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김서라 교수

Seo-Ra Kim

연세대학교 산부인과 · 의학

연구실 소개

김서라 교수의 연구실은 신경보호 및 약물의 신경독성 완화 메커니즘을 중심으로 연구를 진행하고 있습니다. 특히 간성소성산염(Rb1, Rg3)이 글루타메이트 유도 신경퇴행성 손상에서 뇌세포를 보호하는 기전을 규명하며 신경질환 예방에 기여하고자 합니다. 또한 임상적 적용이 가능한 약물 기반의 신경보호 전략 개발과 함께, 환자의 생존율 향상을 위한 치료법 최적화에도 주력하고 있습니다.

신경보호간성소성산염신경퇴행성 손상약물 기반 치료임상 적용

연구 현황

논문 수
18
총 인용 수
78
최근 5년 논문
7
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
7총합
2016
2017
2019
2021
2023
5개년 연도별 피인용 수
24총합
20162017201920212023

주요 논문

15
1
논문|인용수 36·1998
Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. J Neurosci Res 53:426-432.
YC Kim, SR Kim, GJ Markelonis, TH Oh
SJR Q2Journal of Neuroscience Research

Kim YC, Kim SR, Markelonis GJ, Oh TH (1998): Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. J Neurosci Res 53:426–432. On page 427 of the article referenced above, under the heading Assessment of Neurotoxicity in the Materials and Methods section, the formula given for the assessment of percentage cell viability was printed incorrectly. The formula is correctly stated in a footnote to Table 1 on page 429. The correct formula appears below:

Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
논문|인용수 24·2016
A New Practical Desensitization Protocol for Oxaliplatin-Induced Immediate Hypersensitivity Reactions: A Necessary and Useful Approach
Hyun Jung Park, JH Lee, SR Kim, Seung‐Hyun Kim, KH Park, CK Lee, BD Kang, Seung‐Hoon Beom, SJ Shin, Minkyu Jung, Jung‐Won Park
SJR Q3Journal of Investigational Allergology and Clinical ImmunologyOA

Many patients who experience oxaliplatin-induced IHSRs are required to stop first-line oxaliplatin-based chemotherapy or to continue without desensitization, with the associated risks. Our new desensitization protocol is practical and easy to use in clinical practice.

OncologyMedicine
3
논문|인용수 16·2008
Using 100% Oxygen does not Alter the Cardiovascular Autonomic Regulation during Non-invasively Simulated Haemorrhage in Healthy Volunteers
YK Kim, IG Jun, SR Kim, JH Hwang, Steve K. Cho, S.M. Han, GS Hwang
SJR Q3Journal of International Medical Research

We tested the effect of 100% oxygen on heart rate (HR), arterial blood pressure (ABP), cardiac output (CO), stroke volume (SV), total peripheral resistance (TPR), HR variability (HRV), systolic blood pressure variability (SBPV) and baroreflex sensitivity (BRS) in 20 healthy volunteers during simulated haemorrhage induced by -40 mmHg lower body negative pressure (LBNP). HRV in the high frequency region (HRV HF), BRS, ABP and TPR were significantly increased, SBPV in the low frequency region (SBPV

Cardiology and Cardiovascular MedicineMedicine
4
논문|인용수 2·2013
P137: Effectiveness of a hand hygiene improvement program in doctors: active monitoring and real-time feedback
SR Kim, Myung‐Haing Cho, Kim Wj, JY Song, Hee Jin Cheong
SJR Q1Antimicrobial Resistance and Infection ControlOA

Hand hygiene is the single most important intervention to combat infections in diverse health care settings. However, adherence to hand hygiene practice remains low among health care workers, especially in doctors.

Infectious DiseasesMedicine
5
논문|인용수 0·2021
Non-Structural 5A Resistance-Associated Substitutions and Interleukin28B in HCV Genotype 3b Decompensated Cirrhosis Patients with Sofosbuvir Plus Velpatasvir
Kim Sk, T. Fujii, SR Kim, Yoshiko Fujii, Hitome Kobayashi, Takanobu Hayakumo, Tomoaki Okuda, Akihito Nakai, K Yuasa, M Takami, Kim KI, Aya Ohtani
Annals of Clinical and Medical Case Reports
HepatologyMedicine
6
논문|인용수 0·2019
P71 Does mismatch repair (MMR) deficiency have prognostic significance in low-risk endometrioid endometrial cancers?
SR Kim, Annick Pina, Arianne Albert, Jessica N. McAlpine, Robert Wolber, C. Blake Gilks, Mark Carey, Janice S. Kwon
SJR Q1International Journal of Gynecological Cancer

<h3>Introduction/Background</h3> Mismatch repair deficiency (MMRd) is observed in 25–30% of all endometrial cancers. This can be detected by the absence of MMR protein staining on immunohistochemistry (IHC). Only 10% of women with MMRd have Lynch syndrome, but MMRd may still have prognostic significance. The objective of this study was to compare clinical outcomes between MMR deficient and proficient low-risk endometrioid endometrial cancers (stage IA, grade 1/2). <h3>Methodology</h3> This was a

Pathology and Forensic MedicineMedicine
7
논문|인용수 0·2012
Anthocyanin analysis of Acanthopanax fruits using HPLC-ESI tandem MS
SH Jeong, SR Kim, YP Jang
SJR Q2Planta Medica

Acanthopanax species are indigenous medicinal plant and the fruits of Acanthopanax species have been used as a remedy for “wipe out evil wind” in traditional medicine. Although there have been a few phytochemical studies on Acanthopanax fruits, no study on the comparison of anthocyanin contents and types between Acanthopanax species distributed in Korea was performed. In order to provide the phytochemical information about two major Acanthopanax species in Korea, Acanthopanax senticosus and Acan

Food ScienceAgricultural and Biological Sciences
8
논문|인용수 0·1992
Lymphokine-activated killer(LAK) Cell Activity and Phenotypic Characterization in Peripheral Lymphocytes of Patients with Cervical Cancer
SR Kim, Kyong‐Tai Kim, Seung‐Hun Cho, YY Hwang, Anna Lee, Hee Jung Moon, Jeong‐Min Kim, YJ Cho
Korean Journal of Gynecologic Oncology and ColposcopyOA
ImmunologyImmunology and Microbiology
9
논문|인용수 0·2023
Performance of improved versions of Swarna introgressed with yield enhancing genes in multi-location trials
Kousik MBVN, E. Punniakotti, G. Rekha, K. Chaitra, G. Harika, T. Dilip, Hajira Sk, Swapnil RK, Laxmi Prasanna B, Mastanbee SK, M. Anila, Ayyappa Dass M
ORYZA- An International Journal on RiceOA

Swarna (MTU7029), an Indian mega-variety of rice, is cultivated on an estimated 8Mha of land. There is a pressing need to address yield stagnation and wider adaptability to irrigated lowland and rainfed ecologies as a result of the negative consequences of climate change and population growth. The present study was aimed at improving Swarna for two yield-related traits through marker-assisted backcross breeding strategy by introgression of OsSPL14 (panicle branching) and SCM2 (stronger culm). Fo

Plant ScienceAgricultural and Biological Sciences
10
논문|인용수 0·1998
Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate‐induced neurodegeneration. J Neurosci Res 53:426‐432.
YC Kim, SR Kim, GJ Markelonis, TH Oh
SJR Q2Journal of Neuroscience ResearchOA

On page 427 of the article referenced above, under the heading Assessment of Neurotoxicity in the Materials and Methods section, the formula given for the assessment of percentage cell viability was printed incorrectly.The formula is correctly stated in a footnote to Table 1 on page 429.The correct formula appears below: 100 (OD of glutamate ginsenoside-treated OD of glutamate-treated)/(OD of control OD of glutamate-treated).

Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
book chapter|인용수 0·2010
The Correlation of Adiponectin and Kidney Function in South Korea.
SR Kim, Shoei‐Sheng Lee, Yoo Sj, Seon Mee Kim, OK Hong, MW Lee, CB Lee, Seung‐June Oh, Haur Yueh Lee, Sun Ha Jee, Seok Kyu Kang
The Endocrine Society's 92nd Annual Meeting, June 19–22, 2010 - San Diego
EpidemiologyMedicine
12
논문|인용수 0·2021
EPV063/#357 The impact of surgical approach in cases with no residual disease on hysterectomy specimen: a 4C (Canadian cervical cancer collaborative) working group study
Christa Aubrey, Gregory R. Pond, Limor Helpman, Danielle Vicus, Laurie Elit, Marie Plante, Susie Lau, Ji Young Kwon, Alon D. Altman, Karla Willows, Tomer Feigenberg, Jeanelle Sabourin
SJR Q1International Journal of Gynecological CancerOA

<h3>Objectives</h3> The adverse effect of laparoscopic/robotic surgery in cervical cancer has been established, however the exact patient population that this applies to has not been fully elucidated. Our objective was to characterize the impact of surgical approach on outcomes in cases of no residual cervical cancer on hysterectomy specimen. <h3>Methods</h3> Retrospective cohort study of cases of surgically treated cervical cancer at 10 Canadian institutions from 2007–2019. Cases with no residu

Obstetrics and GynecologyMedicine
13
논문|인용수 0·2008
EC-001 Clinical and laboratory characteristics of precocious puberty in girls
SR Kim, Chang‐Hyun Kim, Kim Sh, HD Chae, BM Kang
SJR Q1Reproductive BioMedicine Online
Pediatrics, Perinatology and Child HealthMedicine
14
논문|인용수 0·2017
Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects
Woo HI, SR Kim, Huh W, Ko JW, Lee Sy
SJR Q2DOAJ (DOAJ: Directory of Open Access Journals)OA

Hye In Woo,1 Suk Ran Kim,2 Wooseong Huh,3,4 Jae-Wook Ko,4 Soo-Youn Lee4,5 1Department of Laboratory Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea; 2Clinical Research and Development, Hanmi Pharm. Co., Ltd., Seoul, Korea; 3Department of Medicine, 4Department of Clinical Pharmacology and Therapeutics, 5Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Background: Statin

Computational Theory and MathematicsComputer Science
15
논문|인용수 0·2015
Development and optimization of a self-microemulsifying drug delivery system for atorvastatin calcium by using D-optimal mixture&nbsp;design
Yeom DW, Yong Sang Song, SR Kim, Seung Goo Lee, Kang MH, Lee S, Choi YW
SJR Q2DOAJ (DOAJ: Directory of Open Access Journals)OA

Dong Woo Yeom,1 Ye Seul Song,1 Sung Rae Kim,1 Sang Gon Lee,1 Min Hyung Kang,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, Republic of Korea Abstract: In this study, we developed and optimized a self-microemulsifying drug delivery system (SMEDDS) formulation for improving the dissolution and oral absorption of atorvastatin calcium (ATV), a poorly water-soluble drug. Solubility and emulsification tests were per

Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics

대표 연구 분야

Molecular BiologyOncologyCardiology and Cardiovascular MedicineInfectious DiseasesPediatrics, Perinatology and Child HealthHepatology

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