윤경림 교수

Purpose:This study was to examine the relations of perception of physique with self-esteem, sociality and problematic behaviors in children. Methods: Four hundred sixty five (231 boys and 234 girls) children were divided into three groups according to their height or body mass index according to the physical growth standard table had been presented in 2007 by the Korean Pediatric Society. The group 1, 2, and 3 was short, borderline and normal or obese, overweight and normal, respectively. Their

The genetic alterations of vitamin D receptor (VDR) are related with the growth of long bone. There were a lot of reports regarding an association of polymorphisms in the VDR promoter with many disorders, but not with idiopathic short stature (ISS). We investigated the association of them with ISS. A total of 50 subjects, including 29 ISS patients and 21healthy controls with their heights within the normal range was recruited. We selected two single nucleotide polymorphisms (SNPs) from VDR promo

In order to perform large-scale genetic studies of Kawasaki disease (KD) in Korea, the Korean Kawasaki Disease Genetics Consortium(KKDGC) was formed in 2008 with 10 hospitals. Since the establishment of KKDGC, there has been a collection of clinical data from atotal of 1198 patients, and approximately 5 mL of blood samples per patient (for genomic deoxyribonucleic acid and plasma isolation),using a standard clinical data collection form and a nation-wide networking system for blood sample pick-u

Background and Objectives: Patients with Kawasaki disease (KD) are clinically heterogeneous because its diagnosis is based solely on clinical observation and there are no definitive biomarkers. We dissected the clinical heterogeneity of KD patients using the KD-associated genetic variants. Methods: We performed a genetic association analysis in several KD subgroups categorized by clinical characteristics using the KD-associated variants of the B lymphoid tyrosine kinase (BLK; rs6993775) and Fc g

Background and Objectives: This was a multicenter study to evaluate the usefulness of the tumor necrosis factor-alpha (TNF-α) blocker infliximab for treatment of Korean pediatric patients with refractory Kawasaki disease (KD). Subjects and Methods: Data from 16 patients throughout Korea who were diagnosed with refractory KD and received infliximab were collected retrospectively. Results: Complete response to therapy with cessation of fever occurred in 13 of 16 patients. C-reactive protein (CRP)

목적 : 3세 이하에서 Mycoplasma pneumoniae 폐렴은 드문 것으로 알려져 있으나 최근 영유아에서도 Mycoplasma pneumoniae 폐렴이 많이 발생되고 있어서 3세 이하에서의 Mycoplasma pneumoniae 폐렴의 임상적 특성을 알아보고자 하였다. 방법 : 1994년 1월부터 1997년 12월까지 4년간 경희대학교 부속병원 소아과에 입원한 환 아 중 Mycoplasma pneumoniae 폐렴으로 진단된 3세 이하 환아 30명을 대상으로 의무기록 을 후향적으로 조사하여 임상양상, 혈청학적 소견, 방사선 소견, 합병증 및 치료 효과를 비 교 분석 하였다. 결과. 1) 3세 이하에서 폐렴으로 입원한 환아 235명중 30명(12.7%)이 Mycoplasma pneumoniae 폐렴이었고 남녀비는 1.3 : 1로 남아에서 다소 높았다. 2) 발생시기는 여름 및 가을, 초겨울에 걸쳐 넓게 분포하였고 1994년과 1997년에 호발하 였다. 3

목 적 : 가와사키병은 극동아시아인에서 다른 인종보다 높은 발생빈도를 보이고 여러 유전자 다형성이 보고되고 있다. COMT 는 염색체 22q11에 위치한 유전자로 메틸기접합을 촉진시켜 도파민, 에피네프린, 노르에피네프린 같은 카테콜아민 신경전달 물질을 불활성화 시키는 역할을 한다. COMT 유전자의 다형성은 estradiol 대사와 연관되어 혈압과 심근경색 등 심장질환과의 연관성이 보고되었고, 급성 관상동맥 질환과 관련이 있다고 보고되었다. 이 연구에서는 가와사키병에서 관상동맥 확장과 COMT 유전자 다형성과의 연관성을 알아보고자 하였다. 방 법 : 가와사키병 환자군 101명과 대조군 306명으로부터 혈액 2 mL를 채취하여 DNA를 분리하였으며, PCR 방법으로 COMT 유전자의 rs4680과 rs769224의 Guanine에서 Adenine으로의 단일염기다형성(SNP)을 분석하였다. 환자군 중 관상동맥의 확장을 동반한 37명과 관상동맥 확장이 없는 62명 대상으로 COMT 유전자

Purpose: Transforming growth factor beta receptor 2 (TGFBR2) is a tumor suppressor gene that plays a role in the differentiation of striated cells and remodeling of coronary arteries. Single nucleotide polymorphisms (SNPs) of this gene are associated with Marfan syndrome and sudden death in patients with coronary artery disease. Cardiovascular remodeling and T cell activation of TGFBR2 gene suggest that the TGFBR2 gene SNPs are related to the pathogenesis of Kawasaki disease (KD) and coronary ar

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children, and canresult in coronary artery lesions (CAL). A patient with KD who is resistant to treatment with intravenousimmunoglobulin (IVIG) has a higher risk of developing CAL. Incomplete KD has increased in prevalencein recent years, and is another risk factor for the development of CAL. Although the pathogenesis of KDremains unclear, there has been increasing evidence for the role of genetic susceptibility to

Background and Objectives: Intravenous immunoglobulin-SN (IVIG-SN) is a new human immunoglobulin product. Its safety is ensured by pathogen-elimination steps comprising solvent/detergent treatment and a nanofiltration process. This multicenter clinical study was designed to evaluate the efficacy and safety of combined aspirin and high-dose IVIG-SN therapy in pediatric patients with Kawasaki disease (KD). Subjects and Methods: We evaluated coronary artery lesions (CALs) at 2 and 7 weeks after adm

Purpose: In Kawasaki disease (KD) patients, coronary artery complications, incomplete and refractory types occur more frequently in patients with streptococcal or other bacterial/viral infections. Recently, we observed a higher incidence of coronary lesions in KD patients with high anti-streptolysin O (ASO) titer. Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognosis, with respect to treatment response and development of coronary artery

목 적 : 기관지 천식은 소아에서 가장 흔한 만성 질환이고, 소아의 급성 천식으로 인한 입원률은 매년 증가추세에 있으며, 이중 상당부분은 재입원률의 증가에 기인한다. 재입원의 위험이 높은 환아를 선별하여 적극적으로 치료하는 것이 치료 효과를 향상시키고 비용 절감의 효과도 클 것으로 사료되어, 본 연구에서는 소아 기관지 천식의 입원례에서 재입원에 영향을 미치는 위험인자를 알아보고자 하였다.방 법 : 1996년 3월부터 1997년 2월까지 1년동안 경희의대 부속병원 소아과에 기관지 천식으로 입원했던 14세 미만의 환아 95명을 대상으로 하여, 2회 이상 입원한 환아(연구군)과 초회 입원한 환아(대조군)로 나누어 입원 당시의 여러 변수들에 대해 병록지를 통해 후향적 방법으로 조사하였다.

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Chest pain is a very common symptom in pediatric patients. Although children with chest pain are relatively unlikely to be suffering from significant cardiac diseases, it is important not to overlook life-threatening diseases. Complete history taking and physical examination––which involves identifying the duration of pain, onset, character, associated symptoms, and aggravating factors––are extremely important. The most common causes of pediatric chest pain are idiopathic and musculoskeletal, wh