최상은 교수

The prevalence and mortality of asthma as well as SA increases along with the burden of health care uses/costs. More active interventions, including changes in health care policies, are needed to reduce the prevalence and mortality of asthma, especially SA.

BACKGROUND: The discriminatory ability of multi-attribute utility (MAU) measures compared to condition-specific measures (CSM) in assessing health-related quality of life (HRQoL) among patients with chronic obstructive pulmonary disease (COPD) is an unsettled issue. This study investigated the quality of life of patients with COPD with three different HRQoL instruments and examined whether they could differentiate between adjacent severity groups in a statistically and clinically meaningful mann

BACKGROUND: Iron-deficiency anemia (IDA) is prevalent in patients with advanced chronic heart failure (CHF). It affects the patients' overall physical condition and is suggested as a strong outcome predictor in CHF. Recent clinical trials suggested that intravenous iron supplementation improves CHF functional status and quality of life. The aim of this study was to assess the cost-effectiveness of ferric carboxymaltose(FCM) in CHF patients with IDA. METHODS: Ferric carboxymaltose, an intravenous

Donepezil is used for the palliative treatment of mild to moderate dementia of the Alzheimer’s disease. Donepezil crystallized as four solvent-free polymorphs including forms I, II, C, and F which differ in molecular conformations and packing. Conformational difference comes from the torsion of the 2, 3-dihydroinden-1-one moiety and methyl-benzyl ring with respect to piperidyl ring. Similar melting temperatures and heats of fusion were observed for four solvent-free polymorphic forms and made po

The QIV and ATIV strategies were considered more cost-effective in comparison to the TIV for vaccination strategies implemented for the elderly. However, owing to a lack of data on the effectiveness of ATIV among the elderly, a large-scale effectiveness study is required.

BACKGROUND: There is no research on mapping algorithms between EQ-5D and COPD assessment test (CAT) in Korea. The purpose of this study was to develop mapping algorithms that predict EQ-5D-3 L utility from the CAT in patients with COPD. METHODS: Survey data of 300 COPD patients were collected from three tertiary teaching hospitals in Korea. To predict EQ-5D-3 L utility from the CAT, various models were assessed. Models were developed using randomly split training samples. Subsequently, the model

본 연구는 최근 4개년(2010-2013) 동안의 국민건강영양조사 자료를 이용하여 흡연이 유발하는 대표적인 질병인 심혈관질환과 폐질환의 유병률을 확인하고 흡연이 해당 질병에 미치는 영향을 연령, 성별, 학력, 혼인여부 등을 고려하여 추정하였다. 심혈관질환과 폐질환 모두 40세 미만 연령대에선 거의 나타나지 않았다. 40세 이상 성인의 심혈관질환 유병률은 남성이 3.6%, 여성이 3.2%로 남녀간 차이가 크지 않았으나 폐질환의 경우 남성 유병률이 1.1%, 여성이 0.4%로 남성이 여성보다 2배 이상 높게 나타났다. 로지스틱 회귀분석을 이용해 흡연이 심혈관질환과 폐질환에 미치는 영향을 추정한 결과 여성의 경우 환자 표본수의 부족으로 유의한 영향을 찾을 수 없었고, 남성의 경우 흡연자는 비흡연자보다 심혈관질환의 위험이 1.9배, 폐질환의 위험이 2.9배 정도로 높아짐을 확인하였다. 또한 남녀 모두에서 연령의 증가는 심혈관질환의 상승요인인 것을 확인하였다. 과거흡연자가 현재흡연자보다 질병

Vortioxetine dominated venlafaxine XR in South Korea and is a relevant treatment option for MDD patients initiating or switching therapy.

Treating advanced adenocarcinoma based on EGFR mutation status has beneficial effects and saves the cost compared to no testing strategy in South Korea. However, the cost-effectiveness of EGFR mutation testing was heavily affected by the cost-effectiveness of the targeted therapy.

오리지널 의약품과 같은 효능을 가지면서 값이 싼 제네릭 의약품을 처방, 사용하는 것은 소비자의 약제비 부담을 줄여주고, 국가의 건강보험지출을 합리적으로 하는 수단이 될 수 있다. 제네릭 의약품에 대한 연구가 중요함에도 불구하고, 오리지널과 제네릭을 분류할 수 있는 객관적인 기준과 자료가 없었기 때문에, 우리나라에서는 이에 대한 연구가 활발히 이루어지지 않았다. 본 연구는 청구금액 상위 10대 성분에 한정시켜, 오리지널과 제네릭 의약품의 분류를 위한 객관적 기준을 마련코자 하였으며, 제네릭 의약품의 가격과 사용량 수준을 파악하였다. 연구 결과, 단가가 높은 의약품이 오리지널 의약품이 아닌 경우가 많았으며, 제네릭 의약품의 가격 역전 현상이 빈번하게 발생하는 것을 알 수 있었다. 제네릭 의약품들간의 가격 편차가 크고, 고가 제네릭 의약품의 사용량이 많은 것으로 나타났으며, 제네릭 의약품과 오리지널의약품간의 가격 차이가 작아질수록 점유율이 커지는 것으로 나타났다. 유럽 11개국에서 제

The high disease burden of influenza in elderly and chronically ill adults may be due to the suboptimal effectiveness and mismatch of the conventional trivalent influenza vaccine (TIV). This study evaluated the cost-effectiveness of quadrivalent (QIV), adjuvanted trivalent (ATIV), and high-dose quadrivalent (HD-QIV) vaccines versus TIV used under the current Korean National Immunization Program (NIP) in older adults aged ≥65 years. We also evaluated the cost-effectiveness of programs for at-risk

Although the BNR system design assumes no sludge settling problems in the final settling tank, the fluctuation of daily loading and up to 40% of anaerobiosis in the BNR system would be considerable factors in determining the sludge settleability. The sludge volume index (SVI) is a classical parameter to examine the sludge settleability but it has a limited value to evaluate the overall settling characteristics. The extracellular polymer (ECP) content in sludge has long been considered as an indi