김수아 교수

The depletion of claudin-2, occludin and ZO-1 in HK-2 cells had differential effects on TER and macromolecule flux. We demonstrated that integration of claudin-2, occludin and ZO-1 is necessary for maintaining the function of the proximal tubular epithelium.

Among patients who meet criteria for diabetes within 2 years, those who are elderly, have lower premorbid BMI, weight loss, no family history of DM, need screening of pancreatic cancer.

Impaired pressure natriuresis (PN) underlies salt-sensitive hypertension, and renal inflammation and hypoxia-inducible factor-1 (HIF-1) have been implicated in the modulation of systemic hypertension. Although sodium-glucose cotransporter-2 (SGLT2) inhibitors were reported to lower blood pressure (BP) in type 2 diabetes mellitus, whether they have a role in nondiabetic hypertensive kidney diseases is unclear. The present study was undertaken to investigate whether nondiabetic salt-sensitive hype

BACKGROUND: The high transmission and fatality rates of coronavirus disease 2019 (COVID-19) strain intensive care resources and affect the treatment and prognosis of critically ill patients without COVID-19. Therefore, this study evaluated the differences in characteristics, clinical course, and prognosis of critically ill medical patients without COVID-19 before and during the COVID-19 pandemic. METHODS: This retrospective cohort study included patients from three university-affiliated tertiary

Because cyclophosphamide-induced hyponatremia was reported to occur without changes in plasma vasopressin in a patient with central diabetes insipidus, we hypothesized that cyclophosphamide or its active metabolite, 4-hydroperoxycyclophosphamide (4-HC), may directly dysregulate the expression of water channels or sodium transporters in the kidney. To investigate whether intrarenal mechanisms for urinary concentration are activated in vivo and in vitro by treatment with cyclophosphamide and 4-HC,

Hyponatremia is frequently encountered in clinical practice and usually induced by renal water retention. Many medications are considered to be among the various causes of hyponatremia, because they either stimulate the release of arginine vasopressin (AVP) or potentiate its action in the kidney. Antidepressants, anticonvulsants, antipsychotics, diuretics, and cytotoxic agents are the major causes of drug-induced hyponatremia. However, studies addressing the potential of these drugs to increase

Preoperative staging chest CT is not beneficial to colon cancer patients without liver metastasis and lymph node metastasis suggested on abdominal and pelvic CT who had negative finding on initial CXR.

Severe LV systolic dysfunction and diffuse pattern of LV wall motion impairment significantly affected in-hospital mortality in patients with septic shock. Conventional echocardiographic evaluation provides adequate information on the development of myocardial damage and accurately predicts the prognosis of patients with septic shock.

It is unclear whether antipsychotic drugs can retain water in the kidney in the absence of vasopressin. This study demonstrates that haloperidol, sertraline, and carbamazepine can produce nephrogenic syndrome of inappropriate antidiuresis because they directly upregulate vasopressin-2 receptor and aquaporin-2 (AQP2) via cAMP/PKA signaling. We showed that, in addition to AQP2 trafficking, AQP2 protein abundance was rapidly increased by treatment with antipsychotic drugs in association with dephos

Cyclophosphamide is clinically useful in treating malignancy and rheumatologic disease, but has limitations in that it induces hyponatremia. The mechanisms by which cyclophosphamide induces water retention in the kidney have yet to be identified. This study was undertaken to test the hypothesis that cyclophosphamide may produce water retention via the proximal nephron, where aquaporin-1 (AQP1) and aquaporin-7 (AQP7) water channels participate in water absorption. To test this hypothesis, we gave

BACKGROUND: Left ventricular (LV) distension is a recognizable problem accompanied by subsequent complications during venoarterial extracorporeal membrane oxygenation (VA-ECMO). However, no gold standard for LV decompression has been established, and no minimal flow requirement has been designated. Thus, we evaluated the efficacy of the 8-Fr Mullins sheath for left heart decompression during VA-ECMO in adult patients. METHODS: Left heart decompression was performed when severe pulmonary edema wa

가정용 소셜 로봇이 진화함에 따라 인간과 로봇의 원활한 감정 교류 및 소통 방법에 관한 디자인 연구의 필요성이 대두되고 있다. 본 연구의 목적은 비언어 커뮤니케이션 디자인을 통한 로봇의 감정표현을 탐구하는 것이다. 본 연구의 연구방법은 다음과 같다. 1) 먼저 인간에게 시각적 영향을 미치는 로봇의 외형 디자인에 대한 선호도 조사를 진행하였다. 선호도 조사를 통해 로봇의 기본 형태를 추출하였다. 2) 추출한 기본형 로봇에 긍정을 나타내는 대표적인 동작언어인 고개 끄덕이기와 부정을 나타내는 고개 가로젓기를 대입하고, 동일한 동작 내에서 움직임의 범위가 다른 시뮬레이션을 제작하였다. 해당 시뮬레이션을 피실험자에게 보여주고 로봇의 동작 디자인에 따라 인식되는 감정에 대하여 범주화(Categorization)하였다. 3) 범주화된 동작 디자인의 움직임 범위 및 속도에 따라 참가자가 느끼는 감정의 유형을 조사하였다. 연구결과는 다음과 같다. 첫째, 인간은 로봇의 머리 움직임을 통해 감정을 인식

This paper presents a high-speed LVDS I/O interface for mobile DRAMs. A data rate of 6Gbps/pin and a transmit-jitter of 57.31ps pk-pk were demonstrated, in which an 800MHz clock and a 200mV swing were used. The power consumption by I/O circuit is 6.2mW/pin when a 10pf load is connected to the I/O, and output supply voltage is 1.2V. The proposed mobile DRAM has 6 data pins and 4 address/command pins for a multi-chip package (MCP). The transmitter uses a feed-back LVDS output driver and a common-m