김태형 교수

Nanotheranostics, the integration of diagnostic and therapeutic function in one system using the benefits of nanotechnology, is extremely attractive for personalized medicine. Because treating cancer is not a one-size-fits-all scenario, it requires therapy to be adapted to the patient's specific biomolecules. Personalized and precision medicine (PM) does just that. It identifies biomarkers to gain an understanding of the diagnosis and in turn treating the specific disorder based on the precise d

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease and characterized by abnormal growth of fibroblasts and lung scarring. While the pathogenesis of IPF is not clearly understood, activation of transforming growth factor-β (TGF-β) and disruption of alveolar basement membrane seem to play important roles in leading to excess disruption of the matrix, which is associated with activated matrix metalloproteinase (MMP) and aberrant proliferation of myofibroblasts. The Wnt/β-cat

지구 온난화의 주요원인이 CO2 발생이고, 전 세계적으로 CO2 발생에 대한 규제가 강화되고 있다. 반 환경산업으로 인식되는 건설 산업의 주요자재로서 다량의 CO2를 배출하는 콘크리트는 생산과정에서 발생된 CO2 배출량 감소에 대한 필요성이 인식되었다. 콘크리트를 기초로 하여 자재생산, 운송, 제조단계에서 발생하는 CO2 배출량을 평가하기 위한 시스템을 구축하고, CO2 배출량을 효율적으로 저감하고 평가하기 위한 프로그램을 개발 하였다. 평가결과, 대부분의 CO2 배출량은 자재생산단계에서 발생했으며, 자재, 운송, 제조단계에서 배출된 CO2 배출량에 대하여 정량적으로 평가하였다. 더욱이, CO2 배출량을 저감하기 위하여 각 단계별로 친환경 기술을 적용하여 평가가 가능한 본 평가시스템은 콘크리트 생산에 따른 CO2 배출량을 정량적으로 평가하기 위한 시스템으로 제안할 수 있으며, 국내 레미콘생산업체는 CO2 배출량 평가를 하기 위해 이 시스템을 사용할 수 있다.

Insulin-like growth factor (IGF)-1 is increased in different models of acute lung injury, and is an important determinant of survival and proliferation in many cells. We previously demonstrated that treatment of mice with IGF-1 receptor-blocking antibody (A12) improved early survival in bleomycin-induced lung injury. We have now examined whether administration of A12 improved markers of lung injury in hyperoxia model of lung injury. C57BL/6 mice underwent intraperitoneal administration of A12 or

Heterostructures of metal halide perovskites and TiO x are efficient photocatalytic materials owing to the combination of the high absorption coefficients and long charge-carrier lifetimes of perovskites, and efficient photocatalytic activity of TiO x .

A single-frequency, unidirectional ring laser with a first order Laguerre-Gaussian (LG01) mode output end-pumped by using a ring-shaped pump beam is reported. This approach has been applied to a diode-pumped Nd:YVO4 laser in a traveling wave resonator configuration yielding 2.1 W and 1.5 W of single-frequency LG01 mode outputs with helical wavefronts of left- and right-handedness, respectively. Moreover, we show that its wavefront helicity can be switched by changing the lasing direction and fre

The Wnt signaling pathway has regulatory roles in cell proliferation, differentiation, andpolarity. Aberrant Wnt pathway regulation can lead to abnormal cell proliferation andcancer, and loss of Wnt7a expression has been demonstrated in lung cancer cell lines. E-cadherin keeps intercellular integrity and prevents metastasis. Therefore, E-cadherin hasbeen known as a prognostic factor in cancer. In the present study, we investigated theE-cadherin expression status by immunohistochemical stain and

BACKGROUND: Presence of purulent sputum during an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is considered sufficient indication for starting empirical antibiotics. We investigated the relationship between detection of potentially pathogenic bacteria (PPB) using sputum culture or polymerase chain reaction (PCR) and clinical response and sought the risk factors for PPB growth. METHODS: In 342 outpatients with AECOPD, we compared detection rates of H. influenzae (HI) and

The resistance spot welding is one of the most commonly used welding process for joining the sheet metal in automotive manufacturing process due to higher deposition rates and higher economy achieved. Control variables in the resistance spot welding for achieving high quality are welding current, welding force and welding time. Generally at the manufacturing scene, welding current Vs welding time lobe diagram is used to estimate weldability because controlling welding force is not practical due