신상훈 교수

AIMS: High calcium (Ca), phosphate (P), and Ca-P product (CPP) are associated with cardiovascular disease in patients with chronic kidney disease. Whether this relationship persists in individuals with normal kidney function is not yet elucidated. We explored the relationship of serum Ca, P, and CPP to coronary atherosclerosis assessed by cardiac computed tomography angiography (cCTA) in participants with normal kidney function. METHODS AND RESULTS: This study included 7553 participants (52 ± 10

O-linked N-acetylglucosamine transferase (OGT) catalyzes O-GlcNAc addition to numerous cellular proteins including transcription and nuclear pore complexes and plays a key role in cellular signaling. One differentially spliced isoform of OGT is normally targeted to mitochondria (mOGT) but is quite cytotoxic when expressed in cells compared with the ncOGT isoform. To understand the basis of this selective cytotoxicity, we constructed a fully functional ecdysone-inducible GFP-OGT. Elevated GFP-OGT

PURPOSE: Primary central nervous system lymphoma (PCNSL) is an uncommon brain tumor accounting for 2%-5% of all primary brain tumors. Few population-based analyses of survival for patients with PCNSL have been conducted, particularly in Asian countries. MATERIALS AND METHODS: Using the Korea National Cancer Incidence Database, 1,062 cases of PCNSL newly diagnosed from 1999 to 2009 were analyzed. The crude rate, age-standardized rate (ASR), and annual percent change were calculated. To estimate t

High sFlt-1 level is predictive of carotid IMT progression in hypertensive patients. Low HDL-C level was also associated with IMT change. These observations support a high sFlt-1 level being indicative of progression of atherosclerosis.

This study was performed to assess the efficacy of beraprost sodium (BPS) in painful diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. In this randomized clinical trial, 99 T2DM patients (41% male, age 60 ± 6 years) with DPN but without evidence of peripheral artery disease were randomized to receive either BPS (40 µg, tid) or placebo for 8 weeks. The primary end point was the improvement of the total symptom score (TSS), temperature rebound (TR) and nadir to peak

ABSTRACT This paper analyzes the effects of mode selection, scaling, and orthogonalization on dynamic analysis of flexible mechanical systems. The effects of mode selection are investigated by combining attachment modes and constraint modes with vibration normal modes to represent elastic deformations of flexible components. Four sets of input data that depend on the options for mode scaling and orthogonalization are generated. The dynamic response and computer simulation times for each set are

Subintimal angioplasty is an effective method for the treatment of long superficial femoral artery (SFA) occlusions. One of the major limiting factors for the success of this procedure is the failure to re-enter the true lumen. The recently introduced luminal re-entry devices provide a high technical success rate, but failures can occur. In such cases, a retrograde popliteal approach can serve as a potential backup option. However, the need to reposition the patient remains a drawback. Here, we

사상의학은 체질에 따라 치료하는 방법을 달리하므로, 체질진단의 객관화가 절실히 요구되고 있다. 본 연구는 맥파를 이용하여 사상체질을 객관적으로 진단함에 있어서, 정확도가 높으면서 실용적인 체질분류 방법을 탐색하는 것이 목적이다. 한방병원에 건강검진을 목적으로 내원한 2848명의 피험자를 대상으로 전문의가 진단한 체질, 체질량지수, 혈압, 맥파 자료를 입수하였다. 자료의 선별과정을 통하여 최종적으로 1635명의 자료를 분석에 사용하였다. 판별분석, 회귀분석, 의사결정나무, 신경망으로 체질을 예측하고 전문의가 진단한 결과와 비교하여 분류방법의 정확도를 비교하였다. 판별분석은 체질별로 공분산 행렬이 동일해야 한다는 가정을 만족시키기 어려웠으며, 체질량지수를 고려하지 않은 의사결정나무와 신경망 분석의 결과는 분석표본의 변동에 민감했다. 체질분류에 결정적인 영향을 미치는 변수인 체질량지수가 고려된 로지스틱 회귀분석 또는 의사결정나무 방법이 체질분류 방법으로 추천할 만하다. The purpos

Objectives The gait disturbance in spastic paraplegic patients lowers the gait speed, increases fall risk and eventually lower the quality of life. This study aims to investigate the effect of electrical twitch obtaining intramuscular stimulation (ETOIMS) on spastic paraplegic patients’ gait speed and pattern. Methods A prospective short-term cohort study was designed in the outpatient clinic of the department of rehabilitation in a tertiary hospital. Patients with spastic paraplegia (N=5) were

Triflusal was more effective and demonstrated a more consistent impact on the improvement of symptoms and blood flow in patients with PVD than aspirin.

Today international trade through maritime transportation is significantly increasing. Due to this increase, shipping companies are faced with problems concerning the repositioning of empty containers from import dominant ports. The liner shipping service network has been provided to transport containers which load customers’ freights. Container ships are moved on the liner shipping service network by observing the predetermined route and transportation time. This research deals with the empty c

Abstract Background/Introduction Coronary computed tomography angiography (CCTA) has developed rapidly, enabling the evaluation of coronary stenosis as well as plaque characteristics. However, it is not clear whether the adverse plaque characteristics found in CCTA are really vulnerable plaques. Near-infrared spectroscopy (NIRS) is able to quantify cholesterol within coronary arteries by the lipid core burden index (LCBI). Purpose The purpose of this study was to determine whether positive remod