김문기 교수
Moon Ki Kim
성균관대학교 기계공학부 · 공학
연구실 소개
김문기 교수의 연구실은 나노소재 및 생체분자 시스템의 구조-기능 관계를 해석하고자, 고해상도 분석 기법과 분자 동역학 시뮬레이션을 융합한 연구를 수행하고 있습니다. 특히 그래핀의 손상 최소화 전이 기술, 수분 여과에 응용 가능한 아쿠아포린 모방형 그래핀 옥사이드 막, DNA 나노구조물의 다차원 정보 저장 메커니즘 등에서 기초적 원리를 규명하고 있습니다. 또한 단백질의 기계적 동역학과 기능적 변형 경로 예측을 위한 고도화된 에너지 네트워크 모델링 기법 개발을 통해 생체 분자의 기계적 특성과 기능적 운동을 정량적으로 분석하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Graphene films grown on metal substrates by chemical vapor deposition (CVD) method have to be safely transferred onto desired substrates for further applications. Recently, a roll-to-roll (R2R) method has been developed for large-area transfer, which is particularly efficient for flexible target substrates. However, in the case of rigid substrates such as glass or wafers, the roll-based method is found to induce considerable mechanical damages on graphene films during the transfer process, resul
Water purification by membranes is widely investigated to address concerns related to the scarcity of clean water. Achieving high flux and rejection simultaneously is a difficult challenge using such membranes because these properties are mutually exclusive in common artificial membranes. Nature has developed a method for this task involving water-channel membrane proteins known as aquaporins. Here, the design and fabrication of graphene oxide (GO)-based membranes with a surface-tethered peptide
The information capacity of DNA double-crossover (DX) tiles was successfully increased beyond a binary representation to higher base representations. By controlling the length and the position of DNA hairpins on the DX tile, ternary and senary (base-3 and base-6) digit representations were realized and verified by atomic force microscopy. Also, normal mode analysis was carried out to study the mechanical characteristics of each structure.
An elastic network model (ENM), usually Cα coarse-grained one, has been widely used to study protein dynamics as an alternative to classical molecular dynamics simulation. This simple approach dramatically saves the computational cost, but sometimes fails to describe a feasible conformational change due to unrealistically excessive spring connections. To overcome this limitation, we propose a mass-weighted chemical elastic network model (MWCENM) in which the total mass of each residue is assumed
The proposed frequency analysis method is a feasible method for understanding DNA nanostructure's vibration characteristics, including both frequencies and mode shapes in atomic detail, adding to the molecular fingerprint provided by the conventional Raman spectrum.
The biological function of proteins is closely related to its structural motion. For instance, structurally misfolded proteins do not function properly. Although we are able to experimentally obtain structural information on proteins, it is still challenging to capture their dynamics, such as transition processes. Therefore, we need a simulation method to predict the transition pathways of a protein in order to understand and study large functional deformations. Here, we present a new simulation
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