최원석 교수

The clinical features of MERS-CoV infection in the Republic of Korea were similar to those of previous outbreaks in the Middle East. However, the overall mortality rate (20.4%) was lower than that in previous reports. Enhanced surveillance and active management of patients during the outbreak may have resulted in improved outcomes.

An integrin found on platelets, α(IIb)β(3) mediates platelet aggregation, and α(IIb)β(3) antagonists are effective antithrombotic agents in the clinic. Ligands bind to integrins in part by coordinating a magnesium ion (Mg(2+)) located in the β subunit metal ion-dependent adhesion site (MIDAS). Drugs patterned on the integrin ligand sequence Arg-Gly-Asp have a basic moiety that binds the α(IIb) subunit and a carboxyl group that coordinates the MIDAS Mg(2+) in the β(3) subunits. They induce confor

PURPOSE: To compare the surgical outcome of a lamellar macular hole (LMH) depending on lamellar hole-associated epiretinal proliferation (LHEP) and full-thickness macular hole. METHODS: This is a retrospective chart review. Thirty-three patients were enrolled for this study. The patients were divided into three groups depending on the type of macular hole and presence of LHEP. Group 1 had epiretinal membranes with LMH without LHEP, Group 2 had LMH with LHEP, and Group 3 had full-thickness macula

Recent studies have demonstrated that genomes of poliovirus with deletions in the P1 (capsid) region contain the necessary viral information for RNA replication. To test the effects of the substitution of foreign genes on RNA replication and protein expression, chimeric human immunodeficiency virus type 1 (HIV-1)-poliovirus genomes were constructed in which regions of the gag, pol, or env gene of HIV-1 were substituted for regions of the P1 gene in the infectious cDNA clone of type 1 Mahoney pol

BACKGROUND: From 2002 through 2006, Republic of Korea conducted extensive measles elimination activities and declared elimination in 2006. An outbreak of measles involving 180 confirmed cases occurred during 2007. METHODS: An outbreak investigation was performed and enhanced surveillance was implemented. Detailed case investigations and laboratory testing included serologic and molecular diagnostic methods. Cases were classified according to World Health Organization and national guidelines. RES

정보량의 기하급수적 증가에 따라 수많은 정보와 상품을 탐색하고 다양한 선택 대안들중에서 최선의 결정을 내리는 과정은 더 많은 시간과 인지적 노력을 소비자들에게 요구하고 있다. 결정 장애와 햄릿 증후군이라는 신조어를 만들어 낸 정보와 상품의 과잉 환경은 적은 노력으로 좋은 선택을 할 수 있도록 도와주는 큐레이션 서비스의 필요성과 가치를 더욱 높이고 있다. 이 연구는 소비자들의 제품 선호도와 취향을 분석하여 개인 맞춤형 상품 추천을 제공함으로써 쇼핑 피로감을 낮추고 소비 욕구를 높일 수 있는 큐레이션 쇼핑 서비스에 대한 소비자의 반응에 영향을 주는 요인들을 파악했다. 연구 모형 검증 결과, 큐레이션 쇼핑 서비스의 개인화 수준을 이용자들이 지각한 인지된 개인화는 큐레이션 쇼핑의 유용성, 신뢰도, 태도를 매개로 종속 변수인 클릭 의도, 구매 의도, 서비스 이용 의도에 유의한 영향을 미치는 것으로 확인되었다. 또한 개인차 변인으로 고려된 종결 욕구의 조절 효과가 유의미한 것으로 분석되었다.

Acinetobacter baumannii has been increasingly reported as a significant causative organism of various nosocomial infections. Here we describe an outbreak of carbapenem-resistant A. baumannii (CRAB) in the ICUs of a Korean university hospital, along with a successful outbreak control program. From October 2007 through July 2008, CRAB was isolated from 57 ICU patients. Nineteen patients were diagnosed as being truly infected with CRAB, four of whom were presumed to have died due to CRAB infection,

Integrin αIIbβ3 plays a central role in hemostasis and thrombosis. We provide the first 3-dimensional reconstruction of intact purified αIIbβ3 in a nanodisc lipid bilayer. Unlike previous models, it shows that the ligand-binding head domain is on top, pointing away from the membrane. Moreover, unlike the crystal structure of the recombinant ectodomain, the lower legs are not parallel, straight, and adjacent. Rather, the αIIb lower leg is bent between the calf-1 and calf-2 domains and the β3 Inte

Large-sized or deep skin wounds require skin substitutes for proper healing without scar formation. Therefore, multi-layered skin substitutes that mimic the genuine skin anatomy of multiple layers have attracted attention as suitable skin substitutes. In this study, a novel skin substitute was developed by combining the multi-layer skin tissue reconstruction method with the combination of a human-derived keratinic extract-loaded nano- and micro-fiber using electrospinning and a support structure

The determinants of immune recognition by five monoclonal antibodies (KK5, KK9, KK17, Senv7.1, and Senv101.1) that neutralize simian immunodeficiency virus infectivity were analyzed. These five neutralizing monoclonal antibodies were generated to native SIVmac251 envelope glycoprotein expressed by a vaccinia virus recombinant vector. All five recognize conformational or discontinuous epitopes and require native antigen for optimal recognition. These monoclonal antibodies also recognize SIVmac239

With inherent algorithmic error resilience of deep neural networks (DNNs), supply voltage scaling could be a promising technique for energy efficient DNN accelerator design. In this paper, we propose novel error resilient techniques to enable aggressive voltage scaling by exploiting different amount of error resilience (sensitivity) with respect to DNN layers, filters, and channels. First, to rapidly evaluate filter/channel-level weight sensitivities of large scale DNNs, first-order Taylor expan

[This corrects the article on p. 68 in vol. 47, PMID: 25844267.].

Acinetobacter baumannii has been increasingly reported as a significant causative organism of various nosocomial infections. Here we describe an outbreak of carbapenemresistant A. baumannii (CRAB) in the ICUs of a Korean university hospital, along with a successful outbreak control program. From October 2007 through July 2008, CRAB was isolated from 57 ICU patients. Nineteen patients were diagnosed as being truly infected with CRAB, four of whom were presumed to have died due to CRAB infection,