김윤정 교수

Peroxiredoxin 1 (Prx1) has been found to be elevated in several human cancers. The cell survival-enhancing function of Prx1 is traditionally attributed to its reactive oxygen species-removing capacity, although the growth-promoting role of Prx1 independent of this antioxidant activity is increasingly gaining attention. Although much progress has been made in understanding the behavior of Prx1, little information is available on the mechanism responsible for the abnormal elevation of Prx1 level i

Radiotherapy is one of the major treatment modalities for lung cancer. Cell killing by ionizing radiation is mediated primarily through the reactive oxygen species (ROS) and ROS-driven oxidative stress. Prx1, a peroxiredoxin family member, was shown to be frequently elevated in lung cancer cells and tissues. Although the antioxidant function of Prx1 is expected to affect the radiotherapy response of lung cancer, the physiologic significance of its peroxidase activity in irradiated cells is uncle

Purpose: Identification of tolerable alternative analgesics is crucial for management in nonsteroidal anti-inflammatory drug (NSAID)-sensitive patients. We investigated cross-reactivity of acetaminophen and celecoxib according to the type of aspirin/NSAID hypersensitivity and aimed to determinethe risk factors for cross-intolerance. Methods: We retrospectively reviewed the medical records of patients intolerant to aspirin and NSAIDswho had undergone an acetaminophen and/or celecoxib oral provoca

본 연구는 식사의 질이 떨어지는 12~24개월 영유아의기질과 식행동, 어머니의 식행동과 식사지도방법의 특성을분석하였으며 그 결과를 요약하면 다음과 같다. 1) 조사 대상자의 남녀 분포는 PE 집단의 경우 남자42.3%, 여자 57.7%, NC 집단은 남자 58.5%, 여자 41.5% 로 유의적인 차이는 없었다. 어머니의 교육수준, 가족의 월수입과 아버지의 직업의 경우 두 집단간 유의적인 차이는없었으며, 아버지의 직업은 두 집단 모두‘사무직 또는 전문직’이 높았고(PE, 66.7%; NC, 69.8%), 어머니는‘직업이 없다’가 높은 경향을 보였다(PE, 77.8%; NC, 77.4%). 나이에 따른 신장과 체중의 Z-score는 두 그룹간 차이는없었으며, 모두 정상범위였다(-1 ≤ Z-score ≤ 1). 2) 영유아의 식사 도구 시작 시기는 컵의 경우는 PE 집단은 9.9개월, NC 집단은 9.5개월, 빨대의 경우는 PE 집단은 10.2개월, NC 집단은 10.1개월, 숟가락의 경

Base excision repair (BER) is an evolutionarily conserved pathway, which could be considered the “workhorse” repair mechanism of the cell. In particular, BER corrects most forms of spontaneous hydrolytic decay products in DNA, as well as everyday oxidative and alkylative modifications to bases or the sugar phosphate backbone. The repair response involves five key enzymatic steps that aim to remove the initial DNA lesion and restore the genetic material back to its original state: (i) excision of

This study investigates how the physical attractiveness of salespeople and other customers and self-imagecongruence influence customer perception and brand attitude. As a result of a pretest, four types of pictorialstimuli were developed: physical attractiveness of salespeople (high/low) × that of other customers (high/low). Stimuli were developed using Photoshop CS. A total of 550 samples in two experiments were usedand all respondents were women in their 20s and 30s. Data were analyzed using A

Genetic alterations have been reported for decades in most human embryonic stem cells (hESCs). Survival advantage, a typical trait acquired during long-term in vitro culture, results from the induction of BCL2L1 upon frequent copy number variation (CNV) at locus 20q11.21 and is one of the strongest candidates associated with genetic alterations that occur via escape from mitotic stress. However, the underlying mechanisms for BCL2L1 induction remain unknown. Furthermore, abnormal mitosis and the

tHE PURPOSE OF THIS STUDY WAS TO DETERMINE THE CHARACTERISTICS OF INFANTS’ TEMPERAMENTS, MATERNAL FEEDING BEHAVIORS AND FEEDING PRACTICES IN PICKY EATERS. PARTICIPANTS WERE 83 INFANTS (AGED 12 - 24 MONTHS) FROM “a” HOSPITAL (sEOUL)AND “b” PUBLIC HEALTH CENTER (KYUNGGIDO). mOTHERS COMPLETED QUESTIONNAIRES THAT ASSESSED THEIR OWN FEEDING BEHAVIOR,FEEDING PRACTICES, INFANTS’ TEMPERAMENT AND INFANTS’ FEEDING BEHAVIOR. PICKY EATERS’ DEMOGRAPHICS WERE NOT SIGNIFICANTLY DIFFERENT FROM NON-PICKY EATERS

This research analyzed characteristic changes in trading areas and the success factors of popular fashion trading areas (Garosu-gil, Dongdaemun, and Itaewon). This research adopts a social network analysis method to semantically analyze trading areas. Articles on the three fashion trading areas were located through KrKwic software to extract keywords and calculate word frequency. Keywords with high frequency were placed through NodeXL software to identify relationships among keywords. Researcher

Peroxiredoxin 1 (Prx1) is frequently elevated in human cancer. Although the cell survival enhancing function of Prx1 has traditionally been attributed to its antioxidant activity, the growth promoting role of Prx1 independent of its antioxidant activity is increasingly gaining attention. Prx1 interacts with and modulates the activities of growth regulatory proteins in a fashion favoring cell survival. The human Prx1 promoter was recently cloned and characterized. It was found that hypoxia/reoxyg

With the pervasiveness of digital environment and expansion of new media, ICT (Information and Communication Technology) leads the role of consumer to change from a passive customer into an active co-producer. As customer participation in the fashion industry increases, this study attempts to explore the cases of customer participation as a co-producer in fashion industry through analyzing business models of companies, including Threadless, Blank label, Cut on Your Bias, Acustom Apparel, Thinkgi

Deregulation of crucial embryonic pathways, including hedgehog signaling, has been frequently implicated in a variety of human cancers and is emerging as an important target for anticancer therapy. This study evaluated the potential anticancer effects of cyclopamine, a chemical inhibitor of hedgehog signaling, in human malignant mesothelioma (HMM) cell lines. Cyclopamine treatment significantly decreased the proliferation of HMM cells by promoting apoptosis and shifting the cell cycle toward dor

Sorafenib (BAY 43–9006) was developed as a multi-kinase inhibitor to treat advanced renal cell, hepatocellular, and thyroid cancers. The cytotoxic effect of sorafenib on cancer cells results from not only inhibiting the MEK/ERK signaling pathway (the on-target effect) but also inducing oxidative damage (the off-target effect). The inhibitory effect of sorafenib on system Xc- (xCT), a cystine/glutamate antiporter, promotes ferroptosis induction and accounts for oxidative damage. While emerging st

The Meaning of Vengeance in Park, Chan-wook's Vengeance Trilogy Kim, Yun-jeongThis paper examined the plot and subject in Park, Chan-wook's vengeance trilogy. The plot of Vengeance is one of those that have been mostly dealt with in human history, for the feeling of vengeance is common and easy to response to mankind. Whenever the story is based on vengeance, it usually becomes strong emotionally. While in reality it is impossible to avenge someone personally because of the limits set by the law