김명수 교수

Pediatric liver transplantation is the standard of care for treatment of liver failure in children. The aim of this study was to identify the characteristics of pediatric liver transplantation in centers located in Korea and determine factors that influence outcomes. This retrospective study was performed using data from between 1988 and 2010 and included all recipients 18 yr old and younger who underwent pediatric liver transplantation in Korea during that period. Our data sources were hospital

Background/Aims: This study aimed to investigate whether everolimus (EVR) affects long-term survival after liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). Methods: The data from 303 consecutive patients with HCC who had undergone LT from January 2012 to July 2018 were retrospectively reviewed. The patients were divided into two groups: 1) patients treated with EVR in combination with calcineurin inhibitors (CNIs) (EVR group; n=114) and 2) patients treated with CNI-bas

Locally advanced hepatocellular carcinoma (HCC) with portal vein thrombosis carries a 1-year survival rate <10%. Localized concurrent chemoradiotherapy (CCRT), followed by hepatic arterial infusion chemotherapy (HAIC), was recently introduced in this setting. Here, we report our early experience with living donor liver transplantation (LDLT) in such patients after successful down-staging of HCC through CCRT and HAIC. Between December 2011 and September 2012, eight patients with locally advancedH

Multiple antibiotic reisistance threatens successful treatment of Acinetobacter baumannii infections worldwide. Increasing interest in the well-known activity of sulbactam against the genus Acinetobacter has been aroused. The purpose of this study was to compare the outcomes for patients with Acinetobacter bacteremia treated with cefoperazone/sulbactam versus imipenem/cilastatin. Forty-seven patients with Acinetobacter baumannii bacteremia were analyzed through a retrospective review of their me

Background: In the past, ABO incompatibility was an absolute contraindication for solid organ transplantation. However, multiple recent trials have suggested strategies for overcoming the reactions between graft antigens and recipient antibodies that cause graft rejection. In this study, we determined the usefulness of plasma exchange (PE) for removing anti-A/B antibodies that cause hyperacute/acute humoral graft rejection in patients undergoing ABO-incompatible kidney transplantation. Methods:

For a more useful and objective allocation system, we considered the Model for End-stage Liver Disease (MELD) system as an alternative to the Child-Turcotte-Pugh (CTP) score and status system in Korea. Development of basic assessment measures based on the Korean health service environment is the objective of this study. The data collected from a series of liver transplant candidates (n=2,702, 2009∼2012) were used as raw data for statistical analysis for this study. Using MELD score cut-points at

Rapamycin, a macrocyclic lactone, is effective in reducing the incidence of acute rejection after renal transplantation. The inhibitory effects of rapamycin on lymphocyte proliferation and the molecular mechanisms that were involved have been described. However, its effects on glomerular mesangial cells have not been clearly understood, and here, we examined the effect of rapamycin on platelet-derived growth factor (PDGF)- induced extracellular matrix synthesis as well as cell proliferation in m

Background: Prophylaxis for hepatitis B virus (HBV) recurrence is essential after liver transplantation (LT) in HBV-associated recipients. We conducted real-world analysis of HBV prophylaxis after LT in the Korean population. Methods: Korean Organ Transplantation Registry (KOTRY) database and additionally collected data (n = 326) were analyzed with special reference to types of HBV prophylaxis. Results: The study cohort comprised 267 cases of living-donor LT and 59 cases of deceased-donor LT. He

Purpose: Preformed circulating donor-specific antibodies (DSAs) immunologically challenge vascular endothelium and the bile duct. However, the liver is an immune-tolerant organ and can avoid immunological challenges. This study was undertaken to analyze the effects of DSAs after adult living donor liver transplantation (LDLT). Methods: We retrospectively reviewed 219 LDLT patients’ records treated at our center. Results: Of the 219 patients, 32 (14.6%) were DSA (+) and 187 (85.4%) were DSA (–).

In development of modern electric fields, the growth of kinds of electronic devices has made the supply and research on heat dissipating films become important. To synthesize heat dissipation films with high thermal resistance for possible use in electronics applications, carbon black is doped into polyimide to increase the dissipating rate of films, at loadings of 50, 100, and 150 wt%. The resulting films display excellent thermal properties; the thermal conductivity of the film with 150 wt% ca

Peritubular capillary (PTC) C4d staining represents a marker for acute humoral rejection, however, the impact of positive staining on chronic allograft dysfunction has received little attention. Ninety-three renal allograft biopsies from 93 patients were selected from a total of 174 renal allograft biopsies, which were obtained 6 months or more after transplantation (median: 89 months). Fresh frozen renal tissue was stained with monoclonal antibody against C4d. Sixteen of 93 biopsies showed C4d

The first deceased donor organ (kidney) recovery and transplantation was performed in 1979. Since February 2000, deceased donor organ recovery and allocation have been performed exclusively by the direction of the Korean Network for Organ Sharing (KONOS), the governmental authority for organ transplantation in Korea. Herein, we review the annual incidence of deceased donor occurrence, transplantation statistics, and organ allocation status in the era of KONOS, and discuss about future directions

콕시디오이데스 진균증은 미국 남서부 지역의 풍토병으로 알려져 있고 우리나라는 유행지역이 아니기 때문에 진단에 혼선 및 지연을 초래할 수 있다. 그러나 해외여행자의 증가와 함께 다른 지역에서의 발병 사례가 증가하고 있으므로 임상양상과 진단이 맞지 않는 경우 환자의 유행지역의 여행력 여부에 대한 문진이 필수적이라 하겠다. 본 저자들은 콕시디오이데스 진균증의 토착지역인 미국 LA지역을 방문한 후 발생한 골반과 척추부위를 침범한 콕시디오이데스 진균증 1예를 경험하고 항진균제 사용과 함께 수술적 치료를 병행하여 치료하여 이를 보고하는 바이다.

Purpose: Highly sensitized patients with a high level of panel reactive antibody (PRA) experience more episodes of antibody-mediated rejection (AMR) and poorer graft survival than non-sensitized patients. Rituximab is a well-known monoclonal anti-CD20 antibody that causes the depletion of B lymphocytes. The aim of this study was to compare a rituximab-administered and a non-administered group of highly sensitized recipients. Methods: Forty-three kidney recipients with a PRA level of ≥50% were in