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조명래 교수

MyoungLae Cho

경희대학교 유전생명공학과 · 농업·생명과학

연구실 소개

조명래 교수의 연구실은 천연물에서 유래한 생활학적 활성 성분, 특히 해조류 및 약용식물에서 추출한 폴리페놀, 플라보노이드, 히알루론산 유사 다당류(fucoidan) 등의 항산화 및 생리활성을 중심으로 연구를 진행하고 있습니다. 특히, 항산화 활성과 효소 억제 작용(아세틸콜린에스터라제, 모노아민산화효소 등)을 통해 신경퇴행성 질환 예방에 기여할 수 있는 물질의 규명에 초점을 맞추고 있으며, 식품 및 생체재료의 유리성질 제어를 위한 다당류의 륨적 거동 분석도 함께 수행하고 있습니다. 이와 같은 연구를 바탕으로 천연물 기반의 기능성 소재 개발과 건강기능식품, 의약품 신소재의 기초 연구를 선도하고 있습니다.

항산화 활성fucoidan효소 억제천연물식품소재

연구 현황

논문 수
52
총 인용 수
1,335
최근 5년 논문
22
주요 분야
농업·생명과학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
22총합
2017
2018
2019
2020
2021
5개년 연도별 피인용 수
482총합
20172018201920202021

주요 논문

15
1
논문|인용수 236·2011
Antioxidant properties of extract and fractions from Enteromorpha prolifera, a type of green seaweed
MyoungLae Cho, Hyi-Seung Lee, Il‐Jun Kang, Moo‐Ho Won, SangGuan You
SJR Q1Food Chemistry
Aquatic ScienceAgricultural and Biological Sciences
2
논문|인용수 88·2010
Molecular characterization and biological activities of watersoluble sulfated polysaccharides from Enteromorpha prolifera
MyoungLae Cho, Yang Chen, Sang Moo Kim, SangGuan You
SJR Q2Food Science and Biotechnology
Aquatic ScienceAgricultural and Biological Sciences
3
논문|인용수 82·2012
Characterization and immunomodulatory activities of sulfated polysaccharides from Capsosiphon fulvescens
Supatra Karnjanapratum, Mehdi Tabarsa, MyoungLae Cho, SangGuan You
SJR Q1International Journal of Biological Macromolecules
Aquatic ScienceAgricultural and Biological Sciences
4
논문|인용수 80·2010
The Antioxidant Properties of Ethanol Extracts and Their Solvent-Partitioned Fractions from Various Green Seaweeds
MyoungLae Cho, Il‐Jun Kang, Moo‐Ho Won, Hyi-Seung Lee, SangGuan You
SJR Q3Journal of Medicinal Food

The antioxidant activities of the ethanol (EtOH) extracts from the green seaweeds Enteromorpha compressa, Capsosiphon fulvescens, Chaetomorpha moniligera, and Ulva pertusa, as well as their solvent-partitioned fractions, were investigated, and their antioxidant activities were correlated with total phenolic and flavonoid contents. The EtOH extracts and their solvent-partitioned fractions showed 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl (OH•) radical scavenging activities with strong redu

Aquatic ScienceAgricultural and Biological Sciences
5
논문|인용수 79·2010
Inhibitory effects of fucan sulfates on enzymatic hydrolysis of starch
MyoungLae Cho, Jung H. Han, SangGuan You
SJR Q1LWTOA

The effect of fucoidan and its oversulfated derivative on starch digestibility was investigated by determining the enzymatic reaction kinetics and their inhibitory activity against α-amylase and amyloglucosidase. After the α-amylase hydrolysis, the produced reducing sugars of the buckwheat starch (BW, 2.0–3.0 g/100 mL) and those of the blends of BW with low levels of native fucoidan (NF, 0.5–1.0 g/100 mL) and oversulfated fucoidan (OSF, 0.5–1.0 g/100 mL) were in the range of 440–450 mg/g starch.

Aquatic ScienceAgricultural and Biological Sciences
6
논문|인용수 71·2018
Selective inhibition of monoamine oxidase A by hispidol
Seung Cheol Baek, Hyun-Woo Lee, Hyung Won Ryu, Myung-Gyun Kang, Daeui Park, Soo Hyun Kim, MyoungLae Cho, Sei‐Ryang Oh, Hoon Kim
SJR Q2Bioorganic & Medicinal Chemistry LettersOA
PharmacologyMedicine
7
논문|인용수 68·2013
Molecular characteristics and biological activities of anionic macromolecules from Codium fragile
Mehdi Tabarsa, Supatra Karnjanapratum, MyoungLae Cho, Jin‐Kyung Kim, SangGuan You
SJR Q1International Journal of Biological Macromolecules
Organic ChemistryChemistry
8
논문|인용수 63·2019
Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds
Jae Pil Lee, Myung-Gyun Kang, Joon Yeop Lee, Jong‐Min Oh, Seung Cheol Baek, Hyun Hee Leem, Daeui Park, MyoungLae Cho, Hoon Kim
SJR Q1Bioorganic Chemistry
PharmacologyMedicine
9
논문|인용수 54·2014
Molecular characterization and immunomodulatory activity of sulfated fucans from Agarum cribrosum
MyoungLae Cho, Dong‐Jin Lee, Jin‐Kyung Kim, SangGuan You
SJR Q1Carbohydrate Polymers
Aquatic ScienceAgricultural and Biological Sciences
10
논문|인용수 41·2020
Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis
Geum Seok Jeong, Myung-Gyun Kang, Joon Yeop Lee, Sang Ryong Lee, Daeui Park, MyoungLae Cho, Hoon Kim
SJR Q1MoleculesOA

Eight compounds were isolated from the roots of Glycyrrhiza uralensis and tested for cholinesterase (ChE) and monoamine oxidase (MAO) inhibitory activities. The coumarin glycyrol (GC) effectively inhibited butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) with IC50 values of 7.22 and 14.77 µM, respectively, and also moderately inhibited MAO-B (29.48 µM). Six of the other seven compounds only weakly inhibited AChE and BChE, whereas liquiritin apioside moderately inhibited AChE (IC50 =

PharmacologyPharmacology, Toxicology and Pharmaceutics
11
논문|인용수 40·2009
Steady and Dynamic Shear Rheology of Fucoidan‐Buckwheat Starch Mixtures
MyoungLae Cho, Won‐Seok Choi, SangGuan You
SJR Q2Starch - Stärke

Abstract Rheological properties of fucoidan (F) and buckwheat starch (B) mixtures (3% or 6%) at different blending ratios of fucoidans (0, 0.1, 0.2, 0.5 and 1.0%) were investigated in steady and dynamic shear. Steady shear viscosity measurement revealed that aqueous pastes of the BF blends (3%, w/v) had a pseudoplastic and shear‐thinning behavior with flow behavior index ( n ) values of 0.61–0.68. The substitution of starch with fucoidan polymers significantly lowered the apparent viscosities co

Aquatic ScienceAgricultural and Biological Sciences
12
논문|인용수 37·2018
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid
Seung Cheol Baek, Hyung Won Ryu, Myung-Gyun Kang, Hanna Lee, Daeui Park, MyoungLae Cho, Sei‐Ryang Oh, Hoon Kim
SJR Q2Bioorganic & Medicinal Chemistry LettersOA
Organic ChemistryChemistry
13
논문|인용수 20·2016
Influence of extraction conditions on antioxidant activities and catechin content from bark of Ulmus pumila L.
MyoungLae Cho, Seok-Beom Ko, Jae‐Min Kim, Ok‐Hwan Lee, Dae-Won Lee, Jong‐Yea Kim, Jong‐Yea Kim, Jong‐Yea Kim
SJR Q2Applied Biological ChemistryOA

This study investigated the influence of extraction conditions on antioxidant activities and catechin content from bark of Ulmus pumila. The U. pumila was extracted using various concentrations of ethanol (30, 50, 80, and 99 %) and different extraction times (1, 2, and 3 h) at 60 °C. The ethanol extracts were evaluated for their antioxidant activities [1,1-diphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activities and reducing power], total p

BiochemistryMedicine
14
논문|인용수 19·2012
Radical Scavenging Activity of Ethanol Extracts and Solvent Partitioned Fractions from Various Red Seaweeds
MyoungLae Cho, Dong‐Jin Lee, SangGuan You
SJR Q4Ocean and Polar Research

The EtOH extracts of red seaweeds (Symphyocladia latiuscula, Chondrus ocellatus and Carpopeltis affinis) and solvent partitioned fractions were investigated for their 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 1,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effects and the total phenolic contents were correlated with ABTS and DPPH radical scavenging activities. The EtOH extracts and their solvent partitioned fractions exhibited strong ABTS and DPPH radical scaveng

Aquatic ScienceAgricultural and Biological Sciences
15
논문|인용수 18·2020
Preparation and characterization of folic acid conjugated sulfated polysaccharides on NK cell activation and cellular uptake in HeLa cells
Changsheng Li, Subramanian Palanisamy, Natchanok Talapphet, MyoungLae Cho, SangGuan You
SJR Q1Carbohydrate Polymers
ImmunologyImmunology and Microbiology

대표 연구 분야

Aquatic ScienceFood ScienceMolecular BiologyPharmacologyOrganic ChemistryPlant Science

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