박연정 교수

The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multiple organs and tissues in young and old (2-34 months) wild type (wt) mice was investigated by whole genome sequencing. Remarkably, no acquired somatic mutations were detected in tested tissues. Howeve

Despite the crucial physiological processes governed by neurons in the hypothalamic arcuate nucleus (ARC), such as growth, reproduction and energy homeostasis, the developmental pathways and regulators for ARC neurons remain understudied. Our single cell RNA-seq analyses of mouse embryonic ARC revealed many cell type-specific markers for developing ARC neurons. These markers include transcription factors whose expression is enriched in specific neuronal types and often depleted in other closely-

PRC2 creates the repressive mark histone H3 Lys27 trimethylation. Although PRC2 is involved in various biological processes, its role in glial development remains ambiguous. Here, we show that PRC2 is required for oligodendrocyte (OL) differentiation and myelination, but not for OL precursor formation. PRC2-deficient OL lineage cells differentiate into OL precursors, but they fail to trigger the molecular program for myelination, highlighting that PRC2 is essential for directing the differentiat

In humans, inactivating mutations in MLL4, which encodes a histone H3-lysine 4-methyltransferase, lead to Kabuki syndrome (KS). While dwarfism is a cardinal feature of KS, the underlying etiology remains unclear. Here we report that Mll4 regulates the development of growth hormone-releasing hormone (GHRH)-producing neurons in the mouse hypothalamus. Our two Mll4 mutant mouse models exhibit dwarfism phenotype and impairment of the developmental programs for GHRH-neurons. Our ChIP-seq analysis rev

Dimorphic Candida exist as commensal yeast carriages or infiltrate hyphae in the oral cavity. Here, we investigated the clinical relevance of Candida hyphae in non-pseudomembranous oral candidiasis (OC) by smears of tongue biofilms. We conducted a retrospective study of 2829 patients who had had tongue smears regardless of OC suspicion. Clinical characteristics were evaluated using a novel method of assessing hyphae. Clinical factors (moderate/severe stimulated pain, pain aggravated by stimulati

Regulation of the protein stability of epigenetic regulators remains ill-defined despite its potential applicability in epigenetic therapies. The histone H3-lysine 4-methyltransferase MLL4 is an epigenetic transcriptional coactivator that directs overnutrition-induced obesity and fatty liver formation, and Mll4+/- mice are resistant to both. Here we show that the E3 ubiquitin ligase UBE3A targets MLL4 for degradation, thereby suppressing high-fat diet (HFD)-induced expression of the hepatic stea

This study describes a method where the match of two different length scales, i.e., the patterns from self-assembled block copolymer (<50nm) and electron beam writing (>50nm), allow the nanometer scale pattern mask. The method is based on using block copolymers containing a poly(methyl methacrylate) (PMMA) block, which is subject to be decomposed under an electron beam, as a pattern resist for electron beam lithography. Electron beam on self assembled block copolymer thin film selectively etches

BACKGROUND: Non-dippers were reported as showing different left atrial function, compared to dippers, but no study to date investigated the changes in the left atrial function according to the diurnal blood pressure pattern, using tissue Doppler and strain imaging. METHODS: Forty never treated hypertensive patients between 30 and 80 years of age were enrolled in this study. Patients were classified as non-dippers when, during night time, they had a blood pressure decrease of less than 10%. Strai

The protocol FAST (FIX adapted for streaming) is superior than FIX in that it performs data compression according to the protocol template prescribed. Since the FAST protocol template captures the sequence characteristic of the transmitted data, it is written manually by human experts. This paper describes an algorithm for generating FAST protocol templates automatically by analyzing the patterns of message sequence. The experimental result shows that the proposed algorithm is slightly more effi

This study was designed to establish safe guidelines for pediatric dental practice regarding temporomandibular joint (TMJ) range of motion (ROM) and mouth area (MA). A total of 438 children aged 3–15 years old of homogenous ethnicity participated in the study; the distribution of participants was approximately equal (sex; n = 15; age, n = 30). Maximum mouth opening (MMO), body height, weight, and age of each participant were recorded, and the TMJ ROM including anterior and lateral movements, MA,

(1) Background: Botulinum toxin (BoNT) injection is an esthetically effective and safe treatment for contouring the lower face. This study aimed to evaluate the combined effects of BoNT and supplementary oral appliance (OA) therapy on lower facial contouring. (2) Methods: We conducted a prospective randomized controlled trial from January 2015 to June 2016 at the Yonsei University Dental Hospital. Volunteers aged 20−45 years with masseter hypertrophy were randomly assigned to one of two groups:

본 연구에서는 적외선 윈도우의 냉각을 위해 포펫 밸브와 방사형 오리피스로 구성된 냉각장치 유로를 설계하였다. 필요한 냉각제의 양은 운용조건에 따라 달라지므로 포펫 행정거리에 따른 유동장의 유량과 윈도우 전후단 압력 변화를 유동해석을 통해 예측하고 실험을 통해 이를 확인하였다. 설계된 포펫과 방사형 오리피스 유로는 윈도우 냉각에 필요한 유량을 공급하며 윈도우 구조 강도를 만족하도록 내부 압력을 낮추고 적외선 이미지 신호의 왜곡이 없도록 아음속으로 유지하여 요구 조건을 충족시켰다. 실험으로 측정된 유량을 이용하여 윈도우에서의 송출계수와 2차원 해석결과 사이의 보정계수를 확인하였으며 이를 냉각장치의 유량제어에 사용하였다. This paper presents the flow passage design for a window cooling device, which have a conical poppet valve and an emissive orifice. Computational flow

[목적] 본 연구는 보편적 학습설계(Universal Design for Learning: UDL)를 적용한 국내 중재연구를 분석하여 실제 교실 수업에서 적용하는 데에 도움이 되도록 자료를 제공하는 것에 목적을 두었다. [방법] 첫째, UDL을 적용한 중재연구 15편을 연구의 일반적인 특성을 파악하기 위한 틀에 따라 하위 8가지로 코딩하여 분석하였다. 둘째, 중재연구 15편을 UDL의 지침 요소를 적용한 틀에 따라 하위 9가지로 코딩하여 분석하였다. [결과] 첫째, UDL을 적용한 중재연구의 일반적인 특성을 분석한 결과, 대부분의 연구가 통합교육 배치 환경에서 적용되었으며, 고등학생을 대상으로 이루어진 연구는 제한적임을 알 수 있었다. 또한, 국어, 사회, 과학, 미술, 체육 교과에서 UDL을 적용하여 비교적 다양한 교과에서 관련 연구가 이루어졌다. 지적장애 학생을 대상으로 한 연구 및 실험/통제집단 사전-사후 검사가 가장 많이 발표되었으며, UDL을 적용한 수업이 다양한 학습자들의