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BACKGROUND AND AIMS: Living liver donation with high model for end-stage liver disease (MELD) score was discouraged despite organ shortage. This study aimed to compare graft survival between living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) recipients with extremely high-MELD (score of ≥35). METHODS: Between 2008 and 2018, 359 patients who underwent liver transplantation with a MELD score ≥35 were enrolled. We compared graft survival between LDLT and DDLT

FIB-4 is identified as a statistically significant predictor of HCC prognosis after curative LR even in HBV dominant populations.

Introduction: Laparoscopic donor hepatectomy (LDH) has many advantages over open donor hepatectomy. However, previous abdominal surgical history can be considered to cause difficulties in laparoscopic surgery. Few studies have evaluated the impact of previous abdominal surgery (PAS) on LDH. Therefore, we studied the effect of PAS on LDH. Method: This study is a retrospective study conducted at a single center. We reviewed the data of 361 patients who underwent LDH at Samsung Medical Center from

Purpose: For patients with short bowel syndrome, surgery can play an important role in the management of intestinal failure (IF). Serial transverse enteroplasty (STEP) has become a popular choice of bowel lengthening among surgeons for its safety and effectiveness in improving enteral autonomy. In this study, we report 5 cases of STEP procedure on 4 patients. Materials and Methods: In the Intestinal Rehabilitation Team at Samsung Medical Center, all patients were managed by a multidisciplinary t

Activin regulates inflammation, cell proliferation, immune response, wound repair, and endocrine function. In this study, we investigated the effect of activin on inflammatory genes in THP-1 cells and the involvement of NF-κB, AKT, and mitogen-activated protein kinase (MAPK) signaling. Cell viability was determined using a colorimetric assay with the MTS/PES solution. The mRNA levels were analyzed using reverse transcription-quantitative polymerase chain reaction. The expression of NF-κB, AKT, a

While immunosuppressants have improved organ transplantation outcomes, immune-mediated rejection remains a major challenge. Calcineurin inhibitors such as tacrolimus (FK-506) prevent acute rejection but cause nephrotoxicity, hypertension, and other adverse effects that contribute to transplant vasculopathy. This study evaluated the effects of soluble programmed death-ligand 1 (PD-L1) alone and combined with FK-506 on graft survival and immune modulation in a heterotopic heart transplantation mod

Background: Living liver donation with high model for end-stage liver disease (MELD) score was discouraged until recently despite organ shortage.This study aimed to compare graft survival between living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) recipients with extremely high MELD (score of ≥ 35).Methods: Between 2008 and 2018, 359 patients who underwent liver transplantation with a MELD score ≥ 35 at the Samsung Medical Center, Republic of Korea were enro

Background: Although organ shortage was still the greatest problem in liver transplantation, living liver donation with high model for end-stage liver disease (MELD) score was discouraged until recently. The purpose of this study was to compare graft survival between living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) groups in extremely high MELD recipient defined as score 35 and to evaluate risk factors affecting graft survival. Methods: Between 2008 and 2

PURPOSE: This study evaluated the role of donor kidney ultrasonography (US) for predicting functional kidney volume and identifying ideal kidney grafts in deceased donor kidney transplantation. METHODS: In total, 272 patients who underwent deceased donor kidney transplantation from 2000 to 2020 at Samsung Medical Center were enrolled. Donor kidney information (i.e., right or left) was provided to the radiologist who performed US image re-analysis. To binarize each kidney's ultrasound parameters,

Donations from deceased donors have been increasing since the introduction of expanded criteria for donor kidney selection. Several studies have shown that patients receiving deceased donor kidneys using these expanded criteria have improved survival compared to those remaining on the waiting list during hemodialysis. It is important, however, to consider that some of the kidneys classed as usable under the expanded criteria may in fact be unacceptable. To address this concern, preoperative biop

We try to evaluate the effect of functional kidney volume measured by donor kidney ultrasound, alone or in combination with other donor factors and see if those parameters could be a model for deciding acceptable kidney grafts in deceased donor kidney transplantation (KT). Methods: From 2000 to 2020 who underwent deceased donor KT and those donors were recruited only at the Samsung Medical Center and total 273 patients were enrolled after adjusting exclusion criteria. Estimated glomerular filtra

Background: Although many staging systems and liver reserve models were not developed to predict HCC recurrence and overall survival, the few studies, which have investigated their prognostic values in predicting prognosis of HCC patients after curative hepatic resection. Among those non-invasive biomarkers, we try to evaluate the value of FIB-4 and APRI as prognostic predictors. Methods: Between 2006 and 2013, 973 patients were diagnosed with HCC and underwent hepatic resection at the Departmen

We evaluated the role of functional kidney volume using donor kidney ultrasound (US) alone or in combination with other donor factors and parameters appropriate for kidney grafts in deceased donor kidney transplantation (DDKT). A total of 273 patients who underwent deceased donor kidney transplantation from 2000 to 2020 at Samsung Medical Center were enrolled after adjusting for exclusion criteria. Estimated GFR was used to evaluate kidney function. An experienced genitourinary radiologist (*BLI

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Background: Using kidneys from expanded criteria donors (ECD) has been increased due to the shortage of donor organs but seemed to have poorer prognosis. The aim of this study was to evaluate the safety and efficacy of rabbit anti-thymocyte globulin (rATG) induction in kidney transplantation (KT) from ECD compared to anti IL-2 receptor antibody (basiliximab). Methods: We retrospectively analyzed 182 patients who underwent KT from ECDs between April 2004 and December 2020. The patients were categ