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Acute kidney injury (AKI) is a common clinical syndrome that is characterized by abnormal renal function and structure. The Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference in 2019 reviewed the stages of AKI and the definitions of AKI-related terminologies, and discussed the advances in the last decade. Along with serum creatinine level and urine output, more accurate novel biomarkers for predicting AKI are being applied for the early detection of renal dysfunction. A l

BACKGROUND: Cephalosporin is a major offending agent in terms of drug hypersensitivity along with penicillin. Cephalosporin intradermal skin tests (IDTs) have been widely used; however, their validity for predicting immediate hypersensitivity has not been studied. This study aimed to determine the predictive value of cephalosporin intradermal skin testing before administration of the drug. METHODS: We prospectively conducted IDTs with four cephalosporins, one each of selected first-, second-, th

Abstract Little is known about the prevalence of chronic kidney disease (CKD) during the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the long-term trends in CKD prevalence from South Korea including the early pandemic. We used data from 108,152 Korean adults from 2007 to 2020 obtained from a representative longitudinal serial study. We defined CKD as a condition when the participant’s estimated glomerular filtration rate was < 60 mL/min/1.73 m 2 , or one-time spot pr

BACKGROUND AND OBJECTIVES: Basic fibroblast growth factor (bFGF) is a multifunctional cytokine that exerts positive regulation in hematopoiesis and that may also have a role in myelofibrosis and angiogenesis. We used bone marrow immunohistochemical stains to obtain additional insight into the cellular distribution of bFGF in both chronic myeloproliferative diseases (CMPD) and myelodysplastic syndrome (MDS). DESIGN AND METHODS: Bone marrow immunohistochemical stains were used to evaluate the cell

AIMS: Dystrophic neurites are associated with β-amyloid (Aβ) plaques in the brains of Alzheimer's disease (AD) patients and are also found in some specific areas of normal, aged brains. This study assessed the molecular characteristics of dystrophic neurites in normal ageing and its difference from AD. METHODS: We compared the dystrophic neurites in normal aged human brains (age 20-70 years) and AD brains (Braak stage 4-6) by immunostaining against ChAT, synaptophysin, γ-tubulin, cathepsin-D, Aβ

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. The clinical relevance of 11 urinary exosomal microRNAs (miRNAs) was evaluated in patients with IgAN. From January 2009 to November 2018, IgAN (n = 93), disease control (n = 11), and normal control (n = 19) groups were enrolled. We evaluated the expression levels of urinary exosomal miRNAs at the baseline and their relationship with clinical and pathologic features. This study aimed to discriminate stati

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Recent technological innovations in organic light-emitting diodes (OLEDs) have enabled their applicability to be expanded to not only displays but also the lighting industry. In addition, the high scalability and flexibility of OLEDs render them promising candidates for next-generation displays. However, their insufficient lifetime and low uniformity/stability are challenging issues, mainly because of inadequate understanding regarding the fundamental degradation mechanism of OLEDs owing to thei

Background: Vaccination is the long-term established measure for disease prevention and worldwide outbreak of COVID-19 necessitates mass scale vaccination. However, there is a public concern on the risk of renal adverse reactions from several types of vaccination. Methods: We analyzed VigiBase (n = 120,715,116 reports), the World Health Organization pharmacovigilance database from Dec 1967 to Jul 2022 using disproportionate Bayesian reporting. Information component (IC) compares observed and exp

Abstract This study evaluated the susceptibility effects using quantitative susceptibility mapping (QSM) as a marker for regional brain iron alternations in diabetic rat brains. Otsuka Long‐Evans Tokushima Fatty (OLETF) rats (n = 7) and age‐matched lean Long‐Evans Tokushima Otsuka (LETO) control rats (n = 8) were scanned using a three‐dimensional gradient‐echo sequence in a 3 Tesla MRI to map QSM. The correlation analysis was performed to evaluate the relationship between the QSM value and the b

Background Recently, the target systolic blood pressure (BP) <120 mm Hg was suggested in the population with chronic kidney disease. We aimed to determine the applicability of intensified BP and to assess the incidence of cardiovascular disease (CVD) in the population with chronic kidney disease. Methods and Results Participants who were >20 years old and had estimated glomerular filtration rate 15 to 60 mL/min per 1.73 m 2 during 2009 to 2011 were included from the database of Korean Nati

Introduction: Time in target range of systolic blood pressure (SBP-TTR) is the percentage of time that the SBP remains within 110-130 mm Hg. The association between the SBP-TTR and clinical outcomes in patients with chronic kidney disease (CKD) remains unclear. We evaluated the risks of cardiovascular disease (CVD), all-cause mortality, and renal events across the SBP-TTR groups. METHODS: Overall, 193,289 patients with CKD who underwent at least two health checkups between 2012 and 2015 were sel