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이홍기 교수

Lee Hong-gi

한양대학교 외과 · 공학

연구실 소개

이홍기 교수의 연구실은 나노광학 및 플라즈몬 공진 현상을 활용한 초해상도 분광 영상 기술을 핵심으로 연구를 전개하고 있습니다. 특히, 표면 플라즈몬을 이용한 라만 분광법을 기반으로 생체세포 내 분자의 정밀 분포를 측정하고, 초해상도 영상 복원 기법을 통해 분자의 위치와 농도를 고해상도로 분석합니다. 또한, 나노구조 기반의 광학 센서와 온도 제어 가능한 플라즈몬 나노소재의 설계 및 응용에 관한 기초 연구도 진행 중입니다.

초해상도 영상플라즈몬 공진라만 분광법나노광학온도 제어 센서

연구 현황

논문 수
77
총 인용 수
491
최근 5년 논문
28
주요 분야
공학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
28총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
57총합
20222023202420252026

주요 논문

15
1
논문|인용수 67·2012
SAFE: Formal Specification and Implementation of a Scalable Analysis Framework for ECMAScript
Hongki Lee, Sooncheol Won, Joonho Jin, Junhee Cho, Sukyoung Ryu

The prevalent uses of JavaScript in web programming have revealed security vulnerability issues of JavaScript applications, which emphasizes the need for JavaScript analyzers to detect such issues. Recently, researchers have proposed several analyzers of JavaScript programs and some web service companies have developed various JavaScript engines. However, unfortunately, most of the tools are not documented well, thus it is very hard to understand and modify them. Or, such tools are often not ope

Artificial IntelligenceComputer Science
2
논문|인용수 36·2020
Surface Plasmon Localization-Based Super-resolved Raman Microscopy
Hongki Lee, Kyungnam Kang, Kentaro Mochizuki, Chang‐Hun Lee, Kar‐Ann Toh, Seung Ah Lee, Katsumasa Fujita, Donghyun Kim
SJR Q1Nano Letters

We investigate label-free measurement of molecular distribution by super-resolved Raman microscopy using surface plasmon (SP) localization. Localized SP was formed with plasmonic nanopost arrays (PNAs) for measurement of the molecular distribution in HeLa cells. Compared with conventional Raman microscopy on gold thin films, PNAs induce a localized near-field, which allows for the enhancement of the peak signal-to-noise ratio by as much as 4.5 dB in the Raman shifts. Super-resolved distributions

BiophysicsBiochemistry, Genetics and Molecular Biology
3
논문|인용수 33·2021
Super-resolved Raman microscopy using random structured light illumination: Concept and feasibility
Hongki Lee, Hajun Yoo, Gwiyeong Moon, Kar‐Ann Toh, Kentaro Mochizuki, Katsumasa Fujita, Donghyun Kim
SJR Q1The Journal of Chemical Physics

In this article, we report the use of randomly structured light illumination for chemical imaging of molecular distribution based on Raman microscopy with improved image resolution. Random structured basis images generated from temporal and spectral characteristics of the measured Raman signatures were superposed to perform structured illumination microscopy (SIM) with the blind-SIM algorithm. For experimental validation, Raman signatures corresponding to Rhodamine 6G (R6G) in the waveband of 73

BiophysicsBiochemistry, Genetics and Molecular Biology
4
논문|인용수 19·2021
Label-free detection of single nanoparticles with disordered nanoisland surface plasmon sensor
Hongki Lee, Joel Berk, Aaron Webster, Donghyun Kim, Matthew R. Foreman
SJR Q2NanotechnologyOA

We report sensing of single nanoparticles using disordered metallic nanoisland substrates supporting surface plasmon polaritons (SPPs). Speckle patterns arising from leakage radiation of elastically scattered SPPs provide a unique fingerprint of the scattering microstructure at the sensor surface. Experimental measurements of the speckle decorrelation are presented and shown to enable detection of sorption of individual gold nanoparticles and polystyrene beads. Our approach is verified through b

Biomedical EngineeringEngineering
5
논문|인용수 17·2015
Sub-10 nm near-field localization by plasmonic metal nanoaperture arrays with ultrashort light pulses
Hongki Lee, Chulhong Kim, Donghyun Kim
SJR Q1Scientific ReportsOA

Near-field localization by ultrashort femtosecond light pulses has been investigated using simple geometrical nanoapertures. The apertures employ circular, rhombic, and triangular shapes to localize the distribution of surface plasmon. To understand the geometrical effect on the localization, aperture length and period of the nanoapertures were varied. Aperture length was shown to affect the performance more than aperture period due mainly to intra-aperture coupling of near-fields. Triangular ap

Biomedical EngineeringEngineering
6
논문|인용수 12·2021
Plasmon-enhanced fluorescence correlation spectroscopy for super-localized detection of nanoscale subcellular dynamics
Hongki Lee, Woo Joong Rhee, Gwiyeong Moon, Seongmin Im, Taehwang Son, Jeon‐Soo Shin, Donghyun Kim
SJR Q1Biosensors and BioelectronicsOA
BiophysicsBiochemistry, Genetics and Molecular Biology
7
논문|인용수 9·2024
Probing Temperature-Induced Plasmonic Nonlinearity: Unveiling Opto-Thermal Effects on Light Absorption and Near-Field Enhancement
Hongki Lee, Seongmin Im, Chang‐Hun Lee, Hyunwoong Lee, Shi‐Wei Chu, Ho‐Pui Ho, Donghyun Kim
SJR Q1Nano Letters

Precise measurement and control of local heating in plasmonic nanostructures are vital for diverse nanophotonic devices. Despite significant efforts, challenges in understanding temperature-induced plasmonic nonlinearity persist, particularly in light absorption and near-field enhancement due to the absence of suitable measurement techniques. This study presents an approach allowing simultaneous measurements of light absorption and near-field enhancement through angle-resolved near-field scannin

Biomedical EngineeringEngineering
8
논문|인용수 3·2025
Super-Resolution Raman Scattering Imaging Enabled by Rough Metal Films
Hongki Lee, Ming Lei, Junxiang Zhao, Guanghao Chen, Jie Hu, Zachary Burns, Fanglin Tian, Zhaowei Liu
SJR Q1Nano Letters

A super-resolution Raman scattering microscopy technique is demonstrated by combining localized surface plasmon-based structured illumination microscopy with the blindSIM algorithm. This approach enables super-resolution Raman scattering imaging of dielectric nanoparticles with sub-100 nm resolution. The technique leverages the surface-enhanced Raman scattering effect of rough silver films to generate near-field speckle patterns, enabling subdiffraction-limited optical sampling and enhanced Rama

BiophysicsBiochemistry, Genetics and Molecular Biology
9
논문|인용수 2·2025
Random Metastructures for Nanoscale Visualization of Single-Exosome Dynamics in a Gut–Brain-Axis-on-a-Chip
Hongki Lee, Gwang Myeong Seo, Hajun Yoo, Gwiyeong Moon, Hyunwoong Lee, Zhaowei Liu, Jong Hwan Sung, Donghyun Kim
SJR Q1ACS Nano

This study introduces an innovative nanophotonic biosensor system designed to explore exosome dynamics within the gut-brain axis, highlighting the bidirectional and biochemical communication between the gastrointestinal tract and the central nervous system. The proposed system incorporates coculture environments for various cell types, microfluidic control of exosomes, and super-resolution imaging capabilities for both exosomes and live cells. While enabling real-time observation of long-range e

Molecular BiologyBiochemistry, Genetics and Molecular Biology
10
논문|인용수 0·2026
Metasurface-enhanced dark-field interferometric scattering microscopy
Hongki Lee, Junxiang Zhao, Pan Hu, Zhaoyu Nie, Ming Lei, Guanghao Chen, Soojeong Baek, Qianyi Wu, Li Chen, Ang Leo Li, Man Luo, Shizhen Emily Wang
Acoustics and UltrasonicsPhysics and Astronomy
11
논문|인용수 0·2018
Ultrasensitive colocalization detection based on plasmonic nanolithography with molecular-overlapped optical near-fields
Hongki Lee, Donghyun Kim, Young-Jin Oh, Taehwang Son, Ki-Heung Kim, Dong Ha Kim, Yun‐Feng Xiao, Wonju Lee, Kyungwha Chung

The detection sensitivity of surface plasmon resonance (SPR) biosensors has been improved by employing colocalization of spatial distribution of electromagnetic near-fields and detection molecules. We have used plasmon nanolithography to achieve light-matter colocalization on triangular nanoaperture arrays and optimized array configurations to improve colocalization efficiency. Streptavidin-biotin interactions were measured to validate the concept. It was confirmed that colocalized distributions

Biomedical EngineeringEngineering
12
논문|인용수 0·2023
Nanospeckle Illumination Microscopy of Extracellular Vesicles on Chip
Hongki Lee, Hajun Yoo, Gwang Myeong Seo, Kyungnam Kang, Seung Ah Lee, Kar‐Ann Toh, Jong Hwan Sung, Donghyun Kim

We present structured illumination microscopy based on random nanospeckle distributions of light fields localized by plasmonic nanoislands. Images were acquired of exosomes on biochips for super-resolved reconstruction. The results confirm improved image resolution below the diffraction limit.

Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
book chapter|인용수 0·2019
Design and Applications of Optical Near-Field Antenna Networks for Nanoscale Biomolecular Information
Hongki Lee, Hyunwoong Lee, Gwiyeong Moon, Donghyun Kim

This chapter presents near-field and far-field characteristics of nanoantenna networks and showed that signal propagation can be performed using diverse architectures. Nanoantennas refer to nanoscale transducers that convert electric energy into electromagnetic (EM) wave propagation as a transmitting antenna in a communication channel, with low energy loss, working at optical frequencies. EM radiation from nanoantenna induces near-field distribution on a wavelength spatial scale, which undergoes

Biomedical EngineeringEngineering
14
논문|인용수 0·2019
Fluorescence correlation spectroscopy using an optical scattering probe based on plasmonic dimer antenna arrays (Conference Presentation)
Hongki Lee, Donghyun Kim, Seongmin Im, Gwiyeong Moon

We have investigated the excitation of fluoresce molecules using nanoscale light confinement on the plasmonic nanostructures. We have fabricated gold nano-dimer arrays whose diameter and height were 100 and 20 nm respectively on 20-nm gold film with BK7 substrate with a period of 746 nm. We have calculated the field distribution by three dimensional finite-difference time-domain (FDTD) method and confirmed the field localization on the dimer’s gap whose size was 18 nm. The field confinement was

Biomedical EngineeringEngineering
15
논문|인용수 0·2020
Gap plasmon-based fluorescence correlation spectroscopy for anomalous molecular diffusion
Hongki Lee, Donghyun Kim, Gwiyeong Moon, Seongmin Im

We demonstrated gold nanodimer arrays could improve the signal-to-noise ratio (SNR) of fluorescence correlation spectroscopy (FCS). In this research, we explore the feasibility of plasmon-enhanced FCS for biomolecular study using a nanodimer array whose gap size was 18 nm. Fluorescence nanobead with a diameter of 40 nm was first examined to verify if gold nanodimer arrays can enhance SNR of fluorescence and scattering intensities. We emphasize that plasmon-enhanced FCS can improve the precision

BiophysicsBiochemistry, Genetics and Molecular Biology

대표 연구 분야

Biomedical EngineeringBiophysicsMolecular BiologyAcoustics and UltrasonicsAerospace EngineeringElectrical and Electronic Engineering

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