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이용석 교수

Yong-Seok Lee

서울대학교 생리학과 · 의학

연구실 소개

이용석 교수의 연구실은 곤충의 면역 반응과 생체 내 신호 전달 메커니즘을 중심으로, 페놀옥시다제 활성화를 통한 멜라니제이션 반응 조절, TLR2 수용체를 통한 병원성 박테리아 인식, 그리고 고온 환경에서 기능하는 전사 활성화 단백질의 구조 기반 기전 규명 등 생물의 고전적 면역 시스템과 신호 전달 경로의 분자 기전을 연구하고 있습니다. 특히, 곤충의 비특이적 면역 반응에서 핵심적인 역할을 하는 프로페놀옥시다제 활성화 경로와 그 조절 메커니즘을 생화학적·저해상도 구조 생물학적 접근으로 규명하고 있습니다. 이와 더불어, 병원성 박테리아의 리포프로테인을 통해 TLR2를 활성화하는 메커니즘을 정량적 분석을 통해 규명하고 있습니다.

멜라니제이션 반응TLR2 활성화프로페놀옥시다제신호 전달 경로구조 생물학

연구 현황

논문 수
139
총 인용 수
2,317
최근 5년 논문
20
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
20총합
2022
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2026
5개년 연도별 피인용 수
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주요 논문

15
1
논문|인용수 84·2021
High triglyceride-glucose index is associated with early recurrent ischemic lesion in acute ischemic stroke
Ki‐Woong Nam, Hyung‐Min Kwon, Yong-Seok Lee
SJR Q1Scientific ReportsOA

The triglyceride-glucose (TyG) index has been associated with various metabolic, cardiovascular, and cerebrovascular diseases. We evaluated the association between the TyG index and early recurrent ischemic lesions (ERILs) in patients with acute ischemic stroke (AIS). We included consecutive patients diagnosed with AIS between 2010 and 2016. ERILs were defined as new diffusion-weighted imaging lesions outside the initial symptomatic lesion area. The TyG index was calculated using the following f

Pulmonary and Respiratory MedicineMedicine
2
논문|인용수 81·2011
Cilostazol in Acute Ischemic Stroke Treatment (CAIST Trial): A Randomized Double-Blind Non-Inferiority Trial
Yong-Seok Lee, Hee‐Joon Bae, Dong‐Wha Kang, Seung‐Hoon Lee, Kyungho Yu, Jong‐Moo Park, Yong‐Jin Cho, Keun‐Sik Hong, Dong‐Eog Kim, Sun U. Kwon, Kyung Bok Lee, Joung‐Ho Rha
SJR Q2Cerebrovascular Diseases

BACKGROUND: Aspirin is a proven antiplatelet agent in acute ischemic stroke, and there are no current guidelines for other antiplatelet treatments. We aimed to compare the efficacy and safety of cilostazol with aspirin in acute stroke. METHODS: Patients with measurable neurological deficits (NIHSS score ≤15) within 48 h of onset were randomly assigned to cilostazol (200 mg/day) or aspirin (300 mg/day) for 90 days. The primary endpoint was a modified Rankin Scale (mRS) score of 0-2 at 90 days. Ca

Cardiology and Cardiovascular MedicineMedicine
3
논문|인용수 54·2015
Cerebral Microbleeds and Early Recurrent Stroke After Transient Ischemic Attack
Jae‐Sung Lim, Keun‐Sik Hong, Gyeong‐Moon Kim, Oh Young Bang, Hee‐Joon Bae, Hyung‐Min Kwon, Jong‐Moo Park, Seung‐Hoon Lee, Joung‐Ho Rha, Jaseong Koo, Kyung‐Ho Yu, Woo‐Keun Seo
SJR Q1JAMA Neurology

Immediate and optimal management seems to modify the risk of recurrent stroke after TIA. Cerebral microbleeds may be novel predictors of stroke recurrence, which needs further validation.

NeurologyMedicine
4
논문|인용수 47·2011
Hypertriglyceridemia as a possible predictor of early neurological deterioration in acute lacunar stroke
Hyung‐Min Kwon, Jae‐Sung Lim, Hong‐Kyun Park, Yong-Seok Lee
SJR Q1Journal of the Neurological Sciences
EpidemiologyMedicine
5
논문|인용수 41·2007
Transcranial Doppler ultrasonographic evaluation of vertebral artery hypoplasia and aplasia
Ju‐Hong Min, Yong-Seok Lee
SJR Q1Journal of the Neurological Sciences
SurgeryMedicine
6
논문|인용수 27·2017
Leukoaraiosis is associated with pneumonia after acute ischemic stroke
Ki‐Woong Nam, Hyung‐Min Kwon, Jae‐Sung Lim, Yong-Seok Lee
SJR Q2BMC NeurologyOA

BACKGROUND: Stroke-associated pneumonia (SAP) is common in patients with acute ischemic stroke, and several risk factors have been reported. However, the relationship between underlying leukoaraiosis (LA) and SAP has not been addressed. METHODS: We collected consecutive patients with acute ischemic stroke within 24 h of symptom onset. SAP was defined as the lower respiratory tract infection within the first 7 days after stroke onset, according to the modified Centers for Disease Control and Prev

EpidemiologyMedicine
7
논문|인용수 26·2023
Clinical significance of D-dimer levels during acute period in ischemic stroke
Ki‐Woong Nam, Hyung‐Min Kwon, Yong-Seok Lee
SJR Q2Thrombosis JournalOA

BACKGROUND: Initial D-dimer level is a well-known prognostic parameter in patients with acute ischemic stroke (AIS). However, there have been no studies on the clinical significance of follow-up D-dimer levels. In this study, we evaluated the association between initial and follow-up D-dimer levels and early neurological deterioration (END) in patients with AIS. METHODS: We included consecutive patients with AIS who had a positive initial D-dimer test (> 0.55 mg/L) between March 2021 and Novembe

Internal MedicineMedicine
8
논문|인용수 25·2020
Distinct association between cerebral arterial pulsatility and subtypes of cerebral small vessel disease
Ki‐Woong Nam, Hyung‐Min Kwon, Yong-Seok Lee
SJR Q1PLoS ONEOA

Ipsilateral PI is closely associated with cSVD in patients with lacunar stroke. Furthermore, this association is different between subtypes of cSVD, which is suggestive of underlying pathophysiological differences.

NeurologyMedicine
9
논문|인용수 24·2021
Effect of obstructive sleep apnea on cerebrovascular compliance and cerebral small vessel disease
Woo‐Jin Lee, Keun‐Hwa Jung, Hyunwoo Nam, Yong-Seok Lee
SJR Q1PLoS ONEOA

Reduced cerebrovascular compliance is the major mechanism of cerebral small vessel disease (SVD). Obstructive sleep apnea (OSA) also promotes SVD development, but the underlying mechanism was not elucidated. We investigated the association among OSA, cerebrovascular compliance, and SVD parameters. This study retrospectively included individuals ≥ 50 years of age, underwent overnight polysomnographic (PSG) for the evaluation of OSA, and performed MRI and transcranial Doppler (TCD) within 12 month

PhysiologyMedicine
10
논문|인용수 24·2017
The correlation between cerebral arterial pulsatility and cognitive dysfunction in Alzheimer's disease patients
Jae‐Sung Lim, Jee‐Young Lee, Hyung‐Min Kwon, Yong-Seok Lee
SJR Q1Journal of the Neurological Sciences
Pulmonary and Respiratory MedicineMedicine
11
논문|인용수 22·1999
Neuroprotective effects of lamotrigine enhanced by flunarizine in gerbil global ischemia
Yong-Seok Lee, Byung‐Woo Yoon, Jae‐Kyu Roh
SJR Q2Neuroscience Letters
Psychiatry and Mental healthMedicine
12
논문|인용수 15·2005
Transcranial Doppler sonography evaluation of anterior cerebral artery hypoplasia or aplasia
Hyung‐Min Kwon, Yong-Seok Lee
SJR Q1Journal of the Neurological Sciences
Pulmonary and Respiratory MedicineMedicine
13
논문|인용수 5·2017
대학 영어 전공강의 수강이 대학생들의 학업적 자기효능감과 영어의사소통 자아개념에 미치는 영향
이용석

본 연구에서는 한국교육개발원의 한국교육종단연구 7, 8차년도 데이터를 사용하여 대학교 영어 전공강의가 학생들 의 학업 자기효능감 및 영어 의사소통 자아개념에 미치는 효과를 분석하였다. 우선, 영어전공강의의 선택에 영향을 미치는 요인을 분석하였고, 이를 토대로 경향점수매칭(Propensity Score Matching) 방식을 적용하였다. 추가로, Rosenbaum Bounds와 Mantel-Haenszel Bounds 같은 민감도 분석(Sensitivity Analysis)을 실시하여 비관측 외부요인의 영향력을 확인하였다. 분석 결 과, 영어 전공강의 선택에 있어 전년도 영어강의 수강학점 및 수능 외국어영역 점수, 학업자아개념이 중요한 요인으로 작용 하였으며, 선택편의 조정 이후, 영어 전공강의가 관심 종속변수에 갖는 처치효과의 유의성은 상실되었다. 민감도 분석 결과, 영어 전공강의의 효과는 관찰되지 않은 외부변인의 영향력으로부터 강건하다고 나타났다. 일련의 결과를 바탕으로 대학에서

14
논문|인용수 4·2010
The Linguistic Validation and Reliability of the Korean Version 'Qualiveen Questionnaire'
Yong-Seok Lee, Eunsoo Kim, Seung‐June Oh, Bum-Suk Lee, Dong-A Kim
SJR Q1Annals of Rehabilitation MedicineOA

Objective: To translate the English Qualiveen questionnaire which was developed to measure the specific impact of urinary problems on the quality of life of patients with neurogenic bladder into Korean and validate it. Method: First, we made the Korean version Qualiveen questionnaire through translation and cross-cultural adaptation followed by the international guideline. This process consisted of 6 steps including translation, reconciliation, back translation into English and debriefing. And t

RheumatologyMedicine
15
논문|인용수 3·2003
Nonpulsatile Cerebral Perfusion in Takayasu’s Arteritis
Yong-Seok Lee, Byung‐Woo Yoon, Jae‐Kyu Roh
SJR Q1Journal of Neuroimaging
Pulmonary and Respiratory MedicineMedicine

대표 연구 분야

Pulmonary and Respiratory MedicineEpidemiologyCardiology and Cardiovascular MedicineNeurologyRehabilitationRadiology, Nuclear Medicine and Imaging

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