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Gastritis, peptic ulcer disease, and gastric cancer are a few of the diverse disease manifestations that have been shown to be associated with infection by Helicobacter pylori. Why some individuals develop more severe forms of disease remains largely unknown. In this study, 225 South Korean strains were genotyped for vacA and then analyzed to determine if particular genotypes varied across disease state, sex, or cagA allele. Of these strains, 206 strains carried an s1/i1/m1 allele, 11 strains ca

Type 1 diabetes with periodontitis shows elevated TNF-α expression. Tumor necrosis factor (TNF)-α stimulates the expression of receptor activator of nuclear factor-κB ligand (RANKL) and sclerostin. The objective of this study was to determine the effect of TNF-α expression of osteocytic RANKL and sclerostin in type 1 diabetes rats with periodontitis using infliximab (IFX), a TNF-α antagonist. Rats were divided into two timepoint groups: day 3 and day 20. Each timepoint group was then divided int

Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with an unknown etiology. The role of oral microbes in the development of OLP has gained researchers' interest. In this review, we summarized the findings of studies focused on the relationship between OLP and oral microbiome, which includes the composition of oral microbiota, molecules produced by oral microbiota or the host, and the oral environment of the host. According to the studies, the oral microbial community

ABSTRACT Infection with Helicobacter pylori is a major risk factor for development of gastric disease, including gastric cancer. Patients infected with H. pylori strains that express CagA are at even greater risk of gastric carcinoma. Given the importance of CagA, this report describes a new molecular mechanism by which the cagA copy number dynamically expands and contracts in H. pylori . Analysis of strain PMSS1 revealed a heterogeneous population in terms of numbers of cagA copies; strains car

Helicobacter pylori is the major risk factor for gastric cancer. H. pylori harboring the type IV secretion system (T4SS) and its effector CagA encoded on the cag pathogenicity Island (cagPAI) increases the risk. H. pylori PMSS1 has a multi-cagA genotype, modulating cagA copy number dynamically from zero to four copies. To examine the effect of the immune response on cagA copy number change, we utilized a mouse model with different immune status. PMSS1 recovered from Rag1−/− mice, lacking functio

Helicobacter pylori (H. pylori) is a human gastric pathogen, causing various gastric diseases ranging from gastritis to gastric adenocarcinoma. It has been reported that combining N-acetylcysteine (NAC) with conventional antibiotic therapy increases the success rate of H. pylori eradication. We evaluated the effect of NAC itself on the growth and colonization of H. pylori, and development of gastritis, using in vitro liquid culture system and in vivo animal models. H. pylori growth was evaluated

This study demonstrated that nasal obstruction induced mouth breathing led to hypoxia in a rat model. Under hypoxic conditions, an increase in osteoclast differentiation induced by activation of the inflammatory pathway causes destructive changes in the alveolar bone.

Helicobacter pylori (H. pylori) is a human gastric pathogen,causing various gastric diseases ranging from gastritis to gastricadenocarcinoma. It has been reported that combiningN-acetylcysteine (NAC) with conventional antibiotic therapyincreases the success rate of H. pylori eradication. We evaluatedthe effect of NAC itself on the growth and colonizationof H. pylori, and development of gastritis, using in vitroliquid culture system and in vivo animal models. H. pylorigrowth was evaluated in brot

Helicobacter pylori is a major pathogen causing various gastric diseases including gastric cancer. Infection of H. pylori induces pro-inflammatory cytokine IL-8 expression in gastric epithelial cells in the initial inflammatory process. It has been known that H. pylori can modulate Ras-Raf-Mek-Erk signal pathway for IL-8 induction. Recently, it has been shown that another signal molecule, cancer Osaka thyroid oncogene/tumor progression locus 2 (Cot/Tpl2) kinase, activates Mek and Erk and plays a

To evaluate the inhibitory activity of wogonin against lipopolysaccharide (LPS)-induced bone resorption, we investigated the effect of wogonin on osteoclastogenesis induced by LPS. Wogonin inhibited LPS-induced osteoclastogenesis in co-cultures of mouse calvaria-derived osteoblasts and bone marrow-derived pre-osteoclasts. Wogonin also suppressed osteoclastogenesis in LPS-injected mouse calvaria. In osteoblasts, the upregulation of receptor activator of nuclear factor-kappaB (RANKL) expression an

Helicobacter pylori is a major pathogen causing various gastricdiseases including gastric cancer. Infection of H. pyloriinduces pro-inflammatory cytokine IL-8 expression in gastricepithelial cells in the initial inflammatory process. It has beenknown that H. pylori can modulate Ras-Raf-Mek-Erk signalpathway for IL-8 induction. Recently, it has been shown thatanother signal molecule, cancer Osaka thyroid oncogene/tumorprogression locus 2 (Cot/Tpl2) kinase, activates Mek andErk and plays a role in

Helicobacter pylori infection causes chronic inflammation in the stomach, which is linked to the development of gastric cancer. The anti-inflammatory and anticancer effects of a glycolysis inhibitor 2-deoxyglucose (2DG) and an antidiabetic medication metformin (Met) have gotten attention. Using a Mongolian gerbil animal model, we investigated H. pylori-mediated gastric pathogenesis and how this pathogenesis is influenced by 2DG and Met. Five-week-old male gerbils were infected with H. pylori str

본 논문은 치과용 X-ray 장비의 실험 및 결과를 바탕으로 유연 다물체 동역학 모델링을 통해 검증 결과를 제시한다. 치과용 X-ray 장비는 육안으로 볼 수 없는 치아 구조를 관찰하고 악성 치아, 턱 관절의 손실 및 공동을 찾는데 사용된다. 장비 구동부가 구동하면서 인간의 치아와 턱관절의 전체적인 형상을 촬영한다. 그러나 촬영 중 미세 진동으로 인한 촬영 품질 저하가 발생하는 문제가 있다. 이러한 문제점을 파악하기 위해 CMS(component mode synthesis) 기법 중 하나인 Craig-Bampton 방법을 기반으로 한 모달 해석을 수행하여 주요 프레임의 주파수를 분석하고 해당 주파수를 모드 좌표로 사용하였다. 그리고 구동 요소의 미세 진동을 파악하기 위해 베어링과 벨트 모델링 그리고 base와 지면 사이의 접촉 모델링을 진행하고 실제 장비의 실험 데이터를 사용하여 모델 검증을 수행하였다.

The dye-sensitized solar cells (DSSCs) examine long-term stability tests were prepared to SnO2:F (FTO) glass substrates patterned by the etching method were applied to the electrode on the device using polyethyleneglycol (PEG) electrolyte. We investigated the effect of patterned SnO2:F (FTO) glass substrates on the power conversion efficiency and long-term stability of DSSCs. The patterned devices maintained over 83% of its initial overall power conversion efficiency after 720 hours aging at roo