강주완 교수
Juwon Kang
연세대학교 이비인후과 · 의학
연구실 소개
강주완 교수의 연구실은 약물 개발 및 생물학적 암 치료 메커니즘을 중심으로, 천연물 성분이 암세포에 미치는 Apoptosis 유도 작용을 규명하는 데 초점을 맞추고 있습니다. 동시에 나노플라스모닉스를 활용한 광학 장치의 설계 및 전자기적 특성 분석을 통해 나노광학 회로 기반의 신소재 응용을 연구하고 있습니다. 또한 환경 오염물질과 건강 간의 상관관계, 특히 아토피 피부염과 실내 대기 중 중금속 농도의 연관성을 분석하는 환경의학 연구도 진행 중입니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15EGb 761, extracted from Ginkgo biloba leaves, has been proven to induce caspase-3-dependent apoptosis in oral cavity cancer cells. Since EGb 761 is a composition of various components, it is important to identify which components are responsible for its anticancer effects to reduce the total dosage and to avoid toxicity. Therefore, the study aimed to determine the effective compounds of EGb 761 that induce apoptosis in oral cavity cancer cells and to identify whether caspase-3 was involved in ap
We present a local capacitor model that enables a simple yet quantitatively accurate description of lightning rod effect in nanoplasmonics. A notion of lambda-zone capacitance is proposed and applied to predict the strongly induced electric field by a light source near nanoscale metal edges such as metal tip or metal gap. The enhancement factor, calculated from the local capacitor model, shows excellent agreement with more rigorous results. The lambda-zone capacitor allows a blockwise treatment
OBJECTIVES: To investigate the association between self-reported sleep duration and serum vitamin D level in elderly Korean adults. DESIGN: Cross-sectional data analysis. SETTING: Korean National Health and Nutrition Examination Survey 2010. PARTICIPANTS: Noninstitutionalized adults aged 60 to 80 (N = 1,614). MEASUREMENTS: The confounding variables were serum 25-hydroxy vitamin D level, age, sex, body mass index, smoking history, alcohol consumption, and self-reported daily sun exposure and slee
-activated chloride channel, and it is closely related to fluid secretion in airway mucosal epithelia. We investigated whether histamine directly induces fluid secretion from epithelial cells or submucosal glands (SMG) and mechanisms related, therewith, in allergic airway diseases. In pig airway tissues from the nose or trachea, histamine was a potent secretagogue that directly induced strong responses. However, gland secretion from human nasal tissue was not induced by histamine, even in allerg
This study was aimed at exploring the reclamation of sewage treatment plant effluent water (SEW) as an alternative water resource. For the oxidation of SEW, an ozone-UV system, based on the results of the combined ozone/UV process performed in our previous study, was set up under practical conditions, including a series type, continuous mode, semi-pilot scale operation (1.5 m3/d). As a result, the serial contact of the ozone and UV reactors showed lower CODCr and TOC removal efficiencies. Howeve
Background: A correlation between the harmful effects of air pollutants and atopic dermatitis has been reported. There are few studies on the correlation between the concentration of heavy metals in the indoor atmosphere and symptoms of atopic dermatitis. Methods: Twenty-two homes of children showing atopic dermatitis symptoms were enrolled, and eighteen homes with similarly aged children without symptoms or a history of atopic dermatitis participated as a control group. We measured the concentr
The purposes of this study were to evaluate the efficiency of acetone removal by electron beam irradiation in groundwater and the effect of various conditions. According to the results, the removal kinetics of acetone were pseudo first-order, and the removal efficiencies were expressed to the (%) removal and G-values. By adding sulfite, it was confirmed that acetone was mainly degraded by the reaction with the hydrated electrons. The presence of nitrate caused the removal of acetone to decrease.
A 76-year-old woman presented with a several-year history of slow-growing masses on both lateral aspects of her tongue. She reported having no pain, dysphagia, or dysarthria. She also reported no intake of alcohol, and she was not obese (body-mass index [the weight in kilograms divided by the square of the height in meters], 23.4). The physical examination showed diffusely yellow globular masses on both lateral borders of the tongue (Panels A and B). There were no abnormal findings on the neck a
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