media is proposed and demonstrated. Although methods to recover the Fourier amplitude through random distortions are well established, recovery of the Fourier phase has been a more difficult problem and is still a very active and important research area. Here, it is shown that by simply ensemble averaging shift‐corrected images, the Fourier phase of an object obscured by random distortions can be accurately retrieved up to the diff

Imaging through temporally changing aberrations is a common challenge that can be found in many different fields such as astronomy, long-range surveillance, and deep tissue bioimaging. Based on the notions originally developed in speckle interferometry, time-varying aberrations can be used to our advantage to obtain diffraction-limited resolution images through turbulence via bispectrum analysis. However, due to the heavy computational load brought on by the triple correlation and the phase extr

Spatial light modulators (SLMs) have become an indispensable element in modern optics for their versatile performance in many applications. Among various types of SLMs, such as digital micromirror devices (DMD), liquid crystal-based phase-only spatial light modulators (LC-SLMs), and deformable mirrors (DM), LC-SLMs are often the method of choice due to their high efficiency, precise phase modulation, and abundant number of effective pixels. In general, for research grade applications, an additio

Recently, as the information industry and mobile communication technology develop, their study is conducted on the new concept of intelligent structures and maintenance techniques that apply wireless sensor network, USN (Ubiquitous Sensor Network), to social infrastructures such as civil and architectural structures on the basis of the concept of Ubiquitous Computing, which invisibly provides human life with computing, along with mutually cooperating, compromising, and connecting networks to eac