금웅섭 교수

Objective: To investigate the correlation between quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) parameters and microvascular density (MVD) in a human-colon-cancer xenograft mouse model using 3 Tesla MRI. Materials and Methods: A human-colon-cancer xenograft model was produced by subcutaneously inoculating 1 x 106 DLD-1 human-colon-cancer cells into the right hind limbs of 10 mice. The tumors were allowed to grow for two weeks and then assessed using MRI. DCE-MRI was

Background: This study aimed to assess the recent changes of radiation therapy (RT) modalities in Korea. In particular, we focused on intensity-modulated radiation therapy (IMRT) utilization as the main index, presenting the application status of advanced RT. Methods: We collected information from the Korean Health and Insurance Review and Assessment Service data based on the National Health Insurance Service claims and reimbursements records by using treatment codes from 2010 to 2016. We classi

Purpose: Local recurrence is the most common cause of failure in retroperitoneal soft tissue sarcoma patients after surgical resection. Postoperative radiotherapy (PORT) is infrequently used due to its high complication risk. We investigated the efficacy ofPORT using modern techniques in patients with retroperitoneal soft tissue sarcoma. Materials and Methods: Eighty patients, who underwent surgical resection for non-metastatic primary retroperitoneal soft tissuesarcoma at the Yonsei Cancer Cent

Purpose The Korean Society of Radiation Oncologists (KOSRO) conducted the Patterns of Care Study (PCS) of radiotherapy (RT) for spine metastases in 2009. The current study was conducted to investigate current practice patterns and compare them with the results of the PCS. Materials and Methods The survey questionnaire was composed of 10 questions regarding general information and seven questions for each of two clinical scenarios. Results Fifty-four members of the KOSRO answered at least one que

Purpose: The purpose of this study was to investigate the predictability of pretreatment values including Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) derived parameters (Ktrans, Kep and Ve), early changes in parameters (Ktrans, tumor volume), and heterogeneity (standard deviation of Ktrans) for radiation therapy responses via a human colorectal cancer xenograft model. Materials and Methods: A human colorectal cancer xenograft model with DLD-1 cancer cells was produced in the r

Objective: To analyze patterns of abdominopelvic failures and to define subgroups for the use of adjuvant radiotherapy in the International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian cancer (EOC). Methods: We reviewed 149 patients treated with debulking surgery followed by intravenous taxane and platinum chemotherapy between 1999 and 2008. Patient characteristics, patterns of failure, abdominopelvic failure APF-free survival (APFFS) and overall survival (OS) were

PurposeThe aim of this study was to examine the clinical implications of a pathologically completeresponse after neoadjuvant chemoradiotherapy (CRT) followed by local excisionfor patients with cT2 rectal cancer who refused radical surgery. Materials and MethodsSeventeen patients with cT2 primary rectal cancer within 6 cm from the anal vergewho received neoadjuvant CRT and local excision because of patient refusal of radicalsurgery or poor performance status were included. Two patients had clinic

Purpose: To describe the early experience of analyzing variations and time trends in bladder volume of the rectal cancer patients who received bladder ultrasound scan. Materials and Methods: We identified 20 consecutive rectal cancer patients who received whole pelvic radiotherapy (RT) and bladder ultrasound scan between February and April 2012. Before simulation and during the entire course of treatment, patients were scanned with portable automated ultrasonic bladder scanner, 5 times consecuti

Purpose: Adjuvant radiotherapy (RT) has been performed to reduce locoregional failure (LRF) following radical cystectomy for locally advanced bladder cancer; however, its efficacy has not been well established. We analyzed the locoregional recurrence patterns of post-radical cystectomy to identify patients who could benefit from adjuvant RT and determine the optimal target volume. Materials and Methods: We retrospectively reviewed 160 patients with stage ≥ pT3 bladder cancer who were treated wit

Purpose: Long-course chemoradiotherapy (LCRT) has been widely recommended in a majority of rectal cancer patients. Re cently, encouraging data on short-course radiotherapy (SCRT) for rectal cancer has emerged. In this study, we aimed to compare these two methods in terms of short-term outcomes and cost analysis under the Korean medical insurance system. Materials and Methods: Sixty-two patients with high-risk rectal cancer, who underwent either SCRT or LCRT followed by total mesorectal excision

Rectal resection surgery after neoadjuvant treatment has been the mainstay treatment of locally ad-vanced rectal cancer. However, functional outcomes and quality of life after radical resection of therectum remain suboptimal. The excellent oncologic outcomes in patients who achieved pathologiccomplete response after neoadjuvant treatment questioned the need for radical surgery. The watch-and-wait approach is a noninvasive therapeutic alternative for organ preservation and avoiding oper-ative mor

목 적: 방광압박도구(bladder compression device) 추가에 따른 벨리보드(belly board) 하위 경계의 위치 변화에 따라 조사체적(irradiated volume) 내의 각 장기의 체적 차이 및 선량체적히스토그람을 분석하여 벨리보드의 하위 경계의 위치가 미치는 영향에 대해 알아보고자 하였다. 대상 및 방법: 2010년 5월부터 2010년 9월까지 직장암으로 수술 전이나 후에 방사선치료를 위해 벨리보드만 사용하여 전산화 단층촬영을 시행한 경우와 방광압박도구를 추가하여 전산화 단층촬영을 재 시행한 10명을 대상으로 후향적으로 분석하였다. 환자의 중앙나이는 64세(범위, 45∼75세)로 조직학적으로 선암 진단을 받고, 수술 전 혹은 후에 동시항암화학방사선요법을 시행받았다. 방광압박도구 사용 전후 각 체적과 조사체적비의 평균비교 및 복강과 골반강의 조사체적의 합과 소장의 체적비와 방광의 체적비 간의 상관관계를 분석하였다. 결 과: 방광압박도구 추가 후 벨리보드 하위

Purpose We compared the local control rate and toxicity of stereotactic ablative radiotherapy (SABR) versus wedge resection for colorectal pulmonary metastases.Materials and Methods We retrospectively reviewed medical charts and imaging of patients treated with SABR or wedge resection between 2010 and 2017 at a single institution.Results A total of 404 patients were treated with local therapy for 528 pulmonary metastatic lesions. While surgery was frequently used upfront for smaller, solitary me

목적: 간세포암의 골전이가 증가됨에 따라 이에 대한 치료의 중요성이 증가되고 있으며 본 연구는 간세포암에서 유래한 골전이 환자에서 방사선치료의 통증 조절 효과에 대하여 분석하였다. 대상과 방법: 1991년 1월부터 2000년 6월까지 간세포암에서 유래한 골전이로 방사선치료를 받은 55명의 환자 중 계획된 방사선치료를 마친 51명(77 골전이 병소)을 대상으로 하였다. 대상환자 중 남자가 45명, 여자가 6명으로 남녀 비는 7.5 대 1 이었고 연령은 21세에서 80세였고 중앙값은 55세였다. 방사선치료는 하루 1회 선량 2.5 Gy에서 4 Gy로 총선량 12.5 Gy에서 50 Gy(중앙값 30 Gy)까지 시행되었다. 방사선치료에 대한 반응은 Wisconsin Brief Pain Questionnaire 검사로 분석하였으며 생존율 분석은 Kaplan- Meier법을 이용하였고 통계적 검증은 log rank test, Cox regression을 이용하였다. 결과: 원발 병소의 진단 당