정경준 교수

Purpose : To detect microdeletion of 15q11-13 region, high resolution cytogenetic analysis or FISH with probe at Prader-Willi syndrome region can be used. We tried to evaluate whether FISH with SNRPN is a more effective method than G-banding microscope in the diagnosis of Prader-Willi syndrome. Methods : Peripheral blood sampling was done on five patients who we suspected of Prader-Willi syndrome clinically and lymphocytes from peripheral blood sampling were cultured. G-banding microscope was us

Exposure to fine particle (PM2.5, particles with an aerodynamic diameter≤2.5 μm) has been demonstrated to be associated with adverse health effects, including local and systemic inflammation in the body, lung function decline and increases in mortality and morbidity of cardiopulmonary diseases. Fractional exhaled nitrogen oxide (FeNO) is a non-invasive surrogate marker of airway inflammation and chronic airway inflammation is a key characteristic in the pathogenesis of asthma. Existing fine part

Purpose : Growth hormone(GH) is a powerful inhibitor of lipoprotein lipase and is known to decrease fat cell mass. The lipolytic effect has more pronounced influence on visceral fat than subcutaneous fat. The effects of GH therapy on GH receptor in fat tissue are not clear. We in- vestigated the changes in fat tissue and GH receptor mRNA in adipose tissue with GH therapy. Methods : Eight children with growth hormone deficiency(GHD) and 9 children with Prader-Willi syndrome(PWS) were studied. The