김용진 교수

본 연구는 노인의 신체적 활동 및 사회적 활동을 장려하며, 나아가 노인의 건강과 정신적 건강을 제고할 수 있는 물리적 환경을 분석하는데 그 목적이 있다. 본 연구의 방법은 설문조사 및 구조방정식모형을 활용한 통계분석이다. 설문조사는 서울의 종로구, 동작구, 구로구, 광진구, 강서구에 거주하는 60세 이상 노인들을 대상으로 하여 총 500명을 대상으로 일대일 면접조사를 실시하였으며, 설문응답자의 주소를 중심으로 반경 500m의 물리적 환경과 이들의 사회적 활동, 신체건강 및 정신건강의 관계를 구조방정식 모델을 이용하여 분석하였다. 분석 결과, 근린의 물리적 환경이 노인의 신체적 활동을 장려하는 역할을 할 수 있음을 확인하였으며, 나아가 이러한 신체적 활동이 노인의 건강 상태를 제고할 수 있는 것으로 나타났다. 우선, 근린의 보행환경이 양호한 곳에서 노인들의 경로당 및 복지관 이용과 같은 표현활동이 장려되었으며, 동창회나 향우회와 같은 지역 기반의 연고집단활동이 장려되었다. 반면, 대중

STUDY QUESTION: Do microRNAs (miRNAs) in granulosa cells (GCs) affect oocyte maturation during ovarian follicle development? SUMMARY ANSWER: Sophisticated regulation by miRNAs in ovarian GCs may improve oocyte maturation efficiency during ovarian follicle development. WHAT IS KNOWN ALREADY: The meiotic competence of oocytes depends on the follicle's potential to undergo appropriate maturation and is an important factor in infertility therapies such as IVF. The exact function of the GCs during fo

Sex steroids influence the maintenance and growth of muscles. Decline in androgens, estrogens and progesterone by aging leads to the loss of muscular function and mass, sarcopenia. These steroid hormones can interact with different signaling pathways through their receptors. To date, sex steroid hormone receptors and their exact roles are not completely defined in skeletal and smooth muscles. Although numerous studies focused on the effects of sex steroid hormones on different types of cells, st

OBJECTIVE: Glutaraldehdye (GA)-fixed xenografts are widely used in cardiovascular surgery. The objective of this study was to evaluate the anticalcification effect of glycine treatment and high-concentration GA fixation in organic solvent on GA-fixed bovine pericardium, and to evaluate the possible synergistic effect of combined treatment. METHODS: Bovine pericardial tissues were divided into four groups according to the methods of treatment. Group 1 consisted of tissues fixed with 0.5% GA (cont

본 연구는 국내 도시열섬현상이 기후변화에 따라 그 특성이 변화하고 있다는데 주목하여, 해외와는 차별화된 대안을 찾는데 그 목적이 있다. 우선, 국내의 도시열섬현상은 맑은 날에 주로 발생하는 해외 많은 도시들과는 달리, 고온다습한 북태평양기단의 영향으로 일사가 상당량 차단된 흐린 날에도 발생하는 특징을 보였다. 특히, 최근에는 기후변화로 인해 장마철이 점차 짧아지고 집중호우가 더 자주 발생하면서 고온다습한 흐린 날이 늘어나 이러한 현상을 심화시키고 있다. 이에 본 연구에서는 서울시 31개 지점의 자동기상관측(AWS)자료를 활용하여 맑은 날과 흐린 날의 도시열섬현상의 요인에 대해 분석하였다. 분석 결과, 맑은 날의 도시열섬현상은 고도, 풍속, 녹지면적이 도시열섬현상 발생의 주요한 요인으로 나타났다. 그러나 흐린 날의 도시열섬현상은 건물의 종횡비가 주요한 요인으로 나타나 복사열에 의해 도시열섬현상이 심화되고 있는 것으로 나타났다. 따라서 국내 도시열섬현상 저감을 위해서는 주차장 및 건물의

OBJECTIVES: There is no consensus on whether restarting TNF inhibitors (TNFis) after treatment of an active tuberculosis (TB) infection caused by previous TNFi exposure is safe. In this study we sought to determine the safety of resuming TNFis in patients following TB treatment. METHODS: The medical records of all patients (n = 683) that received TNFi treatment at a single rheumatology clinic between June 2003 and December 2012 were retrospectively reviewed. Among them, data from patients who de

Magnetic skyrmions are stable spin textures with quasi-particle behavior and attract significant interest in fundamental and applied physics. The metastability of magnetic skyrmions at zero magnetic field is particularly important to enable, for instance, a skyrmion racetrack memory. Here, the results of the nucleation of stable skyrmions and formation of ordered skyrmion lattices by magnetic force microscopy in (Pt/CoFeSiB/W)n multilayers, exploiting the additive effect of the interfacial Dzyal

Abstract The spin–orbit torque (SOT) resulting from a spin current generated in a nonmagnetic transition metal layer offers a promising magnetization switching mechanism for spintronic devices. To fully exploit this mechanism, in practice, materials with high SOT efficiencies are indispensable. Moreover, new materials need to be compatible with semiconductor processing. This study introduces W–Ta and W–V alloy layers between nonmagnetic β-W and ferromagnetic CoFeB layers in β-W/CoFeB/MgO/Ta hete

Intrauterine insemination (IUI) is a widely used fertility treatment for couples with male and/or non-male factor infertility and is a relatively simple and inexpensive procedure. When used for unexplained infertility, IUI combined with ovarian stimulation increases the pregnancy rates, but evidence does not support this to be true when applied for male factor infertility. Recently, the revised World Health Organization laboratory manual for semen criteria provided a new insight for practical gu

The expression profile of microRNA (miRNA) in uterine leiomyoma (UL) cells is different from that in normal uterine myometrial (UM) cells. The effect of UL cells on uterine receptivity might vary according to their ability to distort the uterine endometrial cavity. However, the variation in miRNA expression profiles between endometrial cavity-distorting leiomyoma (ECDL) and endometrial cavity non-distorting leiomyoma (ECNDL) cells remains unknown. This study aimed to elucidate whether the expres

In vitro culture of ovarian follicles is a promising bioengineering technique for retrieving fertilizable oocytes from preserved ovarian tissues of cancer survivors. However, current in vitro follicle culture techniques are labour-intensive and of low efficiency, as only single follicle culture (SFC) has been possible to date. The present study investigated the feasibility of multifollicular cluster culture (MFCC) system using angiotensin II receptor (ATII-Rc) analogues. Ovarian pre-antral folli