안성귀 교수

Purpose: Bone is the most frequent site of metastasis among breast cancer patients. We investigated prognostic factors affecting survival following bone-only metastasis in breast cancer patients. Materials and Methods: The medical records of breast cancer patients who were treated and followed at Gangnam Severance Hospital retrospectively reviewed to identify patients with bone-only metastasis. Results: The median time from the diagnosis of bone-only metastasis to the last follow-up or death was

Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer. To dissect the molecular diversity of TNBC and discover therapeutic targets for TNBC, the molecular classification of TNBC is a prioritized issue in research area. Accordingly, recent studies have been successful in classifying TNBC into several distinct subtypes with specific biologic pathways. Despite the different methodologies used and varied number of final subtypes, these stud

Purpose: The p53 gene is one of the most frequently mutatedgenes in breast cancer. We investigated the patterns and biologicfeatures of p53 gene mutation and evaluated their clinical significancein Korean breast cancer patients. Methods: Patients whounderwent p53 gene sequencing were included. Mutational analysisof exon 5 to exon 9 of the p53 gene was carried out usingpolymerase chain reaction-denaturing high performance liquidchromatography and direct sequencing. Results: A total of 497patients

Purpose: There is still a clinical need to easily evaluate the metastatic status of lymph nodes during breast cancer surgery. We hypothesized that ex vivo shear-wave elastography (SWE) would predict precisely the presence of metastasis in the excised lymph nodes. Methods: A total of 63 patients who underwent breast cancer surgery were prospectively enrolled in this study from May 2014 to April 2015. The excised axillary lymph nodes were examined using ex vivo SWE. Metastatic status was confirmed

Purpose: To evaluate the influence of preoperative mechanical bowel preparation (MBP) based on the occurrence of anastomosis leakage, surgical site infection (SSI), and severity of surgical complication when performing elective colorectal surgery. Materials and Methods: MBP and non-MBP patients were matched using propensityscore. The outcomes were evaluated according to tumor location such as right- (n=84) and left-sided colon (n=50) and rectum (n=100). In the non-MBP group, patientswith right-s

Purpose: We investigated the relationships between metastasisfree interval (MFI) and tumor characteristics, and assessed the prognostic value of MFI for survival after metastasis in patients with metastatic breast cancer. Furthermore, we compared MFI among the subtypes. Methods: We identified 335 patients with postoperative tumor recurrence at distant site(s). All patients underwent curative resection and had a MFI of at least 6 months. MFI was categorized as short (<2 years), intermediate (≥2 y

The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase III study (EMBRACE), eribulin improved overall survival in patients with heavily pretreated metastatic breast cancers. However, these studies included few patients with brain metastases. Metastatic brain tumors (MBT) were detected during first-line palliative chemotherapy in a 43-year-old woman wi

Purpose: In properly selected patients with breast cancer, nipplesparing mastectomy (NSM) is generally considered safe by oncologic standards. We examined two groups of patients who underwent direct-to-implant (DTI) reconstruction after NSM, comparing complications encountered, revision rates, and aesthetic outcomes. The patients were stratified based on type of surgical incision and assigned to inframammary fold (IMF) and non-IMF groups. Methods: We investigated 141 patients (145 breasts) subje

Purpose: The prognosis of breast cancer has been consistently improving. We analyzedour cohort of breast cancer patients with a long-term follow up at a single center over time. Materials and Methods: A total of 1889 patients with known cancer stages were recruited and analyzed between January 1991 and December 2005. Patients were classified according to the time periods (1991--1995; 1996--2000; 2001--2005). To determine intrinsic subtypes, 858 patients whose human epidermal growth receptor-2 st

Purpose Although sentinel lymph node biopsy (SLNB) can accurately represent the axillary lymph node (ALN) status, the false-negative rate (FNR) of SLNB is the main concern in the patients who receive SLNB alone instead of ALN dissection (ALND). Materials and Methods We analyzed 1,886 patients who underwent ALND after negative results of SLNB, retrospectively. A logistic regression analysis was used to identify risk factors associated with a falsenegative (FN) result. Cox regression model was use

Purpose: A growing body of evidence indicates that zoledronicacid (ZA) can improve the clinical outcome in patients withbreast cancer and low estrogen levels. In the present study, weaimed to investigate the survival benefit of ZA administration inpostmenopausal Korean women with breast cancer who werealso receiving aromatase inhibitors. Methods: Between January2004 and December 2010, 235 postmenopausal breast cancerpatients undergoing aromatase inhibitor therapy were investigated. All patients

Purpose: Breast cancer is heterogeneous disease and the response to chemotherapeutic agents is also heterogeneous from patient to patient. Chemotherapy response assay is in vitro test that is performed to evaluate the degree of tumor growth inhibition by chemotherapy drugs. In this study, we performed the chemotherapy response assay using adenosine triphosphate (ATP-CRA) in breast cancer patients and assessed the clinical availability. Methods: Sixty five breast cancer patients were enrolled in

Purpose: To investigate treatment options for local control of metastasisin the brain, we compared focal brain treatment (FBT)with or without whole brain radiotherapy (WBRT) vs. WBRT alone,for breast cancer patients with tumor relapse in the brain. We alsoevaluated treatment outcomes according to the subtypes. Methods:We conducted a retrospective review of breast cancer patientswith brain metastasis after primary surgery. All patients receivedat least one local treatment for brain metastasis. Su

최근 대학생들은 취업을 비롯한 여러 가지 원인으로 스트레스를 많이 받고 있다. 따라서 이들의 건강에 중요한 영향을 미치는 스트레스 수준과 식습관을 살펴보고, 이들의 관계를 알아보고자 하였다.

With the advance in personalized therapeutic strategies in patients with breast cancer, there is an increasing need for biomarker-guided therapy. Although the immunogenicity of breast cancer has not been strongly considered in research or practice, tumor-infiltrating lymphocytes (TILs) are emerging as biomarkers mediating tumor response to treatments. Earlier studies have provided evidence that the level of TILs has prognostic value and the potential for predictive value, particularly in triple-