김정환 교수

Many naturally occurring compounds, including beta-phenylethyl isothiocyanate (PEITC) and curcumin, exhibit significant anti-cancer chemopreventive effects. In this study, we investigated the combined effects of PEITC and curcumin in PC-3 human prostate cancer cells and in PC-3 cells that were stably transfected with an NF-kappaB luciferase plasmid (PC-3 C4). We found an additive effect of PEITC and curcumin for the induction of apoptosis. To elucidate the potential mechanisms of this effect, we

Given a signed directed network, how can we learn node representations which fully encode structural information of the network including sign and direction of edges? Node representation learning or network embedding learns a mapping of each node to a vector. The mapping encodes structural information on network, providing low-dimensional dense node features for general machine learning and data mining frameworks. Since many social networks allow trust (friend) and distrust (enemy) relationships

Alternative materials obtained from natural resources have recently garnered considerable attention as an innovative solution to bring unprecedented advances in various energy storage systems. Here, we present a new class of heterolayered nanomat-based hierarchical/asymmetric porous membrane with synergistically coupled chemical activity as a nanocellulose-mediated green material strategy to develop smart battery separator membranes far beyond their current state-of-the-art counterparts. This me

These results demonstrate that NAC protects against renal dysfunction, morphological damage and biochemical changes via the anti-apoptotic pathway in the glycerol-induced rhabdomyolysis model in rats.

The production and application of hydrogen, an environmentally friendly energy source, have been attracting increasing interest of late. Although steam methane reforming (SMR) method is used to produce hydrogen, it is difficult to build a high-fidelity model because the existing equation-oriented theoretical model cannot be used to clearly understand the heat-transfer phenomenon of a complicated reforming reactor. Herein, we developed an artificial neural network (ANN)-based data-driven model us

This study presents an induction heating-based reactor for ammonia decomposition and to achieve a 150 Nm3/h carbon-free green hydrogen production process. The developed metallic monolith reactor acts by increasing the reactor temperature through an electromagnetic induction method using renewable-based electricity. As a result, hydrogen is produced without the generation of air pollutants such as CO2, which are formed via the conventional production pathway. Furthermore, techno-economic analysis

Wet flue gas desulfurization, which is performed in many thermal power plants, has a high desulfurization efficiency and produces desulfurized gypsum as a by-product. Currently, high-grade limestone with a CaCO3 content of 94 wt% or more is used to produce desulfurized gypsum with a purity of 93 wt% or more. However, high-grade limestone resources are depleting, so new substitutes to this are required. The objective of this work is to optimize the wet flue gas desulfurization system using recycl

Hepatitis B virus (HBV) causes both acute and chronic infection of the human liver and is associated with the development of liver cirrhosis and hepatocellular carcinoma. UBP43 (USP18) is known as an ISG15-deconjugating enzyme and an inhibitor of type I IFN signaling independent of its enzyme activity. In this study, we examined the role of these two previously identified functions of UBP43 in the innate immune response to HBV viral infection. As an in vivo HBV replication model system, a replic

Strong near-infrared (NIR) electroluminescent emission at wavelengths used in telecommunication optical fibers was produced from rare-earth-doped GaN semiconductors in thin-metal-film/semiconductor/insulator/metal structures (see Figure). Strong near-infrared emission at wavelengths of 800 nm, 1082 nm, and 1550 nm has been demonstrated at room temperature with the trivalent thulium-, neodymium-, or erbium-doped GaN devices, respectively.