정민형 교수

In periodontal diseases, inflammatory mediators, including interleukin (IL)-6, IL-8 and tumor necrosis factor-α (TNF-α), may promote the degeneration of inflamed periodontal tissues. In previous studies, levels of these three cytokines were demonstrated to be elevated in inflammatory gingival tissues and gingival crevicular fluid. The aim of the present study was to quantify IL-6, IL-8 and TNF-α levels in the human gingival tissues of patients with periodontitis and to assess the correlation of

The death process of Candida albicans was investigated after treatment with the antifungal agents flucytosine and amphotericin B by assessing morphological and biophysical properties associated with cell death. C. albicans was treated varying time periods (from 6 to 48 hours) and examined by scanning electron microscopy (SEM) and atomic force microscopy (AFM). SEM and AFM images clearly showed changes in morphology and biophysical properties. After drug treatment, the membrane of C. albicans was

BACKGROUND: Single-port laparoscopic-assisted vaginal hysterectomy (S-LAVH) uses only one transumbilical incision site and has better cosmetic result than conventional multiport LAVH. This study aimed to evaluate our initial experience with S-LAVH compared with the more conventional three-port LAVH in women with benign uterine diseases. METHODS: Between April 2009 and April 2010, S-LAVH was attempted on 183 patients with benign uterine diseases through a transumbilical incision for a 12-mm troca

Actinomycosis is a chronic disease characterized by abscess, tissue fibrosis and draining sinuses. Pelvic actinomycosis in women most commonly occurs during ascending infections, which are usually associated with intrauterine devices; however, secondary hepatic actinomycosis, while rare, can also occur. We describe a patient with an unusual case of metastatic hepatic actinomycosis misdiagnosed as distant metastases of ovarian cancer.

Castleman's disease is a rare benign lymphoproliferative disease. We describe a patient with an unusual case of retroperitoneal Castleman's disease who initially presented with hydronephrosis. Her disease manifested with a malignant appearance in positron emission tomography/computed tomography and was located in the common and internal iliac area. Retrograde double-J stent insertion failed and nephrostomy was then performed. Complete surgical removal of the disease failed because the disease wa

RATIONALE: Advanced ovarian malignancies are associated with poor overall survival; thus, patients often turn to alternative treatments, despite the controversy surrounding their use. Mistletoe extract has been commonly used as complementary medicine to treat patients with cancer for several decades, and has proven benefits in integrative oncology. PATIENT CONCERNS: A 47-year-old woman with stage IVB ovarian cancer who underwent optimal surgical cytoreduction, but whose disease persisted after a

It is known that pre-eclampsia affects the structure of the umbilical cord including changes in diameter and wall thickness. In this work, the morphological changes of umbilical cords associated with pre-eclampsia were investigated using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The SEM images showed the overall structural changes in the umbilical cord, and the AFM imaged the surface of the cord in the nanometer range. The amount of Wharton's jelly was reduced in the

본 증례는 무월경, 요추부 통증, 하지 부종을 호소하는 32세 여성에서 증상의 발생, 진단 및 치료에 대한 것으로 환자는 2번 요추의 압박골절, 원인불명의 양하지 부종, 심한 골다공증을 보였다. 환자는 골다공증의 원인에 대해 여러 전문 진료과에 협진 의뢰 후 부신 선종에 의한 쿠싱증후군으로 진단되었다. 부신절제술, 물리치료, 약물 치료를 통해 골다공증의 진행을 예방하였다.

Multiresistente Erreger (MRSA, VRE und ESBL) stellen in zunehmendem Maße ein Problem für medizinische Einrichtungen dar. Unter den HA-MRSA(health care associated MRSA)-Trägern gilt eine < 12 Monate zurückliegende endoskopische Untersuchung als ein möglicher Übertragungs­weg. Neben Bronchoskopien besitzt die perkutane endoskopische Gastrostomie wegen der oro-pharyngealen Besiedelung ein beträchtliches Kontaminationsrisiko. Da die Keime in der Umwelt lange persistieren, sind bei Kontakt mit MRSA-P

외음부 악성 흑색종은 전체 외음부 악성 종양의 10%를 차지하는 드문 질환으로 5년 생존율은 8-54%이고 주로 폐경 후 백인 여성에게 발생한다. 다른 피부의 악성 흑색종과 비교하여 외음부의 악성 흑색종은 조기에 조직 또는 림프절, 혈관에 침윤되기 때문에 그 예후는 대부분에서 불량하고 침윤 깊이가 예후를 판정하는 가장 중요한 인자로 여겨진다. 이전에는 광범위한 침습적 수술과 림프절 절제가 유용한 수술로 여겨져 왔으나 생명 연장에 도움이 되지 않아 최근에는 이전의 광범위한 수술 대신 덜 침습적이 수술이 행해지고 있다.

6025 Several different approaches have been used to expand and activate human umbilical cord blood (UCB) T cells ex vivo for infusion into patients with various cancers and infectious diseases. This study was designed to establish a more effective and safe culture system for the ex vivo expansion, maturation and activation of human UCB T cells by investigating the use of autologous or homologous cord blood plasma (ACBP, HCBP), instead of fetal bovine serum (FBS). We collected 36 UCB samples at t

Objective: To evaluate the clinical and pathological characteristics of endodermal sinus tumor (EST) of the ovary. Methods: Seventeen patients who were treated with EST of the ovary between September 1991 and February 2005 were reviewed retrospectively for clinicopathologic characteristics, treatments, and outcomes. Results: Median age at diagnosis was 22.0 years (range 7-43). Nine patients (52.9%) were stage I, 3 (17.6%) stage II, 4 (23.5%) stage III, and 1 (5.9%) stage IV. Twelve of 17 patient