김영아 교수

Abstract Anaplastic thyroid cancer (ATC) and advanced differentiated thyroid cancers (DTCs) show fatal outcomes, unlike DTCs. Here, we demonstrate mutational landscape of 27 ATCs and 86 advanced DTCs by massively-parallel DNA sequencing, and transcriptome of 13 ATCs and 12 advanced DTCs were profiled by RNA sequencing. TERT , AKT1 , PIK3CA , and EIF1AX were frequently co-mutated with driver genes ( BRAF V600E and RAS ) in advanced DTCs as well as ATC, but tumor suppressors (e.g., TP53 and CDKN2A

Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.

Abstract Purpose: To determine the prognostic roles of breast cancer subtypes in females with operable invasive breast cancer. Experimental Design: Data of 321,958 patients from Surveillance, Epidemiology, and End Results (SEER) database were analyzed. Breast cancer subtypes were classified into four categories according to the status of hormone receptor (HRc) and HER2: HRc(+)/HER2(−), HRc(+)/HER2(+), HRc(−)/HER2(+), and HRc(−)/HER2(−). Results: Proportions of HRc(+)/HER2(−), HRc(+)/HER2(+), HRc

The kinase Aurora B forms the chromosomal passenger complex (CPC) together with Borealin, INCENP, and Survivin to mediate chromosome condensation, the correction of erroneous spindle-kinetochore attachments, and cytokinesis. Phosphorylation of histone H3 Thr3 by Haspin kinase and of histone H2A Thr120 by Bub1 concentrates the CPC at the centromere. However, how the CPC is recruited to chromosome arms upon mitotic entry is unknown. Here, we show that asymmetric dimethylation at Arg2 on histone H3

In this paper, the impact damage behavior of USN-150B carbon/epoxy composite laminates subjected to high velocity impact was studied experimentally and numerically. Square composite laminates stacked with <TEX>$[45/0/-45/90]_{ns}$</TEX> quasi-symmetric and <TEX>$[0/90]_{ns}$</TEX> cross-ply stacking sequences and a conical shape projectile with steel core, copper skin and lead filler were considered. First high-velocity impact tests were conducted under various test conditions. Three tests were

Our findings suggest that survivin overexpression may be related to the pathogenesis of AC and can be a predictor of disease progression. COX-2 may be involved in the early phase of thyroid carcinoma.

Curcuma alismatifolia 'Chiangmai Pink'의 화아발달 과정을 SEM을 통해 관찰하였다. 쿠르쿠마 근경에서 자란 맹아의 발육정도에 따른 화아분화 과정과 단계별 화아분화의 형태적 특성은 정식 후 식물체의 싹이 15-20cm 가량 자랐을때 생장점의 중앙부가 돔형으로 비대되는 경정분열조직에서 포엽이 분화되기 시작하였다. 포엽이 5-7매 가량 분화되면 포엽과 포엽 사이에서 화아가 형성되기 시작하였고, 보통 포엽당 화아는 4-6개가 관찰되었다. 화아가 분화되는 순서는 맨 하위 포엽 내 존재하는 것부터 상부로 올라가면서 하나씩 분화되었고 상부의 것이 분화되면 다시 하부의 4-6개의 화아 중 또 다른 화아가 상부쪽으로 향하면서 하나씩 순차적으로 되었다. Curcuma alismatifolia is becoming popular for cut flowers and potted plants due to its long inflorescence with many showy p

4874 Extranodal NK/T-cell lymphoma is more common among Orientals and recognized as a distinctive clinicopathologic entity. This lymphoma shows a highly aggressive clinical course and development of an effective chemotherapeutic modality is strongly advocated. Hank-1 is an NK/T-cell lymphoma cell line, which is derived from nasal type NK/T-cell lymphoma and a good candidate for the study of molecular characteristics of NK/T-cell lymphomas. Genistein is a major isoflavone of soybeans and has been

To investigate the differences of anatomical structure of neck tissue between bent-neck and strong-neck flowers, scanning electron microscopy of neck tissue during senescence of cut rose flowers held in deionized water or preservative solution (3% sucrose + 200 ppm HQS + 0.1 mM ethionine) was observed. Lignins in xylem, phloem, and interfascicular cambium of neck were stained to red by phloroglucine. More lignin was formed in the phloem of neck in rose flowers held in preservative solution than

Kim, Young A, Sim, Chung Ja (2021): Ten new species of families Suberitidae and Polymastiidae (Demospongia: Heteroscleromorpha) from Korea. Journal of Species Research 10 (2): 168-183, DOI: 10.12651/JSR.2021.10.2.168

The association of simian virus 40 (SV40) with certain types of human cancers, including malignant lymphomas, has been a topic of interest for some time. Although the virus is distributed worldwide, its incidences vary according to the specific types of tumors, and the epidemiological areas. The aim of this study was to investigate the frequency of SV40 in malignant lymphomas among Korean patients. Methods : One hundred seventy three cases of malignant lymphomas were evaluated by immunohistochem