김민경 교수
Min-kyung Kim
이화여자대학교 환경공학과 · 생화학·유전·분자생물학
연구실 소개
김민경 교수의 연구실은 생물정보학과 계산생물학을 융합하여 유전자 발현 데이터를 바탕으로 세포 내 대사 유량을 정밀하게 예측하는 기계학습 기반의 대사 모델링 기법을 개발하고 있습니다. 특히, 다세포 생물, 특히 다이아톰과 같은 유전자 편집이 가능한 미세조류의 대사 경로를 체계적으로 분석함으로써 지속 가능한 바이오연료 생산의 과학적 기반을 마련하고자 합니다. 또한, 자연어 처리 기술을 활용해 온라인 리뷰의 구체적 속성에 대한 감성 평가를 정교하게 분석하는 방법론 개발도 함께 진행하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Abstract This study conceptualizes lexical sophistication as a multidimensional phenomenon by reducing numerous lexical features of lexical sophistication into 12 aggregated components (i.e., dimensions) via a principal component analysis approach. These components were then used to predict second language (L2) writing proficiency levels, holistic lexical proficiency scores, and longitudinal lexical growth. The results from regression analyses indicated that 5 lexical components (i.e., bigram an
This study investigates the relationship between the nuclear power proportion and CO2 emissions per capita using the panel dynamic ordinary least square method. The panel datasets consist of 18 countries covering 95% of the global nuclear reactors. The results indicate that a long-term 1% increase in nuclear power led to a 0.26–0.32% decrease in CO2 emissions per capita. Additionally, in France, Germany, and Switzerland they demonstrate the existence of the environmental Kuznets curve—an inverte
Several computational methods have been developed that integrate transcriptomic data with genome-scale metabolic reconstructions to infer condition-specific system-wide intracellular metabolic flux distributions. In this mini-review, we describe each of these methods published to date with categorizing them based on four different grouping criteria (requirement for multiple gene expression datasets as input, requirement for a threshold to define a gene's high and low expression, requirement for
The authors address two significant challenges in using online text reviews to obtain fine-grained, attribute-level sentiment ratings. First, in contrast to methods that rely on word frequency, they develop a deep learning convolutional–long short-term memory hybrid model to account for language structure. The convolutional layer accounts for spatial structure (adjacent word groups or phrases), and long short-term memory accounts for the sequential structure of language (sentiment distributed an
Diatoms (Bacillarophyceae) are photosynthetic unicellular microalgae that have risen to ecological prominence in oceans over the past 30 million years. They are of interest as potential feedstocks for sustainable biofuels. Maximizing production of these feedstocks will require genetic modifications and an understanding of algal metabolism. These processes may benefit from genome-scale models, which predict intracellular fluxes and theoretical yields, as well as the viability of knockout and knoc
Our method represents a significant advance over existing methods for inferring intracellular metabolic flux from transcriptomic data. It not only achieves higher accuracy, but it also combines into a single method a number of other desirable characteristics including applicability to a wide range of experimental conditions, production of a unique solution, fast running time, and the availability of a user-friendly implementation.
Abstract Genome-wide association study (GWAS) is effective in identifying favorable alleles for traits of interest with high mapping resolution in crop species. In this study, we conducted GWAS to explore quantitative trait loci (QTL) for eight fruit traits using 162 tomato accessions with diverse genetic backgrounds. The eight traits included fruit weight, fruit width, fruit height, fruit shape index, pericarp thickness, locule number, fruit firmness, and brix. Phenotypic variations of these tr
Clozapine is an antipsychotic drug that has a greater efficacy than other medications in some contexts, especially for the treatment of treatment-resistant schizophrenia. However, clozapine induces more metabolic side-effects involving abnormality in lipid metabolism compared to other antipsychotics. AMP-activated protein kinase (AMPK) plays a central role in controlling lipid metabolism through modulating the downstream acetyl CoA carboxylase (ACC) and carnitine palmitoyl transferase 1 (CPT1) p
At many firms, incentivized salespeople with private information about customers are responsible for customer relationship management. Although incentives motivate sales performance, private information can induce moral hazard by salespeople to gain compensation at the expense of the firm. The authors investigate the sales performance–moral hazard trade-off in response to multidimensional performance (acquisition and maintenance) incentives in the presence of private information. Using unique pa
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