오기원 교수

OBJECTIVE: Body weight is a significant predictor of bone mass. Hormonal factors such as sex hormones, insulin, leptin and adiponectin are thought to play a role in the mechanisms controlling the association of body weight and fat mass with bone mass. However, contradictory results have been reported for the association between serum adipocytokines and bone mineral density (BMD). We therefore examined whether the serum adipocytokine and ghrelin levels, markers of fat metabolism, are associated w

OBJECTIVE: Osteoporosis is a growing health problem in males as well as in females. Sex hormones and insulin-like growth factor-I (IGF-I) have been shown to be the major determinants in male bone metabolism. Osteoprotegerin (OPG) is a recently identified cytokine that acts as a decoy receptor for the receptor activator of NF-kappaB ligand (RANKL). OPG and RANKL have been shown to be important regulators of osteoclastogenesis. However, the relationship between the OPG-RANKL system and male bone s

Serum ferritin, but not iron level, was a significant predictor of hypertension in middle-aged Korean men. Fatty liver disease and insulin resistance may be mediators of this high ferritin-hypertension association.

OBJECTIVE: Osteoprotegerin (OPG) is a recently identified cytokine that acts as a decoy receptor for the RANK ligand. Moreover, OPG has been shown to be an important inhibitor of osteoclastogenesis in animal models. However, the relationship between circulating OPG levels and female bone status in human populations is unclear. In this study we undertook to investigate the relationship between circulating OPG levels and bone mineral metabolism in healthy women. PATIENTS AND MEASUREMENTS: Our subj

OBJECTIVE: The role of adiponectin in bone metabolism has been recently reported in in vitro and in vivo studies. There has been no report on the association of adiponectin gene polymorphism and bone mineral density (BMD). Therefore, we investigated whether two single nucleotide polymorphisms (SNPs), T45G and G276T, in the adiponectin gene were related to BMD in Koreans. We also report on the identification of adiponectin and its receptors 1 and 2 in human osteoblast-like cell lines. PATIENTS AN

OBJECTIVE: Osteoprotegerin (OPG) is a recently identified cytokine that acts as a decoy receptor for the receptor activator of the NF-kappaB ligand (RANKL). OPG has been shown to be an important inhibitor of osteoclastogenesis and arterial calcification in animal models. OPG has been proposed as a link molecule between osteoporosis and arterial calcification, but the relationship between the OPG gene and the cardiovascular system in human populations is unclear. Thus, the aim of this study was t

Increased life expectancy and increased obesity have contributed to an increasing incidence of osteoporosis and diabetes mellitus. Recent meta-analyses and cohort studies confirm that diabetes is associated with a higher risk of fracture. Patients with type 2 diabetes exhibit increased fracture risks despite a higher bone mass, which are mainly attributable to non-skeletal risk factors. Patients with type 1 diabetes may have impaired bone formation because of absence of the anabolic effects of i

Increased life expectancy and increased obesity have contributed to an increasing incidence of osteoporosis and diabetes mellitus. Recent meta-analyses and cohort studies confirm that diabetes is associated with a higher risk of fracture. Patients with type 2 diabetes exhibit increased fracture risks despite a higher bone mass, which are mainly attributable to non-skeletal risk factors. Patients with type 1 diabetes may have impaired bone formation because of absence of the anabolic effects of i

Recent The Korean Society of Bone Metabolism guidelines recommended bone mineral density (BMD) in postmenopausal women; in women during the menopausal transition with clinical risk factors for osteoporosis; in premenopausal women with amenorrhea longer than 6 months; in men aged 70 and older; in men under age 70 with clinical risk factors for osteoporosis; in adults with a fragility fracture; in adults with diseases or taking medications associated with secondary osteoporosis; in anyone being co

474 Cystatin C는 122 아미노산과 13 kD의 작은 단백질로서 시스테인 단백분해효소의 억제제이다. Cystatin C는 세포 외 단백질분해 제어, 면역계 조절, 항균 및 항바이러스 활성, 뇌손상에 대한 신체 반응 등 다수의 생물학적 기능을 가지 고 있다 . Cystatin C는 일정한 속도로 생산되며, 연령, 성 별, 근육량이 Cystatin C의 생산에 영향을 미치지 않고, 작 은 크기와 염기성으로 인하여 사구체에서 자유롭게 여과되 며, 근위부 세뇨관에서 대부분 재흡수되고, 신세뇨관 분비와 혈액으로의 재흡수가 거의 없으며, 분석에 있어 간섭현상이 매우 적어, 사구체 여과율의 내인성 표지자로서 혈청 크레 아티닌과 비교하여 많은 장점을 가지고 있다 . 실제로 대부 분의 신기능 관련 표지자의 비교 논문들에서는 혈청 Cystatin C가 혈청 크레아티닌 보다 사구체 여과율과 신기 능에 대한 더욱 우월한 표지자로 일관되게 보고되고 있으며, 이에 대한 대규모의 메타분석에서도 혈청

Background: Osteoprotegerin (OPG) is a recently identified cytokine, which acts as a decoy receptor for the receptor activator of the NF-B ligand (RANKL), and has also been shown to be an important inhibitor of osteoclastogenesis in animal models. However, the relationship between OPG gene polymorphism and female bone stati in human populations is unclear. In this study, the relationship between OPG gene polymorphisms and bone mineral metabolism in healthy Korean women was investigated.