심연희 교수

Purpose: We evaluated the incidence and risk factors of postoperative nausea and vomiting (PONV) in patients with fentanyl-based intravenous patient-controlled analgesia (IV-PCA) and single antiemetic prophylaxis of 5-hydroxytryptamine type 3 (5 HT3)-receptor antagonist after the general anesthesia. Materials and Methods: In this retrospective study, incidence and risk factors for PONV were evaluated with fentanyl IV-PCA during postoperative 48 hours after various surgeries. Results: Four hundre

This investigation evaluated the effect of continuous milrinone infusion on right ventriclular (RV) function during off-pump coronary artery bypass graft (OPCAB) surgery in patients with reduced RV function. Fifty patients scheduled for OPCAB, with thermodilution RV ejection fraction (RVEF) <35% after anesthesia induction, were randomly allocated to either milrinone (0.5 microgram/kg/min) or control (saline) group. Hemodynamic variables and RV volumetric data measured by thermodilution method we

Background: Rapid and complete reversal of neuromuscular blockade (NMB) is desirable at the end of surgery. Sugammadex reverses rocuronium-induced NMB by encapsulation. It is well tolerated in Caucasian patients, providing rapid reversal of moderate (reappearance of T2) rocuronium-induced NMB. We investigated the efficacy and safety of sugammadex versus neostigmine in Korean patients. Methods: This randomized, safety assessor-blinded trial (NCT01050543) included Korean patients undergoing genera

The CobraPLATM (CPLA) is a relatively new supraglottic airway device that has not been sufficiently investigated. Here, we performed a prospective observational study to evaluate the efficacy of the CPLA during controlled ventilation. In 50 anesthetized and paralyzed patients undergoing elective surgery a CPLA was inserted and inflated to an intracuff pressure of 60 cm H2O. The success rate of insertion upon the first attempt was 82% (41/50), with a mean insertion time of 16.3 4.5 seconds. The a

Background: Remifentanil has been shown to be effective at treating potentially adverse hemodynamic responses to tracheal intubation even at low doses (< 1 μg/kg/min), which needs to be evaluated in patients with diverse cardiovascular conditions. Methods: A low-dose regimen of remifentanil (continuous infusion of 0.1 μg/kg/min, preceded by 0.5 μg/kg bolus)was given before induction with bolus propofol and rocuronium, and heart rate as well as systolic, diastolic, and mean arterial pressures wer

배경: 심장박동 상태에서 시행하는 관상동맥우회술(Off pump coronary artery bypass grafting, OPCAB)은 심폐체외순환 하에서 시행하는 관상동맥우회술(On pump coronary artery bypass grafting, On pump CABG)에 비해 합병증이 다소 적은 것으로 보고되고 있다. 저자들은 좌심실 기능이 저하된 환자들에서 OPCAB과 On pump CABG의 단기 및 중기 성적을 평가하여 OPCAB의 유용성을 확인하였다. 대상 및 방법: 2001년 1월부터 2005년 2월까지 동반수술을 시행 받지 않고 관상동맥우회술만을 시행 받은 946명 중 좌심실 박출계수가 35% 이하인 100명을 대상으로 하였다(OPCAB군：On pump CABG군 =68명：32명). 평균 연령은 두 군이 OPCAB군과 On pump CABG군이 각각 62.9 9.0세와 63.8 8.0로 두 군의 차이가 없었다. 두 군의 수술 전 위험요인을 분석하고, 수술 결과 및

Opening of mitochondrial permeability transition pore (mPTP) was found to have a critical role in cell death from ischemia/reperfusion (I/R) injury experimentally in the late 1980’s. Thereafter, tremendous efforts have been made to define the molecular composition of mPTP and underlying mechanisms of its opening. mPTP opening, so far, has been demonstrated with the conformational changes of the mitochondrial protein components including cyclophilin-D, adenine nucleotide translocase, and voltage-

=Sedative Effect and Cardiovascular Stability of Lidocaine duringEndotracheal Intubation under Bispectral Index (BIS) MonitoringKyu Dae Shim, M.D., Jong Seok Lee, M.D., Yon Hee Shim, M.D.Jang-Hwan Jung, M.D., and Sang Beom Nam, M.D.

=Comparison between a Fentanyl and Clonidine Admixture to Lidocaine in a Brachial Plexus BlockKi-Young Lee, M.D., Kyu Dae Shim, M.D., Yon Hee Shim, M.D., Jeong-Sup Noh, M.D.Won Chul Kang, M.D., and Jong Seok Lee, M.D.

=Spinal and Supraspinal Changes in Vitamin D3 Up-regulated Protein 1 (VDUP1)Gene Expression after Spinal Cord InjuryYon Hee Shim, M.D., Young Ho Lee, M.D.*, Won Hyung Lee, M.D.†Seok Hwa Yon, M.D.†, and Yong Sup Shin, M.D.†ty College of Medicine, Seoul, Korea,

With an increase in the elderly population and an increase in the prevalence of age-related cardiovascular disease,anesthesiologists are increasingly being faced with elderly patients with known or suspected ischemic heart disease in the perioperative period. Although early reperfusion remains the best strategy to reduce ischemic injury, reperfusion may damage the myocardium. Adjuvant therapy to revascularization is therefore necessary. To develop better strategies to prevent ischemia-reperfusio

Aging is a process of the progressive functional decline with time, leading to disability, dependence, morbidity, and mortality. While the organ function in the elderly is relatively uncompromised under basal conditions, their ability to tolerate increased physiologic stress is reduced. And the extent and onset of the deterioration in functional reserve is quite diverse from patient to patient. The aging population is rapidly growing and their medical management is becoming one of the greatest c