김민정 교수

Autophagy has recently been implicated in both the prevention and progression of cancer. However, the molecular basis for the relationship between autophagy induction and the initial acquisition of malignancy is currently unknown. Here, we provide the first evidence that autophagy is essential for oncogenic K-Ras (K-Ras(V12))-induced malignant cell transformation. Retroviral expression of K-Ras(V12) induced autophagic vacuole formation and malignant transformation in human breast epithelial cell

In the fungal pathogen Candida albicans, the yeast-to-hyphal transition occurs in response to a broad range of environmental stimuli and is considered to be a major virulence factor. To address whether the zinc homeostasis affects the growth or pathogenicity of C. albicans, we functionally characterized the zinc-finger protein Csr1 during filamentation. The deduced amino acid sequence of Csr1 showed a 49% similarity to the zinc-specific transcription factor, Zap1 of Saccharomyces cerevisiae. Seq

STUDY DESIGN: Retrospective cohort study of a nationwide database. OBJECTIVE: The primary objective was to summarize the use of surgical methods for lumbar herniated intervertebral disc disease (HIVD) at two different time periods under the national health insurance system. The secondary objective was to perform a cost-effectiveness analysis by utilizing incremental cost-effectiveness ratio (ICER). SUMMARY OF BACKGROUND DATA: The selection of surgical method for HIVD may or may not be consistent

STUDY DESIGN: A retrospective cohort study. OBJECTIVE: The objectives of the present study were to examine the changes in the number of surgeries, surgical methods selected, and reoperation rates between the years 2003 and 2008. SUMMARY OF BACKGROUND DATA: The selection of the appropriate surgical method between decompression-only (D) and decompression plus fusion (DF) represents a challenging clinical dilemma in patients with degenerative lumbar spinal spondylolisthesis. DF is selected in great

Obesity is one of the most serious health problems in developed countries. It negatively affects diverse aspects of human wellbeing. Of these, a relationship between obesity and depression is widely recognized but biomarkers for assessment of obesityassociated mood changes in animal obesity models are rarely known. Here we explored the link between obesity and the plasma levels of monoamine neurotransmitters involved in mood control using a sensitive UPLC/MSMS technique in high fat diet (HFD)- i

BACKGROUND AND OBJECTIVES: This study was conducted to investigate the impact of polymorphisms in the AKT1 gene on the survival of early stage non-small cell lung cancer (NSCLC) patients. METHODS: Three hundred and ten patients with surgically resected NSCLC were enrolled. The rs3803300, rs1130214, rs3730358, rs1130233, and rs2494732 single nucleotide polymorphisms (SNPs) in the AKT1 gene were investigated. The genotype and haplotype associations with overall survival (OS) and disease free survi

BACKGROUND: The efficacy of antiretroviral therapy (ART) has improved, and the adverse effects of antiretroviral drugs have been reduced. However, these adverse effects still significantly influence patient compliance, increasing the risk of tolerability failure. Therefore, we investigated the adverse effects and tolerability failure causing changes in the first ART regimen, and identified the regimens that were most vulnerable to switching. MATERIALS AND METHODS: We enrolled patients with human

In this paper, we propose a general framework for performance improvement of the current state-of-the-art registration algorithms in terms of both accuracy and computation time. The key concept involves rapid prediction of a deformation field for registration initialization, which is achieved by a statistical correlation model learned between image appearances and deformation fields. This allows us to immediately bring a template image as close as possible to a subject image that we need to regi

The purpose of this study was to examine the relation between forms of children's solitary play and temperament, problem behaviors. Seventy-six children of four-year-olds were observed during free play. Children's temperament was measured by mothers of participants. Children's problem behaviors were measured by teachers. Following from Coplan et al(1994), this study were analyzed three aggregate measures of solitary play consisting of reticent behavior, solitary-passive play, and solitary-active

본 연구는 스마트폰을 통한 트위터의 이용이 온라인과 오프라인에서의 관계 형성에 미치는 영향에 대해 검증하였다. 구체적으로, 트위터 이용 정도가 지각된 상호작용에 미치는 영향, 지각된 상호작용성이 긍정적 온라인 관계형성에 미치는 영향, 긍정적 온라인 관계가 오프라인 관계 형성에 미치는 영향에 대해서 알아보았다. 280명의 트위터 이용자들을 설문조사한 결과, 트위터 이용과 지각된 상호작용성 사이에는 부분적으로 유의미한 상관관계가 나타났다. 즉, 트위터에서의 대화 빈도가 높을수록 쌍방향성, 반응성, 연결성, 이동성을 높게 지각하였다. 연구에서는 또한, 트위터 사용자의 지각된 상호작용성이 온라인 관계 형성에 긍정적인 영향을 미치는 것으로 나타났고, 스마트폰을 통한 온라인 관계 형성은 오프라인 관계 형성에 긍정적 영향을 미치는 것으로 밝혀졌다. 트위터를 하면서 느끼는 놀이성은 온라인 관계를 넘어서 다른 이용자와 심리적으로 가깝다고 인지하는 내적인 오프라인 관계를 형성하는데 긍정적인 영향을 미

본 연구에서는 멘토링 네트워크가 조직 내 개인들에게 미치는 효과성을 연구하고자 하였다. 본 연구의 목적은 첫째, 멘토링 네트워크의 특성(관계 강도, 범위, 크기)이 멘토링 기능, 즉 경력기능과 심리사회기능에 미치는 영향을 탐구하는 것이다. 둘째, 사회 네트워크의 효과를 설명하는 관점들 중에서 배태성 관점과 다양성 관점이 서로 대립적 개념이 아니라 양립할 수 있는 독립된 관점들이며, 배태적 관계와 다양한 관계를 함께 추구할 수 있음을 밝히고자 하였다. 이를 위해 1개 조직 내부의 군 관리자들을 대상으로 비공식 멘토링 네트워크를 측정하는 설문조사 및 일반 설문조사를 실시하였다. 가설 검증을 위한 사회 네트워크 분석과 위계적 회귀분석 결과, 관계 강도와 네트워크 범위가 멘토링의 경력기능 및 심리사회기능 모두와 유의미한 정(+)의 관계를 지니는 것으로 나타났다. 그러나 기대했던 네트워크 크기와 멘토링 기능 사이의 역U형의 관계는 지지되지 않았다. 본 연구는 멘토링 네트워크의 효과성을 검증함