정소이 교수

BACKGROUND: This study was conducted to investigate the association of carcinoembryonic antigen (CEA) and glycated hemoglobin (HbA1c) in normal, prediabetic, and diabetic subjects. METHODS: A total of 2,911 participants who underwent general health checkups were enrolled and categorized into the normal, prediabetes, and diabetes groups. Demographic, anthropological, and clinical variables were investigated, and correlations with CEA were analyzed. For 28 diabetic subjects with CEA levels above t

OBJECTIVE: This study was conducted to validate the Martin method in coronary atherosclerosis in comparison with the Friedewald equation. SUBJECTS AND METHODS: A total of 299 participants with a coronary artery calcium score (CACS) ≥300 and a serum triglyceride (TG) level <400 mg/dL at Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea, were enrolled in this study. Low-density lipoprotein cholesterol (LDL-C) was directly measured with a homogeneous assay (DLDL) and

Abstract Recently, HLA class II loci, including HLA‐DPB1 , have been reported to be associated with interindividual variance in the hepatitis B (HB) vaccine response. In this study, we investigated significant single nucleotide polymorphisms (SNPs) for anti‐HBs antibody levels in 6867 healthy Koreans using a genome‐wide association study (GWAS). In GWAS, the top 20 SNPs that showed significant association with anti‐HBs levels ( P &lt; 1.0 × 10 −29 ) all resided in HLA‐DPB1 . Utilizing PCR sequen

PURPOSE OF REVIEW: β-Quantification is considered the reference measurement procedure for low-density lipoprotein cholesterol (LDL-C). However, this technique is time-consuming and thus is inappropriate for routine clinical practice. Therefore, the Friedewald equation or homogeneous assays have been widely utilized. As several pitfalls exist with these two methods, a novel method for estimating LDL-C was developed by Martin et al. RECENT FINDINGS: Martin's method uses a strata-specific median fo

「중용장구서」에서 정약용은 주희를 높이 평가하며 이는 그의 인심도심론이 주희의 주장을 어느 정도 수용한 것이라는 막연한 추측을 낳았다. 그러나 다음의 세 가지 면에서 정약용의 인심•도심론은 주희뿐 아니라 기존의 어느 설과도 구분되는 독창적인 체계를 보여준다. 첫째 정약용이 말하는 성인의 인심은 주희가 말하는 가치중립적인 생래적 욕구가 아닌 사욕을 포함한 ‘예비 악’에 가깝다. 둘째 주희의 도심은 인심의 기준이 되는 절대적이고 순선한 가치 즉 인의예지 그 자체인 것에 반해 정약용의 도심은 인심과 맞서는 도덕적 욕망으로 사욕을 저지하고 도덕행위로 이끄는 ‘동력’은 될 수 있으나 그 자체로 완전한 덕목은 아니다. 셋째 정약용의 인심과 도심은 어느 한 쪽을 ‘굳게 잡아 선택할 수 있는’ 항목이 아니다. 그들은 끊임없는 갈등相爭 속에 있으며 어느 한 쪽도 기질이나 환경에 의해 우세하게 될 수는 없다. 정약용이 이와 같이 인심과 도심을 각기 다른 방향으로 치닫는 욕구 예비 악과 예비 선으로 설

Propionibacterium acnes is a gram-positive anaerobic bacillus and a normal inhabitant of the skin. Although it is often considered a contaminant of blood cultures, it can occasionally cause serious infections, including postoperative central nervous system infections. Here, we report the case of a 70-yr-old man who developed a large cerebral abscess caused by P. acnes 13 months after neurosurgery. Immediate gram staining of the pus from his brain revealed the presence of gram-positive coccobacil

BACKGROUND: Multiple-locus variable-number tandem-repeat fingerprinting (MLVF) is based on multiplex PCR, utilizing variable number tandem repeat. Our goal was to compare the performance of MLVF in distinguishing clinical Staphylococcus aureus isolates with that of pulsed-field gel electrophoresis (PFGE), which has traditionally been the gold standard. METHODS: Sixty-three clinically significant S. aureus isolates were tested using both PFGE and MLVF. Multiplex PCR for MLVF was performed using P

Background The persistence of infection by high-risk human papillomavirus (HPV) may lead to cervical cancer. Recently, the American Society for Colposcopy and Cervical Pathology (ASCCP) announced that on-cogenic HPV screening and the PAP smear are the main methods of screening for cervical cancer. The goal of this study was to investigate the prevalence and genotyping of HPV, as well as the risk of cervical dysplasia. Methods HPV genotyping was conducted by a com-mercial chip assay. Cervical dys