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There were no significant differences between the AUROCs for Cirrus GCIPL, RNFL, and ONH parameters, indicating that these maps have similar diagnostic potentials for glaucoma. The minimum GCIPL showed better glaucoma diagnostic performance than the other parameters at comparable specificities. However, other GCIPL parameters showed performances comparable to those of the RNFL parameters.

In cases of high myopia, the glaucoma detection ability of macular GCIPL thickness was high and comparable with that of peripapillary RNFL thickness.

There were no significant differences between the AUROCs for Cirrus and Stratus OCT, indicating that the two devices have similar diagnostic potentials in preperimetric glaucoma. After comparison with their normative databases, Cirrus OCT had generally higher sensitivities; however, this was largely at the cost of lower specificities than Stratus OCT.

PURPOSE: To investigate whether heat shock protein (Hsp) 72 is induced in retinal ganglion cells (RGCs) in experimental rat glaucoma and whether the induction of Hsp72 by heat stress or zinc (Zn(2+)) administration can increase survival of RGCs in the model. METHODS: Intraocular pressure (IOP) was elevated unilaterally in Wistar rats with argon laser irradiation of the trabecular meshwork 5 days after intracameral injection of india ink. Immunohistochemical staining for Hsp72 was performed. The

BACKGROUND/AIMS: This study aimed to investigate treatment patterns and medication adherence of glaucoma. It also identified key factors associated with non-adherence. METHODS: It was a cross-sectional, observational study. Patients who use eye-drops for ≤2 years were recruited at 15 eye clinics from March to November 2013. Data were collected through self-administered questionnaires and medical chart review. Medication adherence was evaluated using patients' self-report on pill count and define

The macular area is important to the detection of glaucomatous retinal ganglion cell (RGC) damage. Macular thickness complementary to peripapillary retinal nerve fibre layer (RNFL) thickness can well reflect glaucomatous damage, given that the macula contains more than 50% of the RGCs in a multilayered pattern and larger RGC bodies compared with their axons. Thus, macular ganglion cell thickness parameters recently have been considered to be an effective glaucoma-diagnostic tool comparable to RN

PRéCIS:: A spectral-domain optical coherence tomography (SD-OCT) based deep learning system detected glaucomatous structural change with high sensitivity and specificity. It outperformed the clinical diagnostic parameters in discriminating glaucomatous eyes from healthy eyes. PURPOSE: The purpose of this study was to assess the performance of a deep learning classifier for the detection of glaucomatous change based on SD-OCT. METHODS: Three hundred fifty image sets of ganglion cell-inner plexifo

PURPOSE: To investigate the long-term reproducibility of macular ganglion cell analysis in clinically stable glaucoma patients using spectral-domain optical coherence tomography (SD-OCT). METHODS: One hundred nine eyes of 109 clinically stable open-angle glaucoma patients with a localized retinal nerve fiber layer (RNFL) defect and a corresponding macular ganglion cell-inner plexiform layer (GCIPL) defect were included in this retrospective, longitudinal study. Clinical stability was defined as

PURPOSE: We evaluated the glaucoma detection ability of macular ganglion cell-inner plexiform layer (GCIPL) thickness measured by spectral-domain optical coherence tomography (SD-OCT) and compared it to peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters in myopic preperimetric glaucoma (PPG). METHODS: We analyzed 353 eyes, including 67 nonmyopic preperimetric glaucomatous eyes, 182 myopic healthy eyes, and 104 myopic preperimetric glaucomatous eyes. My