유영훈 교수

Purpose: We investigated the feasibility of preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) radiomics with machine learning to predict microsatellite instability (MSI) status in colorectal can cer (CRC) patients. Materials and Methods: Altogether, 233 patients with CRC who underwent preoperative FDG PET/CT were enrolled and divided into training (n=139) and test (n=94) sets. A PET-based radiomics signature (rad_score) was established to predi

In recent years, several radiotracers that selectively bind to pathological tau proteins have been developed. Evidence is emerging that binding patterns of in vivo tau positron emission tomography (PET) studies in Alzheimer’s disease (AD) patients closely resemble the distribution patterns of known neurofibrillary tangle pathology, with the extent of tracer binding reflecting the clinical and pathological progression of AD. In Lewy body diseases (LBD), tau PET imaging has clearly revealed cortic

18F-AV-1451 is a tau PET ligand that has high affinity for paired helical filament tau. However, various off-target bindings unrelatedto tau have also been reported. Herein, we report a case of 83-year-old woman, who showed abnormal uptake of AV-1451 thatwas shown to be subacute infarction. Clinicians should recognize that increased uptake of AV-1451 may be related to stroke.

e22071 Background: High rate of glycolysis exhibited by cancer cells plays a crucial role in carcinogenesis and tumor progression. We sought to uncover key molecules contributing to increasing glucose uptake identified by 18F-fluorodeoxy glucose positron emission tomography (FDG-PET), along with an exploration its prognostic value using two breast cancer cohorts. Methods: First cohort consisted of 66 women with FDG-PET and gene-expression profiling (Illumina, San Diego, CA). Clustered analysis b

e12005 Background: [ 18 F] fluorodeoxyglucose positron emission tomography (18F-FDG–PET) scans are known as an important imaging study with their reflection biological activity in various malignancies. To investigate clinical impact of 18F-FDG–PET in breast cancer, we performed survival analysis with maximum standardized uptake values (SUV max ), and compared SUV max according to breast cancer subtypes. Methods: We reviewed the medical records of 462 patients with breast cancer who underwent pri

Background: Overlapping clinical features of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA) make it difficult to conduct an accurate differential diagnosis. We performed a quantitative F18- fluorodeoxyglucose PET (FDG PET) and measured the striatal and cerebellar glucose metabolism to evaluate the efficacy of a FDG PET study in the differential diagnosis between IPD and MSA. Methods: This study included 19 patients with IPD, 28 patients with MSA (MSA-P:MSA-C=19:9) and 12

목 적：methylphenidate(MP)는 ADHD에서 효과적인 치료제이며 70%의 환자가 MP에 좋은 치료반응을 보인다. 본 연구는 ADHD 아동에서 약물의 주 작용부위이자 도파민 체계에서 중요한 조절자인 기저신경절 Dopamine Transporter(DAT) 밀도가 MP 치료반응을 예측할 수 있는지에 대해 알아보고자 한다. 방 법：연세대학교 의과대학 정신과 영동 세브란스 병원 소아 청소년 정신과를 내원한 6~12세 ADHD 남아 15명을 대상으로 한다. 이중 MP에 대한 반응군은 8명이며 비반응군은 7명이었다. 이들에게 약물치료 전 임상평가와 함께 [123I]IPT SPECT를 시행하였다. MP 투홍현주 등 385 여 8주 후 다시 치료반응을 평가하며 MP 반응군과 비반응군 사이의 기저핵 DAT 밀도의 차이를 알아보았다. 또한 DAT 밀도에 영향을 미치는 다른 인자와 치료반응을 예측하는 다른 인자들도 알아보았다. 결 과：MP반응군과 비반응군 사이에는 기저신경절 DAT 농도차이

목 적 : 주의력결핍 과잉행동장애(Attention Deficit Hyperactivity Disorder ; 이하 ADHD)는 도파민계와 관련있는 것으로 알려져 있는 대표적 소아 정신과적 장애이며, 특히 도파민 운반체(dopamine transporter ; 이하 DAT) 유전자와의 연관성은 널리 입증되어있다. 따라서 본 연구에서는 최근 I-123 IPT를 이용한 SPECT 영상으로 기저 신경절의 DAT 밀도를 측정하여, ADHD 환아에서의 도파민계의 비정상적 소견을 알아보고자 하였다. 방 법 : 9명의 약물 비노출 ADHD 아동군과 6명의 정상 대조군을 대상으로 I-123 IPT를 정맥주사한 후 2시간 이 경과한 상태에서 SPECT를 촬영하였으며 그 영상을 분석하여 좌, 우측의 기저 신경절 DAT 특이결합/비특이 결합 비율을 구한 후, 각 군간의 차이를 정량적으로 분석하였다. ADHD 아동의 증상과 DAT 밀도와의 연관성을 알아보기 위하여 ADHD 평가 척도(ADHD Ratin

Bone metastasis from a spinal cord astrocytoma has been reported only twice in the English medical literature. It is generally known that bone metastasis is found after the initial diagnosis with/without intervening surgery rather than being found at the time of the diagnosis of astrocytoma. The purpose of this article is to report for the first time a case of concurrent bone metastasis from a spinal cord astrocytoma at the time of diagnosing the spinal cord astrocytoma.

>연구목적 : 주의력결핍 과잉행동장애 (Attention Deficit Hyperactivity disorder ; 이하 ADHD)는 도파민계의 이상 기능으로 생기는 대표적 소아정신과 질환이다. Methylphenidate는 dopamine transporter (DAT)를 차단함으로써 ADHD 증상을 호전시키는 약물로 널리 알려져 있다. 따라서 본 연구에서는 ADHD 아동들을 대상으로 iodine-123 N-(3-iodopropen-2-yl)-2β-carbomethoxy-3β-(4-chlorophenyl) tropane ([123I]IPT) SPECT를 이용하여 methylphenidate 투여 전,후의 DAT density 양상을 비교해 보고자 한다. 방 법 : 연구대상은 7명의 ADHD 아동과 8명의 정상 대조군이었다. ADHD 아동군과 정상 대조군에게 모두 약물 비노출 상태에서 [123I]IPT 를 정맥 주사후 2시간이 경과한 상태에서 SPECT를 촬영하였다. 이후 ADHD

Metastatic struma ovarii is an extremely rare disease,and the treatment of choice has not been established. Here, we introduce the case of a 36-year-old female pregnantpatient with metastatic struma ovarii. Initial treatment was anexploratory laparotomy to remove multiple peritoneal masses. After delivery, a total thyroidectomy was done for the further131I-therapy. 131I-SPECT/CT and 18F-FDG PET/CT showedmultiple hepatic metastases and extensive peritoneal seedingnodules. Multiple 131I and retino

Objectives：The symptoms of attention-deficit/hyperactivity disorder (ADHD) can be treated with methylphenidate, a potent blocker of the dopamine transporter (DAT). The homozygosity of the 10-repeat allele at dopamine transporter gene (DAT1) seems to be associated with a poor response to methylphenidate (MPH) in children with ADHD. In present study, we investigated association between DAT density using I-123N-(3-iodopropen-2-yl)-2β-carbomethoxy-3beta-(4-chlorophenyl)tropane ([123I]IPT SPECT) and