주계일 교수

Melanoma is one of the most threatening cancers due to its metastatic capacity and its incidence is recently increasing due to ozone depletion and excessive exposure to ultraviolet. Adjuvant therapy after primary surgical resection is commonly used to prevent tumor recurrence. However, its clinical outcome is not often satisfactory, mainly due to insufficient local accumulation and the systemic toxicity of antitumor drugs. Herein, we reported a self-biodegradable tissue adhesive microneedle (MN)

Among many treatment options to prevent cancer progression, cancer immunotherapy has become a powerful clinical strategy due to its favorable clinical outcomes. The number of clinical trials in immune checkpoint blockade (ICB) therapy and chimeric antigen receptor (CAR)-T cell therapy has been remarkably increasing in recent years. However, the currently available options for these treatments pose significant challenges related to immune-related adverse effects and limited therapeutic efficacy.

Biodegradable materials have been received great attention as bone graft substitutes for bone regeneration and tissue engineering. However, their low mechanical property remains a major challenge for the use in loadbearing applications. Here, we developed mechanically reinforced composite scaffold containing adhesive levan as a binder for sintered hydroxyapatite (sHAp) and then examined the mechanical and thermal properties of the composite scaffold. We found that sHAp-levan composite scaffold e