김태열 교수

Immune-related adverse events, including immune hemolytic anemia, have been reported in patients treated with immune checkpoint inhibitors. In particular, RBC autoantibodies are important because they can cause hemolytic anemia and interfere with pre-transfusion tests. On the other hand, there are few reports on the characteristics of RBC autoantibodies induced by immune checkpoint inhibitors in Korea. The medical history and laboratory results, including pretransfusion tests of ten patients tre

RHD-CE-D hybrid형의 유전자 변이는 RHD 유전자와 RHCE 유전자의 교차 위치에 따라 D 음성 혹은 부분-D형의 표현형을 보인다. 그간 국내에서 보고된 바로는 D 음성의 표현형을 보이는 hybrid형으로 RHD-CE(2-9)-D가 유일했다. 이에 본 연구팀은 심부전으로 외래 방문한 D 음성 환자에서 RHD-CE(3-8)-D hybrid형을 발견하여 국내에서 최초로 보고하는 바이다. 본 환자는 자동혈액형검사장비(QWALYS-3 system; DIAGAST, France)에 의해 D 음성이었고, 약-D 검사에서 약양성 반응을 보였으나 직접 항글로불린검사에서도 약양성을 보여 약-D 검사 결과가 위양성일 가능성을 배제할 수 없었다. 이에 정확한 RhD 유형을 확인하고자 유전자 검사를 시행하였고, 중합효소연쇄반응과 직접염기서열분석법을 통해 D 음성 표현형을 보이는 대립유전자로 알려진 RHD-CE(3-8)-D hybrid형을 확인하였다. 추후 다시 내원한 환자의 정맥혈 검체를 이용

Weak D type 102 allele (RHD*01W.102) carrying a missense variant (c.73A＞T, p.Ile25Phe) in exon 1 of the RHD has not been reported in Koreans to date. This is the first report of the weak D type 102 allele in the Korean population. The proposita, a 35-year-old woman, showed a serological weak D phenotype in routine RhD typing. Sequencing of all 10 RHD exons and zygosity testing targeting the hybrid Rhesus box revealed this proposita to harbor the weak D type 102 allele, as well as an RHD deletion

Cis-AB and B(A) alleles encode an ABO enzyme with dual A and B glycosyltransferase activity. Although globally rare, the cis-AB phenotype is found relatively often in Korean, Japanese, and Chinese populations. Cases of the B(A) allele have been reported mostly in the Chinese population. Forward typing performed in a Cambodian woman with an ABO discrepancy demonstrated a strong reaction with anti-A and anti-B reagents, while there was no reaction with lectin anti-A1. The anti-A1 antibody was dete

Background: The growing burden of nontuberculous mycobacteria (NTM) raises concerns regarding cross-reactivity in molecular tuberculosis (TB) diagnostics. In the current study, we evaluated whether high NTM loads affect Mycobacterium tuberculosis (MTB) detection or rifampin (RIF) resistance calls using Xpert MTB/RIF (Xpert) and Xpert MTB/RIF Ultra (Xpert Ultra). Methods: In vitro spiking experiments were performed by mixing eight NTM species (1 × 106 colony-forming unit [CFU]/mL) with heat-inact

Background: To overcome the labor-intensive and technician-dependent nature of the formalin–ether concentration technique (FECT), artificial intelligence (AI)-based automated feces analyzers have been developed for detecting fecal parasites. This study compared the clinical performance of the KU-F40 AI-based automated system with that of FECT in a routine diagnostic environment. Methods: In total, 1,011 fecal samples were prospectively collected and analyzed concurrently via both FECT and the