박수준 교수

Abstract The first assortment of achiral pentafluorosulfanylated cyclobutanes (SF 5 ‐CBs) are now synthetically accessible through strain‐release functionalization of [1.1.0]bicyclobutanes (BCBs) using SF 5 Cl. Methods for both chloropentafluorosulfanylation and hydropentafluorosulfanylation of sulfone‐based BCBs are detailed herein, as well as proof‐of‐concept that the logic extends to tetrafluoro(aryl)sulfanylation, tetrafluoro(trifluoromethyl)sulfanylation, and three‐component pentafluorosulf

Cervical small cell neuroendocrine tumors (CSCNETs) are rare, aggressive neuroendocrine tumors (NETs). Reliable diagnostic and prognostic CSCNET markers are lacking, making diagnosis and prognosis prediction difficult, and treatment strategies limited. Here we provide mutation profiles for five tumor-normal paired CSCNETs using whole exome sequencing (WES). We expanded our assessment of frequently mutated genes to include publicly available data from 55 small intestine neuroendocrine tumors, 10

While numerous studies pertaining to the total synthesis of Cephalotaxus alkaloids have been reported, only two strategies have been reported to date for the successful synthesis of the C-11 oxygenated subset, due to the additional synthetic challenge posed by the remote C-11 stereocenter. Herein, we report the collective asymmetric total synthesis of C-11 oxygenated Cephalotaxus alkaloids using a chiral proline both as a starting material and as the only chirality source. A tetracyclic advanced

As transformed to aging society, many personal devices for healthcare have recently been developed. According to the increase of individual development of health devices, the ISO/IEEE 11073 PHD standard is established for gathering health measurement data. But many existing healthcare devices are not standardized. In this paper, we propose implementation model of standardization for legacy healthcare devices which do not follow 11073 PHD standard. We develop universal PHD Adapter (UPA) and UPA i

Our results demonstrate AD-specific changes in the miRNA regulatory system as well as the relationship between the expression levels of miRNAs and their targets in the hippocampus of Tg6799 mice. These data help further our understanding of the function and mechanism of various miRNAs and their target genes in the molecular pathology of AD.

We propose an activity recognition system especially for the elderly using a wearable sensor module including a triaxial accelerometer. We have mainly tackled easy battery loss problem minimizing the efficiency decrease of the activity recognition. The proposed system consists of main modules; sensor module, gateway, and PDA phone. The sensor module is worn at the left side of waistband, and the embedded algorithm installed in a microcontroller of the sensor module manipulates the sensing data i

Neovascular eye diseases are a major cause of blindness. Excessive angiogenesis is a feature of several conditions, including wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy of prematurity. Development of novel antiangiogenic small molecules for the treatment of neovascular eye disease is essential to provide new therapeutic leads for these diseases. We have previously reported the therapeutic potential of anti-angiogenic homoisoflavanone derivatives wit

A transition-metal-free 5- exo- dig asymmetric cyclization of α-amino ester enolates onto bromoalkynes provided a product with excellent enantioselectivity via the memory of chirality concept. This strategy was applied to a concise total synthesis of (-)-runanine and a formal synthesis of (-)-8-demethoxyrunanine and (-)-cepharatine D.

In comparison to modern methods for carbon–SF 5 bond formation, methods for direct heteroatom–SF 5 bond formation are exceptionally scarce, rendering motifs such as “ N –SF 5 ” virtually unexplored in the context of organic and medicinal chemistry. Herein, we demonstrate that direct N –SF 5 bond formation can be accomplished through strain-release pentafluorosulfanylation of 3-aryl [1.1.0]azabicyclobutanes (ABBs), using an easy-to-access solution of SF 5 Cl. To our surprise, the resultant N –SF

An efficient strategy for the asymmetric synthesis of Cα-tetrasubstituted proline derivatives from proline has been established. A nitrogen-fused bicyclic system was devised to control the stereodynamics of proline. Through N-quaternizations with allylic electrophiles followed by [2,3]-rearrangements, the bicyclic proline system delivered enantioenriched Cα-tetrasubstituted prolines. This strategy was applied to the concise total synthesis of (-)-amathaspiramide F.

Asymmetric synthesis of α-substituted proline derivatives has been accomplished by an efficient chirality-transfer method. High diastereoselectivity of the N-alkylation of the proline ester (C→N chirality transfer) was achieved when a 2,3-disubstituted benzyl group was used as the N-substituent. DFT calculations provided a mechanistic rationale for the high degree of stereoselectivity. The generated N-chirality of the quaternary ammonium salt was transferred back to the α-carbon through a stereo

This paper is concerned about a medication reminding service in home environments and its context reasoning method to recognize the service suitable for medication situation. To provide an appropriate medication service depending on the user's situation, it is needed to model and infer the context based on user's condition. In this paper, we proposed a method to organizing the context model and a reasoning engine to infer the service. We used jess rule engine to build our reasoning engine and su

A base-mediated aerobic oxidative cleavage of α-amino esters involving a hydroperoxide intermediate was reported, which represents the first example of the cleavage of the α-C–N bonds of amino acid derivatives without the aid of metal catalysts.