장원석 교수

Our results demonstrate that MRgFUS thalamotomy is a safe, effective and less-invasive surgical method for treating medication-refractory ET. However, several issues must be resolved before clinical application of MRgFUS, including optimal patient selection and management of patients during treatment.

OBJECTIVE: Magnetic resonance-guided focused ultrasound surgery (MRgFUS) was recently introduced as treatment for movement disorders such as essential tremor and advanced Parkinson's disease (PD). Although deep brain target lesions are successfully generated in most patients, the target area temperature fails to increase in some cases. The skull is one of the greatest barriers to ultrasonic energy transmission. The authors analyzed the skull-related factors that may have prevented an increase in

OBJECT: Whole-brain radiation therapy (WBRT), open resection, and stereotactic radiosurgery (SRS) are widely used for treatment of metastatic brain lesions, and many physicians recommend WBRT for multiple brain metastases. However, WBRT can be performed only once per patient, with rare exceptions. Some patients may require SRS for multiple metastatic brain lesions, particularly those patients harboring more than 10 lesions. In this paper, treatment results of SRS for brain metastasis were analyz

Voltage-gated sodium channels (Navs) play an important role in human pain sensation. However, the expression and role of Nav subtypes in native human sensory neurons are unclear. To address this issue, we obtained human dorsal root ganglion (hDRG) tissues from healthy donors. PCR analysis of seven DRG-expressed Nav subtypes revealed that the hDRG has higher expression of Nav1.7 (~50% of total Nav expression) and lower expression of Nav1.8 (~12%), whereas the mouse DRG has higher expression of Na

BACKGROUND: The persistence of adult hippocampal neurogenesis (AHN) is sharply decreased in Alzheimer's disease (AD). The neuropathologies of AD include the presence of amyloid-β deposition in plaques, tau hyperphosphorylation in neurofibrillary tangles, and cholinergic system degeneration. The focused ultrasound (FUS)-mediated blood-brain barrier opening modulates tau hyperphosphorylation, the accumulation of amyloid-β proteins, and increases in AHN. However, it remains unclear whether FUS can

Abstract Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies, but this is rarely reported in clinical studies. This study was conducted to evaluate the safety, feasibility and potential benefits of repeated extensive BBB opening. Methods In this open-label, prospective study, six patients with Alzheimer’s disease (AD) were enrolled at Severance Hospital in Kore

Quality of life is higher after microsurgery than after radiosurgery. One specific management strategy cannot always guarantee the better quality of life. The functional status and personality traits of the patient should be considered, as well as tumor size and location when choosing a management option.

Intrathecal baclofen (ITB) has been known to reduce spasticity which did not respond to oral medications and botulinum toxin treatment. However, few results have been reported comparing the effects of ITB therapy in patients with cerebral palsy (CP) and acquired brain injury. This study aimed to investigate beneficial and adverse effects of ITB bolus injection and pump therapy in patients with CP and to compare outcomes to patients with acquired brain injury such as traumatic brain injury and hy

스마트폰에서 위치 기반 서비스를 제공하는 증강현실 애플리케이션은 사용자에 대한 고려와 새로운 사용성 평가 방법을 요구하고 있다. 본 연구는 이러한 증강현실 애플리케이션개발과 사용성 평가를 위한 사용성 원칙을 개발하고 이에 대한 전문가 평가를 목적으로 한다. 기존 연구와 스마트폰의 증강현실 애플리케이션의 특징 분석을 바탕으로 사용성 원칙을개발하였다. 개발된 사용성 원칙을 이용하여 현재 대표적으로 사용되고 있는 세 개의 애플리케이션에 대해 전문가 평가를 수행한 결과 도출된 문제 리스트 중 세 가지 애플리케이션에 공통적으로 해당되면서 심각한 문제로 지적된 여섯 가지 문제 리스트와 개선을 위한 디자인 가이드라인이 도출되었다. 이 가이드라인을 통해 개선된 프로토타입을 제작하고 사용자 테스트를 진행하여 본 연구의 사용성 원칙과 전문가 평가의 효과성을 검증하였다. 본 연구의 결과는 스마트폰의 증강현실 애플리케이션에 대한 사용성 원칙 제시와 새로운 기술에대한 사용성 원칙 개발을 통해 디자인 방향을

Therefore, it could be a promising treatment for neurodegenerative diseases as it remarkably increases LTP, thereby improving working memory.

Although there have been reports of promising results regarding the transplantation of mesenchymal stem cells (MSCs) for neurodegenerative diseases through the use of neuronal differentiation or control of the microenvironment, traditional surgical transplantation methods like parenchymal or intravenous injection have limitations such as secondary injuries in the brain, infection, and low survival rate of stem cells in the target site. Focused ultrasound (FUS) treatment is an emerging modality f