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With many novel targeted therapies currently in development for soft tissue sarcomas, a better understanding of the molecular pathogenesis and aberrations of HPC/SFT is needed to determine optimal therapeutic agents. Identifying appropriate targets and designing rational prospective clinical trials will not only improve treatment of HPC/SFT but will also lead to a new paradigm of personalized, targeted therapy.

The nitric oxide (NO)-protein kinase G (PKG) pathway has been known for some time to be an important target for cardioprotection against ischaemia/reperfusion injury and heart failure. While many approaches for reducing infarct size in patients have failed in the past, the advent of novel drugs that modulate cGMP and its downstream targets shows very promising results in recent preclinical and clinical studies. Here, we review main aspects of the NO-PKG pathway in light of recent drug developmen

AIM: We investigated the significance of the calculated delta neutrophil index (DNI) as a diagnostic factor for neonatal sepsis. METHODS: In retrospective study, 24 infants were diagnosed with blood culture-proven sepsis, and 48 non-septic neonates matched for gestational age, and birth weight served as controls. Among the 24 infants with sepsis, 5 died within 7 days at diagnosis. RESULTS: Mean DNI (at diagnosis, after 24 h and 72 h), CRP and WBC counts were significantly higher, and neutrophil

PURPOSE: To evaluate the efficacy of endoscopic endonasal primary conjunctivodacryocystorhinostomy (CDCR) and revision CDCR after primary CDCR. METHODS: Twenty-four patients who had undergone endoscopic endonasal CDCR with a Jones tube and who were followed up for over 6 months at our hospital were reviewed retrospectively. Our analysis included success rate, operation times, and causes of failure. RESULTS: The indications for revision CDCR were Jones tube prolapse and inadequate tube length. Th

PURPOSE: To evaluate the clinical efficacy of a simplified single-suture inferior retractor repair technique for involutional entropion. METHODS: A retrospective study of 20 patients (26 eyelids), followed for 6 months at our hospital, who showed no severe horizontal lid laxity were operated on for involutional entropion. After subciliary incision, the inferior retractor was identified and repaired by reattaching the superior edge of the inferior retractor to the inferior edge of the lower tarsu

Aplasia cutis congenita is a heterogeneous group of conditions usually involving the scalp as well as any other part of the body and is associated with a number of other congenital anomalies. We report on a newborn male with almost complete absence of skin and subcutaneous tissue in association with choanal atresia, syndactyly, imperforate anus, pulmonary hypoplasia, and other anomalies. To our knowledge, this condition, not only in the extent of the lesion but the associated anomalies, has not

In our study, fracture size was a better predictive factor for postoperative enophthalmos than preoperative exophthalmometric measurement. With our method, postoperative enophthalmos can be predicted more conveniently in a clinical setting, and decisions regarding the timing of early surgical reduction were made easier.

Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety profiles after coadministration of clarithromycin, amoxicillin, and ilaprazole. A randomised, open-label, one-way crossover, two parallel sequences study was conducted in 32 healthy subjects. In part 1, the subjects received a single dose of ilaprazole 10 mg