김성완 교수

Abstract The swelling of crosslinked poiy( N , N ′‐alkyl substituted acrylamides) in water was studied in relation to temperature changes. Conventional swelling theory and separation of the polymer solvent interaction parameter into enthalpic and entropic contributions were used to characterize the temperature dependence of swelling in water. The thermosensitivity of swelling can be attributed to the delicate hydrophilic/hydrophobic balance of polymer chains and is affected by the size, configur

Aqueous solutions of poly(ethylene glycol-b-[DL-lactic acid-co-glycolic acid]-b-ethylene glycol) (PEG-PLGA-PEG) triblock copolymers form a free-flowing sol at room temperature and become a gel at body temperature. In this study, in situ gel formation was investigated in rats. Upon subcutaneous injection of 33 wt % aqueous solutions of PEG-PLGA-PEG triblock copolymer into rats, transparent gels were observed. The gel showed good mechanical strength and the integrity of gels persisted longer than

Heparin was immobilized onto segmented polyurethane-urea surfaces (Biomer) using hydrophilic poly(ethylene oxide) spacers of different chain lengths. The use of the hydrophilic spacer, poly(ethylene oxide), reduces protein adsorption and subsequent platelet adhesion on the surface. In addition, the bioactivity of the immobilized heparin is enhanced by the incorporation of these spacers. Immobilized heparin bioactivity is shown to be a function of PEO spacer length. Use of hydrophilic PEO spacers