이수원 교수

Abstract Sensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor subunit that regulates long-term depression and circuit refinement during brain development, has been strongly implicated in ASD, but whether GRIN2B mutations lead to sensory abnormalities remains unclear. Here, we report that Grin2b -mutant mice show behavioral sensory hypersensitivity and brain hyperconnectivity a

BACKGROUND: Circulating tumor DNA (ctDNA) has emerged as a prognostic and predictive biomarker for detection of minimal residual disease (MRD), monitoring treatment response, and early detection of recurrence in cancer patients. In this study, we explored the utility of ctDNA-based MRD detection to predict recurrence in a real-world cohort of primarily early-stage non-small cell lung cancer (NSCLC) patients treated with curative intent. METHODS: Longitudinal plasma samples were collected post cu

BACKGROUND: Maintenance of stable blood pressure (BP) during cerebrovascular bypass surgery is crucial to prevent cerebral ischemia. We compared the effect of remimazolam anesthesia with that of propofol-induced and desflurane-maintained anesthesia on intraoperative hemodynamic stability and the need for vasoactive agents in patients undergoing cerebrovascular bypass surgery. METHODS: Sixty-five patients were randomized into remimazolam (n = 31, remimazolam-based intravenous anesthesia) and cont

Abstract Dopamine (DA) neurons in the ventral tegmental area (VTA) promote social brain functions by releasing DA onto nucleus accumbens neurons, but it remains unclear how VTA neurons communicate with cortical neurons. Here, we report that the medial prefrontal cortex (mPFC)-lateral hypothalamus (LH)-VTA pathway contributes to social deficits in mice with IRSp53 deletion restricted to cortical excitatory neurons ( Emx1-Cre;Irsp53 fl/fl mice). LH-projecting mutant mPFC neurons display abnormally

IRSp53 (or BAIAP2) is an abundant excitatory postsynaptic scaffolding/adaptor protein that is involved in actin regulation and has been implicated in autism spectrum disorders, schizophrenia, and attention-deficit/hyperactivity disorder. IRSp53 deletion in mice leads to enhanced NMDA receptor (NMDAR) function and social deficits that are responsive to NMDAR inhibition. However, it remains unclear whether IRSp53 re-expression in the adult IRSp53-mutant mouse brain after the completion of brain de

Desflurane is the most pungent of the currently used volatile anesthetics. We assessed whether the incidence of perioperative upper respiratory events in children undergoing general anesthesia via a supraglottic airway is higher with desflurane than with sevoflurane as maintenance anesthetic.We retrospectively reviewed and analyzed the electronic medical records of consecutive children 1 to 15 years of age who underwent general anesthesia via a supraglottic airway at Seoul National University Bu

Over the past decade or so, mouse models of autism spectrum disorders (ASD) have been extensively studied in the search for key mechanisms underlying the disorder. Numerous intriguing mechanisms have been proposed, spanning various levels of the neural system, including molecular, synaptic, neuronal, circuit, and systems-level processes. However, no single mechanism has emerged as universally applicable, highlighting the heterogeneous nature of the genetic and neurobiological underpinnings of AS

ABSTRACT: Motor-evoked potential (MEP) monitoring is an essential monitoring for clinicians to improve outcomes. Although unacceptable movement during MEP is a rare complication but it can lead to terrible results. The aim of this study was to evaluate the risk factors associated with unacceptable movements in patients undergoing brain surgery with MEP monitoring.We performed a retrospective observational study of patients who underwent brain surgery with MEP monitoring under general anesthesia

국내 하수는 C/N비가 낮아, 생물학적 질소제거 효율을 향상시키기 위해, 값비싼 외부 탄소원의 주입이 필요하다. Sulfide를 이용한 독립영양탈질은 경제성이 높은 무기물을 전자공여체로 이용하며, 부산물인 sulfate의 농도가 낮을 뿐 아니라 pH 저하가 작다는 장점이 있다. 본 연구에서는 sulfide를 탈질 전자 공여체로 이용하는 화학 양론식을 미생물의 성장에 기초하여 정립한 뒤, 하수 처리 공법에의 적용 가능성을 모색하였다. 하수처리장과 비슷한 조건인 공기의 유출입이 허용되는 무산소조에서는 질산성 질소와 산소가 공존할 경우 저농도 산소라 할지라도 우선적으로 sulfide와 반응하여 이론치보다 높은 S/N비가 필요하였고, 미생물 수율이 감소하는 현상이 관찰되었다. 그러나, 공기의 유출입이 없는 무산소조의 경우 질산성 질소의 감소, sulfide의 감소 및 알칼리도의 감소가 미생물의 성장과 비례적으로 나타났기 때문에 신뢰성 있는 화학 양론식의 도출이 가능하였다.

BACKGROUND: Deep neuromuscular blockade (NMB) optimizes surgical conditions, particularly during laparoscopic procedures. However, its effects on systemic cytokines associated with anesthesia-related complications, including postoperative delirium and cognitive dysfunction, remain unclear. In this review, we quantified the impact of deep NMB on serum cytokine levels. METHODS: PubMed, EMBASE, CENTRAL, CINAHL, Scopus, Web of Science, and Google Scholar databases were searched to identify randomize

We performed a study to investigate whether contamination of hemostasis samples with a glucose-containing solution might generate spurious results in rotational thromboelastometry (ROTEM) tests.Venous blood was taken from 12 healthy volunteers and divided into 4 specimen bottles, which were contaminated with different concentrations (0%, 5%, 10%, and 20%) of glucose solution.Significant lengthening of INTEMCT was observed in the 10% and 20% groups compared with baseline values (7.7% and 9%, P =

Background: Checkpoint inhibitor-associated pneumonitis (CIP) after immunotherapy has become a challenging issue in non-small cell lung cancer (NSCLC) patients. This study leverages artificial intelligence (AI) algorithms to analyze radiomic features, aiming to predict the occurrence of CIP, as well as tumor response. Methods: This study analyzed data from 159 stage III-IV NSCLC patients undergoing immunotherapy. The patients were categorized into pneumonitis and non-pneumonitis groups, and 3D r

A data-driven statistical analysis of the missile’s capture region is performed. The capture region is the region of the initial geometric configuration for pursuer missile against a target in which the missile can intercept the target while satisfying specific constraints. The statistical verification approach has advantages over the analytic approach in that it can deal with various guidance algorithms and target maneuver utilizing numerical simulator. In this study, the verification model is