김묘정 교수

The radical-mediated C-H functionalization of pyridines has attracted considerable attention as a powerful tool in synthetic chemistry for the direct functionalization of the C-H bonds of the pyridine scaffold. Classically, the synthetic methods for functionalized pyridines often involve radical-mediated Minisci-type reactions under strongly acidic conditions. However, the site-selective functionalization of pyridines in unbiased systems has been a long-standing challenge because the pyridine sc

a three-component reaction, which provides facile access to a variety of β-pyridyl alkyl sulfones. These two reactions are orthogonal and complementary, achieving a broad substrate scope in a late-stage fashion under mild reaction conditions.

Abstract An efficient pyridylic C(sp 3 )−H functionalization has been developed through photocatalytic radical‐mediated fluoroalkylation or cascade reactions. This method is enabled by the reversible formation of alkylidene dihydropyridine intermediates via the facile enolate formation of C4‐alkyl N ‐amidopyridinium salts in the absence of an external base, thereby establishing the conditions necessary for subsequent intermolecular radical trapping. Rapid structural diversification of the pyridy

Organic dyes have been actively studied as useful photocatalysts because they allow access to versatile structural flexibility and green synthetic applications. The identification of a new class of robust organic chromophores is, therefore, in high demand to increase structural diversity and variability. Although coumarins and quinolinones have long been acknowledged as organic chromophores, their ability to participate in photoinduced transformations is somewhat less familiar. Fascinated by the

Abstract An efficient pyridylic C(sp 3 )−H functionalization has been developed through photocatalytic radical‐mediated fluoroalkylation or cascade reactions. This method is enabled by the reversible formation of alkylidene dihydropyridine intermediates via the facile enolate formation of C4‐alkyl N ‐amidopyridinium salts in the absence of an external base, thereby establishing the conditions necessary for subsequent intermolecular radical trapping. Rapid structural diversification of the pyridy

This study aims to predict the future flood damage cost of 113 middle range watersheds using 26 GCM outputs, hourly maximum rainfall, 10-min maximum rainfall, number of days of 80 mm/day, daily rainfall maximum, annual rainfall amount, DEM, urbanization ratio, population density, asset density, road improvement ratio, river improvement ratio, drainage system improvement ratio, pumping capacity, detention basin capacity and previous flood damage costs. A constrained multiple linear regression mod

Functional group interconversions of abundant substructures that accommodate the often-complex molecular architectures seen in pharmaceuticals are particularly sought after by medicinal chemists as a means to enable both lead optimization and library diversification. Here, we report a conceptually new strategy that enables net SO 2 -insertion into the C–N bond of primary amines, enabling the direct synthesis of primary sulfonamides without pre-activation and effectively inverting the nitrogen’s

Background: The Korean Pharmaceutical Information Service (KPIS) was established in October 2007 to increase the transparency of the pharmaceutical supply chain by integrating relevant information. This study aimed to describe the KPIS program and perform a cost-benefit analysis of the KPIS. Methods: We conducted a cost-benefit analysis based on cost savings in terms of National Health Insurance (NHI). The outcome measures were the net financial benefit and benefit-cost ratio over the 12 years s

Die selektive Installation funktioneller Gruppen an der Pyridylposition ist von großem Interesse in der synthetischen und medizinischen Chemie. In ihrem Forschungsartikel (e202204217) berichten Sungwoo Hong und Mitarbeiter über die erfolgreiche C-H-Funktionalisierung der heterobenzylischen Position von Pyridinen und Chinolinen mittels Kaskadenreaktionen auf einer modularen photochemischen Plattform. Diese Reaktion bietet ein leistungsfähiges Synthesewerkzeug für die rationale Modifizierung heter