한상웅 교수

BACKGROUND: Renin-angiotensin system (RAS) blockades, angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are well accepted for the cardiorenal-protective benefits added to antihypertensive effects in chronic kidney diseases (CKD), but associated with an increased risk of hyperkalaemia. However, few studies have investigated the effect of RAS blockades on serum potassium in dialysis patients. METHODS: Hyperkalaemia associated with RAS blockades by ACEI an

<b><i>Background: </i></b>Chronic kidney disease (CKD) patients are prone to both hypo- and hypernatremia. Little has been published on the epidemiology of hypo- and hypernatremia in ambulatory patients with non-dialysis CKD. <b><i>Methods:</i></b> Data collected in two contemporaneous CKD cohort studies, the Renal Research Institute (RRI)-CKD study (n = 834) and the Study of Treatment of Renal Insufficiency: Data and Evaluation (STRIDE) (n = 1,348

TLV is effective in correcting hyponatremia and well-tolerated in Korean patients with SIADH. However, those with low body weight, low BMI or severe hyponatremia, could be vulnerable to overcorrection with the initial dose of 15 mg TLV.

Purpose . To investigate the effect of hemodialysis (HD) on the anterior chamber angle by anterior segment optical coherence tomography (ASOCT) and other ophthalmologic parameters in patients with end-stage kidney disease (ESKD). Methods . A prospective observational study was performed on 20 patients who underwent HD for ESKD. Anterior chamber angle images were obtained by 16 mm line scan of ASOCT. The angle opening distance (AOD) and the trabecular-iris space area (TISA) were determined using

Background: The aim of this multicenter study was to evaluate the safety and efficacy of tolvaptan (TLV) in Korean patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Methods: Of 51 enrolled patients with SIADH, 39 patients (16 female patients, aged 70.8 ± 11.3 years) were included in an intention to treat analysis. All patients received 15 mg/day as the initial dose, and the dose was then increased up to 60 mg/day (as needed) until day 4. Results: Serum sodium

AIM To study the effects of puerarin on spinal cord injury resulting from ischemia and reperfusion. METHODS Twenty male New Zealands white rabbits were randomly divided into two groups: ischemia group (Group A, n =10) and puerarin group (Group B, n =10). The spinal cord ischemia rabbit model was made by occluding infrarenal abdominal aorta for 20 min. In Group B, puerarin 30 mg·kg -1 was administered intravenously 10 min before clamping. In Group A, 9 g·L -1 saline was used as Group B. The produ

Potassium balance and serum potassium level are maintained until very late in chronic kidney disease (CKD), mainly because of an increase in renal and colonic excretion. Hyperkalemia may develop earlier in the course of CKD in patients with hyporeninemic hypoaldosteronism. Hyperkalemia in CKD patients may occur in association with excess dietary potassium intake, constipation or prolonged fasting. It may also be seen with the use of potassium-sparing diuretics, angiotensin converting enzyme inhi

So far, less than 10% of hemodialysis (HD) facilities in Korea have adopted a kind of central delivery system (CDS) for dialysates, the so-called Korean central concentrate delivery system (CCDS). In our CCDS, all concentrate solutions of the acid and bicarbonate dry powder mixed with the treated reverse osmosis (RO) water in the mixing tank and stored in the holding tank are centrally delivered to individual HD machines via two streams along with a one further stream for dilution RO water. This

Abstract Background and Aims Hypoalbuminemia is a clinical indicator of vascular endothelial dysfunction. However, the genetic association of hypoalbuminemia with hypertension has not yet been clarified. We investigated whether genetic variation(s) associated with decreased serum albumin level is deeply related with increased risk of hypertension. Method Mild hypoalbuminemia was defined as a serum albumin concentration of less than 4.0 g/dL. We performed GWAS-based instrumental variable analysis

For a fixed jacket type offshore structure directly supported by the seabed, the structural behavior of offshore structure depends on the soil properties. Soil properties affect on the stiffness of the piles and the boundary condition in the structural analysis. The structural analysis is performed using PSI (Pile-Soil Interaction) suggested in the code and design rule. PSI analysis of the jacket structure is carried out after various soil types are selected according to the soil properties like

Ovarian specimens from 159 different patients were analyzed for estrogen and progesterone receptor (ER and PR) content with the Dextran-coated Charcoal method. The results indicated that the contents of ER and PR in malignant ovarian tumors were not correlated with the menstrual cycle of the patient, clinical stage and differentiation of the tumor. Among malignant ovarian tumors, the mean ER and PR concentrations in sex-cord stromal tumors and endometrioid carcinomas were higher than those in ot