이상민 교수
Sang Min Lee
서울대학교 내과 · 의학
연구실 소개
이상민 교수의 연구실은 주로 척추측만증의 수술적 치료 전략과 복합적 척추변형의 분류 기준을 제안하며 척추외과 분야의 임상적 기준을 정립하고 있습니다. 또한 어류의 영양 요구량과 단백질 섭취 최적화에 관한 생리학적 연구를 통해 수산업의 지속가능한 발전을 모색하고 있습니다. 최근에는 이식 후 합병증인 급성 섬유성 및 조직형 폐렴(AFOP)과 같은 희귀 폐질환의 병리학적 특성 규명에도 기여하고 있습니다. 특히, 천연물인 꿀벌독의 신경보호 작용과 신경전달물질 글루타메이트와의 상호작용에 대한 기초 연구를 통해 신경퇴행성질환 예방 전략을 모색하고 있습니다.
연구 현황
연구 성과 추이
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주요 논문
15Idiopathic thoracic scoliosis with a proximal thoracic curve of more than 25 degrees and level or elevated left shoulder should be considered a double thoracic curve pattern and should be treated by fusing both the proximal and the distal curves when using segmental instrumentation.
The optimum dietary protein level for the growth of young Japanese flounder was investigated. Three replicate groups of fish (average weight 22.7 g) were fed six isocaloric diets containing various protein levels from 40% to 65% for 9 weeks. Casein and white fishmeal were used as the dietary protein sources. Weight gain and feed efficiency of fish fed diets with 45% and 50% protein levels were significantly higher than the other groups (P < 0.05). Protein efficiency ratio of fish fed diets with
The effect of surgical therapy for IBD on female infertility is uncertain. It is also uncertain if there are any differences in infertility among those undergoing open versus laparoscopic procedures. Previous surgery was associated with higher risk of miscarriage, use of ART, Caesarean section delivery, and giving birth to a low birth weight infant, but was not associated with risk of stillbirth, preterm delivery, or delivery of a small for gestational age infant. These findings are based on ver
A 60-year-old man presented with cough, sputum, and dyspnea. He had a history of acute myeloid leukemia and hematopoietic stem cell transplantation with chronic renal failure. Chest CT scans showed miliary nodules and patchy consolidations. Histological examination revealed numerous fibrin balls within the alveoli and thickening of the alveolar septum, both of which are typical pathological features of acute fibrinous and organizing pneumonia (AFOP). We report the first case of AFOP following al
Bee venom (BV), which is extracted from honeybees, is used in traditional Korean medical therapy. Several groups have demonstrated the anti-inflammatory effects of BV in osteoarthritis both in vivo and in vitro. Glutamate is the predominant excitatory neurotransmitter in the central nervous system (CNS). Changes in glutamate release and uptake due to alterations in the activity of glutamate transporters have been reported in many neurodegenerative diseases, including Parkinson's disease, Alzheim
The objective of this study was to evaluate skills in handling inhalers and factors associated with these skills among patients with asthma who had undergone treatment at special asthma and allergy clinics in Korea. Methods: We enrolled 78 subjects who used Turbuhaler and 145 who used Diskus for asthma control at special clinics in 10 university hospitals and visually assessed their skills in handling these inhalers. We also evaluated skills in 137 subjects who had used pressurized metered-dose
BACKGROUND AND OBJECTIVES: Ten to twenty percent of children with Kawasaki disease (KD) do not respond to initial intravenous immunoglobulin (IVIG) treatment. If untreated, approximately 15% to 25% of KD patients have complications. The aim of this study was to find useful predictors of responsiveness to initial IVIG treatment in KD. SUBJECTS AND METHODS: We retrospectively reviewed medical records of 91 children diagnosed with KD at Myong Ji Hospital from March 2012 to April 2014. Before and af
Clinical trials of intralymphatic immunotherapy (ILIT) have been performed to overcome the limitations of long-term therapy and the local or systemic hypersensitivity reactions in conventional allergen-specific immunotherapy, including subcutaneous or sublingual immunotherapy. Additionally, several animal studies of ILIT have been conducted in the form of translational or veterinary research. We conducted a literature review to examine the treatment efficacy and adverse effects of ILIT.
PURPOSE: There are controversies around the role of the posterior cruciate ligament and the effect of design modifications for high flexion in total knee arthroplasty (TKA). So, we compared the clinical outcomes of the cruciate retaining (CR), posterior stabilized (PS), and high flexion posterior stabilized (F-PS) designs in TKA with identical femoral geometry. MATERIALS AND METHODS: One hundred seventy nine knees with 3 different types of prostheses after a minimum 5-year follow-up were enrolle
Two feeding experiments were conducted to investigate the effects of dietary paprika (DP) and lipid (DL) levels on growth performance and skin pigmentation of pale chub, Zacco platypus. Six diets (designated as P 0 L 8 , P 0 L 17 , P 8 L 8 , P 8 L 17 , P 16 L 8 and P 16 L 17 ) were formulated to contain 0%, 8% and 16% paprika with 8% and 17% lipid, respectively. For the growth experiment (Exp I), three replicate groups of fish (average weight 2.60.2 g) were fed one of the six experimental diets
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