이경아 교수

Delta neutrophil index (DN) is the immature granulocyte fraction provided by a blood cell analyzer (ADVIA 2120; Siemens Healthcare Diagnostics, Deerfield, Ill), which is determined by subtracting the fraction of mature polymorphonuclear leukocytes from the sum of myeloperoxidase-reactive cells. The purpose of this study was to define the role of DN in differential diagnosis and prognosis prediction of patients with sepsis. Hospital records of 273 patients were retrospectively collected: 47 with

본 연구에서는 대학생들의 학교적응수준을 파악하는데 활용될 수 있는 간편 대학생활적응척도를 제작하기 위해 기존의 대학생활 적응 측정도구와 연구결과를 토대로 상담전문가 및 학생 면담을 거쳐 학생들의 적응상의 문제를 잘 반영하는 문항을 선정하였다. 선정된 문항은 예비연구에서 전문가의 평가 및 탐색적 요인분석을 거쳐 적응수준과 적응자원 차원으로 구분되었다. 또한 고위험군 대학생의 위기 문제 정도를 측정하기 위해 임상 경험 5년 이상인 상담 전문가 5인의 합의를 거쳐 위기문항이 포함되었다. 본연구에서는 구성된 검사의 신뢰도와 타당도를 알아보기 위해 먼저 각 하위척도별로 내적합치도를 살펴보고, 확인적 요인분석을 통해 구성개념 타당도를 검증하였다. 또한 대학생활적응척도의 하위요인들과 U&I 학습유형검사, 정서지능, Brief Symptom Inventory(BSI) 및 Focused Group Interview를 통해 추출된 대학생활적응관련 문항들과의 상관분석을 통해 준거관련 타당도를 알아보았다

MSAF was found in only 2.8% (28/1008) of women who delivered before the onset of labor, but in 23.1% (778/3368) of women who delivered after the onset of labor. The longer the duration of labor, the higher the risk of MSAF in term singleton gestation.

BACKGROUND: The exosomal nucleic acid (exoNA) from the plasma and pleural fluid can potentially provide means to identify genomic changes in non-small cell lung cancer (NSCLC) patients who develop resistance to targeted epidermal growth factor receptor (EGFR) inhibitor therapy. METHODS: We compared the performance of the following tools to detect EGFR mutations in 54 plasma samples and 13 pleural fluid using cfDNA, combined TNA (exoTNA + cfTNA), or total cellular DNA: droplet digital PCR (ddPCR)

BACKGROUND: EGFR mutation is an emerging biomarker for treatment selection in non-small-cell lung cancer (NSCLC) patients. However, optimal mutation detection is hindered by complications associated with the biopsy procedure, tumor heterogeneity and limited sensitivity of test methodology. In this study, we evaluated the diagnostic utility of real-time PCR using malignant pleural effusion samples. METHODS: A total of 77 pleural fluid samples from 77 NSCLC patients were tested using the cobas EGF

Patients with reduced ability to metabolize environmental carcinogens or toxins may be at risk of developing aplastic anemia. Glutathione S-transferase (GST) has been implicated in detoxifying mutagenic electrophilic compounds. This study asked whether the homozygous gene deletions of GSTM1 and GSTT1 affect the likelihood of developing aplastic anemia. The incidence of GSTM1 and GSTT1 gene deletions was significantly higher for aplastic anemia patients (odds ratio [OR]: 3.1, P =.01 and OR: 3.1,

Anti-epidermal growth factor receptor (EGFR) therapy has been tried in triple negative breast cancer (TNBC) patients without evaluation of molecular and clinical predictors in several randomized clinical studies. Only fewer than 20% of metastatic TNBCs showed response to anti-EGFR therapy. In order to increase the overall response rate, first step would be to classify TNBC into good or poor responders according to oncogenic mutation profiles. This study provides the molecular characteristics of

Abstract Background Exosomal nucleic acid (exoNA) is a feasible target to improve the sensitivity of EGFR mutation testing in non-small cell lung cancer patients with limited cell-free DNA (cfDNA) mutant copies. However, the type and size of target exoNA related to the sensitivity of EGFR mutation testing has not been explored extensively. Methods The type and size of target exoNA related to the sensitivity of EGFR mutation testing was evaluated using ddPCR. A total of 47 plasma samples was test

OBJECTIVE: The aim of this study was to determine whether polymorphisms in the lymphotoxin (LTA)-tumor necrosis factor (TNF) region are associated with the risk of migraine. BACKGROUND: Previous studies concerning the role of TNFalpha in migraine have provided conflicting results. It has been reported that LTA could be a susceptibility gene in migraine. It is possible that the TNFalpha polymorphism associated with migraine is in linkage disequilibrium with other functional polymorphisms that inf

무청별 무청의 성분분석과 반응표면 분석법을 이용하여 건조조건에 따른 무청 고유의 색도, 칼슘, 철분, 비타민 등의 성분을 조사하였다. 일반성분의 경우 품종이 다른 미농단백무(RL5)를 제외하고는 품종 간에 회분, 단백질, 지방, 칼슘 및 철분함량에 유의적인 차이가 없었고, 건물량으로 환산한 비타민류, 클로로필 함량, 색도에는 품종 간 유의적인 차이가 있었다. 한편 중심합성 실험계획에 따라 건조한 미농단백무 무청의 품질특성을 조사한 결과 수분함량, 클로로필 함량 및 색도차이를 나타내는 ΔE 값은 건조온도와 시간에 따라 유의적인 차이가 있었고, 칼슘, 철분함량은 각각 31.41~35.80 ㎎, 0.21~0.29 ㎎으로 시료 간 유의성이 없었다. 무청의 건조조건을 독립변수로 하고, 시료 간 유의적인 차이를 보였던 종속변수인 수분, 클로로필 및 색도 값의 상관관계를 나타내는 R²값이 0.97 이상으로 높았다. 또 회귀분석한 모델식중 반응표면 분석법으로 도시한 결과 총 클로로필 함량은 독립변

BACKGROUND: Myocardial fibrosis is an important prognostic factor in hypertrophic cardiomyopathy (HCM). However, the contribution from a wide spectrum of genetic mutations has not been well defined. We sought to investigate effect of sarcomere and mitochondria-related mutations on myocardial fibrosis in HCM. METHODS: In 133 HCM patients, comprehensive genetic analysis was performed in 82 nuclear DNA (33 sarcomere-associated genes, 5 phenocopy genes, and 44 nuclear genes linked to mitochondrial c